Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer

Kathleen M McAndrews; Fei Xiao; Antonios Chronopoulos; Valerie S LeBleu; Fernanda G Kugeratski; Raghu Kalluri

doi:10.26508/lsa.202000875

Research Article

Open Access

Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic Kras^G12D in pancreatic cancer

View ORCID ProfileKathleen M McAndrews, Fei Xiao, Antonios Chronopoulos, Valerie S LeBleu, Fernanda G Kugeratski, View ORCID ProfileRaghu Kalluri Correspondence email

Kathleen M McAndrews

1Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA

Roles: Data curation, Formal analysis, Investigation, Visualization, Writing—original draft, review, and editing

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ORCID record for Kathleen M McAndrews

Fei Xiao

1Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA

Roles: Data curation, Formal analysis, Investigation, Methodology

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Antonios Chronopoulos

1Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA

Roles: Data curation, Visualization, Writing—original draft, review, and editing

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Valerie S LeBleu

1Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA

4Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

Roles: Supervision, Investigation, Project administration

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Fernanda G Kugeratski

1Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA

Roles: Data curation, Investigation, Visualization, Writing—review and editing

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Raghu Kalluri

1Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA

2Department of Bioengineering, Rice University, Houston, TX, USA

3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA

Roles: Conceptualization, Supervision, Funding acquisition, Writing—original draft, review, and editing

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ORCID record for Raghu Kalluri
For correspondence: rkalluri@mdanderson.org

Published 19 July 2021. DOI: 10.26508/lsa.202000875

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Exosomes for CRISPR targeting of oncogenic KrasG12D mutation