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About the Cover

September 2021 | Volume 4, No. 9

Research Articles

  • CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP
    Open Access
    CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP

    Kanako Nishiyama, Masashi Maekawa, Tomoya Nakagita, Jun Nakayama, Takeshi Kiyoi, Mami Chosei, Akari Murakami, Yoshiaki Kamei, Hiroyuki Takeda, Yasutsugu Takada, Shigeki Higashiyama

    Kanako Nishiyama ... Shigeki Higashiyama

    Published 29 June 2021

    CNKSR1 functions as a scaffold protein for activation of an EGFR phosphatase, PTPRH, at the plasma membrane through the exclusive interaction with RhoB-GTP which is constitutively degraded by the CUL3/KCTD10 E3 complex.

  • Negative correlation of single-cell <em>PAX3:FOXO1</em> expression with tumorigenicity in rhabdomyosarcoma
    Open Access
    Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcoma

    Carla Regina, Ebrahem Hamed, Geoffroy Andrieux, Sina Angenendt, Michaela Schneider, Manching Ku, Marie Follo, Marco Wachtel, Eugene Ke, Ken Kikuchi, Anton G Henssen, Beat W Schäfer, Melanie Boerries, Amy J Wagers, Charles Keller, Simone Hettmer

    Carla Regina ... Simone Hettmer

    Published 29 June 2021

    Single-cell PAX3:FOXO1 expression in rhabdomyosarcoma is variable. PAX3:FOXO1 low cell states are characterized by more efficient adhesion, migration and tumor-propagating capacity.

  • UVB mutagenesis differs in <em>Nras</em>- and <em>Braf</em>-mutant mouse models of melanoma
    Open Access
    UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma

    Robert L Bowman, Rebecca C Hennessey, Tirzah J Weiss, David A Tallman, Emma R Crawford, Brandon M Murphy, Amy Webb, Souhui Zhang, Krista MD La Perle, Craig J Burd, Ross L Levine, A Hunter Shain, Christin E Burd

    Robert L Bowman ... Christin E Burd

    Published 1 July 2021

    A single, neonatal UVB exposure drives greater UV-signature production in Braf- than Nras-mutant murine melanomas.

  • The stabilized Pol31–Pol3 interface counteracts Pol32 ablation with differential effects on repair
    Open Access
    The stabilized Pol31–Pol3 interface counteracts Pol32 ablation with differential effects on repair

    Kenji Shimada, Monika Tsai-Pflugfelder, Niloofar Davoodi Vijeh Motlagh, Neda Delgoshaie, Jeannette Fuchs, Heinz Gut, Susan M Gasser

    Kenji Shimada ... Susan M Gasser

    Published 5 July 2021

    DNA pol δ is needed for lagging strand replication and DNA repair. We shed light on both distinct and common roles of the second and third subunits, Pol31 and Pol32, in S-phase linked repair pathways.

  • A serum proteome signature to predict mortality in severe COVID-19 patients
    Open Access
    A serum proteome signature to predict mortality in severe COVID-19 patients

    Franziska Völlmy, Henk van den Toorn, Riccardo Zenezini Chiozzi, Ottavio Zucchetti, Alberto Papi, Carlo Alberto Volta, Luisa Marracino, Francesco Vieceli Dalla Sega, Francesca Fortini, Vadim Demichev, Pinkus Tober-Lau, Gianluca Campo, Marco Contoli, Markus Ralser, Florian Kurth, Savino Spadaro, Paola Rizzo, Albert JR Heck

    Franziska Völlmy ... Albert JR Heck

    Published 5 July 2021

    A serum proteome panel, which includes several type-3 cystatins and inter-α-trypsin inhibitors, predicts mortality in severe COVID-19 patients very well, in three independent cohorts.

  • PNKP is required for maintaining the integrity of progenitor cell populations in adult mice
    Open Access
    PNKP is required for maintaining the integrity of progenitor cell populations in adult mice

    Wisoo Shin, Whitney Alpaugh, Laura J Hallihan, Sarthak Sinha, Emilie Crowther, Gary R Martin, Teresa Scheidl-Yee, Xiaoyan Yang, Grace Yoon, Taylor Goldsmith, Nelson D Berger, Luiz GN de Almeida, Antoine Dufour, Ina Dobrinski, Michael Weinfeld, Frank R Jirik, Jeff Biernaskie

    Wisoo Shin ... Jeff Biernaskie

    Published 5 July 2021

    Knockout of Pnkp in adult mice impairs the growth of hair follicle, spermatogonial, and neural progenitor populations.

  • Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B signaling
    Open Access
    Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B signaling

    Toshio Takahashi, Akira Shiraishi, Jun Murata, Shin Matsubara, Satsuki Nakaoka, Shinji Kirimoto, Masatake Osawa

    Toshio Takahashi ... Masatake Osawa

    Published 9 July 2021

    A signaling cascade composing M3, EphB/ephrin-B, and MEK synergizes to guide the homeostasis of intestinal epithelial cell growth and differentiation following modifications of the cholinergic intestinal niche.

  • Long noncoding RNA HOTAIR interacts with Y-Box Protein-1 (YBX1) to regulate cell proliferation
    Open Access
    Long noncoding RNA HOTAIR interacts with Y-Box Protein-1 (YBX1) to regulate cell proliferation

    Siting Li, Qian Xiong, Minghai Chen, Bing Wang, Xue Yang, Mingkun Yang, Qiang Wang, Zongqiang Cui, Feng Ge

    Siting Li ... Feng Ge

    Published 15 July 2021

    The authors determined that HOTAIR specifically bind to YBX1 and promote its nuclear translocation, and then regulating cell proliferation by stimulating the PI3K/Akt and ERK/RSK signaling pathways.

