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CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP

Kanako Nishiyama, View ORCID ProfileMasashi Maekawa  Correspondence email, View ORCID ProfileTomoya Nakagita, View ORCID ProfileJun Nakayama, Takeshi Kiyoi, Mami Chosei, Akari Murakami, Yoshiaki Kamei, Hiroyuki Takeda, View ORCID ProfileYasutsugu Takada, View ORCID ProfileShigeki Higashiyama  Correspondence email
Kanako Nishiyama
1Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University Graduate School of Medicine, Toon, Japan
2Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Japan
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Masashi Maekawa
2Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Japan
3Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Toon, Japan
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  • ORCID record for Masashi Maekawa
  • For correspondence: masashim@m.ehime-u.ac.jp
Tomoya Nakagita
4Division of Proteo-Drug-Discovery Sciences, Proteo-Science Center, Ehime University, Matsuyama, Japan
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  • ORCID record for Tomoya Nakagita
Jun Nakayama
5Division of Cellular Signaling, National Cancer Center Research Institute, Chuo-ku, Japan
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Takeshi Kiyoi
6Division of Analytical Bio-medicine, Advanced Research Support Center, Ehime University, Toon, Japan
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Mami Chosei
3Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Toon, Japan
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Akari Murakami
1Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University Graduate School of Medicine, Toon, Japan
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Yoshiaki Kamei
1Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University Graduate School of Medicine, Toon, Japan
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Hiroyuki Takeda
4Division of Proteo-Drug-Discovery Sciences, Proteo-Science Center, Ehime University, Matsuyama, Japan
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Yasutsugu Takada
1Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University Graduate School of Medicine, Toon, Japan
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  • ORCID record for Yasutsugu Takada
Shigeki Higashiyama
2Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Japan
3Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Toon, Japan
7Department of Molecular and Cellular Biology, Osaka International Cancer Institute, Chuo-ku, Osaka, Japan
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Published 29 June 2021. DOI: 10.26508/lsa.202101095
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Article Information

vol. 4 no. 9 e202101095
DOI 
https://doi.org/10.26508/lsa.202101095
PubMed 
34187934

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received April 15, 2021
  • Revision received June 17, 2021
  • Accepted June 21, 2021
  • Published online June 29, 2021.

Copyright & Usage 
© 2021 Nishiyama et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Kanako Nishiyama1,2,*,
  2. Masashi Maekawa2,3,*⇑,
  3. Tomoya Nakagita4,
  4. Jun Nakayama5,
  5. Takeshi Kiyoi6,
  6. Mami Chosei3,
  7. Akari Murakami1,
  8. Yoshiaki Kamei1,
  9. Hiroyuki Takeda4,
  10. Yasutsugu Takada1 and
  11. Shigeki Higashiyama2,3,7⇑
  1. 1Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University Graduate School of Medicine, Toon, Japan
  2. 2Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Japan
  3. 3Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Toon, Japan
  4. 4Division of Proteo-Drug-Discovery Sciences, Proteo-Science Center, Ehime University, Matsuyama, Japan
  5. 5Division of Cellular Signaling, National Cancer Center Research Institute, Chuo-ku, Japan
  6. 6Division of Analytical Bio-medicine, Advanced Research Support Center, Ehime University, Toon, Japan
  7. 7Department of Molecular and Cellular Biology, Osaka International Cancer Institute, Chuo-ku, Osaka, Japan
  1. Correspondence: masashim{at}m.ehime-u.ac.jp
  2. shigeki{at}m.ehime-u.ac.jp
  1. ↵* Kanako Nishiyama and Masashi Maekawa contributed equally to this work

View Full Text

Funding

  • JSPS KAKENHI

    19K18030
    K Nishiyama
  • Japan Foundation for Applied Enzymology, Research Grant of the Princess Takamatsu Cancer Research Fund, The Research Foundation for Pharmaceutical Sciences

    M Maekawa
  • JSPS KAKENHI

    19K18029
    A Murakami
  • SPS KAKENHI

    21H02763
    S Higashiyama
  • Takeda Science Foundation to Proteo-Science Center

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EGFR phosphatase activation by the CNKSR1/RhoB complex
Kanako Nishiyama, Masashi Maekawa, Tomoya Nakagita, Jun Nakayama, Takeshi Kiyoi, Mami Chosei, Akari Murakami, Yoshiaki Kamei, Hiroyuki Takeda, Yasutsugu Takada, Shigeki Higashiyama
Life Science Alliance Jun 2021, 4 (9) e202101095; DOI: 10.26508/lsa.202101095

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EGFR phosphatase activation by the CNKSR1/RhoB complex
Kanako Nishiyama, Masashi Maekawa, Tomoya Nakagita, Jun Nakayama, Takeshi Kiyoi, Mami Chosei, Akari Murakami, Yoshiaki Kamei, Hiroyuki Takeda, Yasutsugu Takada, Shigeki Higashiyama
Life Science Alliance Jun 2021, 4 (9) e202101095; DOI: 10.26508/lsa.202101095
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Volume 4, No. 9
September 2021
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