  • Distinct mechanisms mediate X chromosome dosage compensation in <em>Anopheles</em> and <em>Drosophila</em>
    Open Access
    Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila

    Claudia Isabelle Keller Valsecchi, Eric Marois, M Felicia Basilicata, Plamen Georgiev, Asifa Akhtar

    Claudia Isabelle Keller Valsecchi ... Asifa Akhtar

    Published 15 July 2021

    CRISPR knockout of msl-2 and epigenome analyses in Anopheles reveal that X chromosome dosage compensation in mosquitos and Drosophila is achieved by two different molecular mechanisms.

  • Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrity
    Open Access
    Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrity

    Bidyut K Mohanty, Joseph AQ Karam, Breege V Howley, Annamarie C Dalton, Simon Grelet, Toros Dincman, William S Streitfeld, Je-Hyun Yoon, Lata Balakrishnan, Walter J Chazin, David T Long, Philip H Howe

    Bidyut K Mohanty ... Philip H Howe

    Published 16 July 2021

    hnRNP E1 binds polycytosine tracts of DNA and monitors genome integrity.

  • Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic Kras<sup>G12D</sup> in pancreatic cancer
    Open Access
    Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer

    Kathleen M McAndrews, Fei Xiao, Antonios Chronopoulos, Valerie S LeBleu, Fernanda G Kugeratski, Raghu Kalluri

    Kathleen M McAndrews ... Raghu Kalluri

    Published 19 July 2021

    This work identifies the use of exosomes to specifically deliver CRISPR/Cas9 to target oncogenic KrasG12D mutation in pancreatic cancer as a nonviral therapeutic strategy.

  • Hepatitis B virus compartmentalization and single-cell differentiation in hepatocellular carcinoma
    Open Access
    Hepatitis B virus compartmentalization and single-cell differentiation in hepatocellular carcinoma

    Frank Jühling, Antonio Saviano, Clara Ponsolles, Laura Heydmann, Emilie Crouchet, Sarah C Durand, Houssein El Saghire, Emanuele Felli, Véronique Lindner, Patrick Pessaux, Nathalie Pochet, Catherine Schuster, Eloi R Verrier, Thomas F Baumert

    Frank Jühling ... Thomas F Baumert

    Published 21 July 2021

    Single-cell RNA-Seq unravels heterogeneity and compartmentalization of both hepatitis B virus and cancer identifying new candidate pathways for viral hepatocarcinogenesis.

  • Sequencing of a central nervous system tumor demonstrates cancer transmission in an organ transplant
    Open Access
    Sequencing of a central nervous system tumor demonstrates cancer transmission in an organ transplant

    Marie-Claude Gingras, Aniko Sabo, Maria Cardenas, Abbas Rana, Sadhna Dhingra, Qingchang Meng, Jianhong Hu, Donna M Muzny, Harshavardhan Doddapaneni, Lesette Perez, Viktoriya Korchina, Caitlin Nessner, Xiuping Liu, Hsu Chao, John Goss, Richard A Gibbs

    Marie-Claude Gingras ... Richard A Gibbs

    Published 22 July 2021

    This study uses DNA sequencing to trace a donor organ transplant–mediated cancer transmission and illustrates how precise molecular pathology profiles might reduce future risk for transplant recipients.

  • Small intestinal flora graft alters fecal flora, stool, cytokines and mood status in healthy mice
    Open Access
    Small intestinal flora graft alters fecal flora, stool, cytokines and mood status in healthy mice

    Yinyin Xie, Linyang Song, Junhua Yang, Taoqi Tao, Jing Yu, Jingrong Shi, Xiaobao Jin

    Yinyin Xie ... Xiaobao Jin

    Published 23 July 2021

    Transplantation of microbiota from small intestine, not large intestine, of healthy mice exerts obvious effects on healthy recipients, bringing a new perspective on gut flora transplantation.

  • High-dose intravenous immunoglobulins might modulate inflammation in COVID-19 patients
    Open Access
    High-dose intravenous immunoglobulins might modulate inflammation in COVID-19 patients

    María Luisa Rodríguez de la Concepción, Erola Ainsua-Enrich, Esteban Reynaga, Carlos Ávila-Nieto, Jose Ramón Santos, Silvia Roure, Lourdes Mateu, Roger Paredes, Jordi Puig, Juan Manuel Jimenez, Nuria Izquierdo-Useros, Bonaventura Clotet, María Luisa Pedro-Botet, Jorge Carrillo

    María Luisa Rodríguez de la Concepción ... Jorge Carrillo

    Published 28 July 2021

    High-dose of IVIG show immunomodulatory properties that may be useful for controlling the hyperinflammatory status observed in COVID-19 patients.

  • Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells
    Open Access
    Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells

    Yelena Sargsyan, Uta Bickmeyer, Christine S Gibhardt, Katrin Streckfuss-Bömeke, Ivan Bogeski, Sven Thoms

    Yelena Sargsyan ... Sven Thoms

    Published 30 July 2021

    Using genetically encoded Förster resonance energy transfer calcium sensors for the peroxisome, this study dissects the previously contentious peroxisome involvement in calcium handling in HeLa cells and in cardiomyocytes derived from human induced pluripotent stem cells.

Resources

  • Functional annotation of noncoding mutations in cancer
    Open Access
    Functional annotation of noncoding mutations in cancer

    Husen M Umer, Karolina Smolinska, Jan Komorowski, Claes Wadelius

    Husen M Umer ... Claes Wadelius

    Published 19 July 2021

    Recurrent regulatory mutations affecting transcription factor binding sites in 2,500 cancer samples.

  • Dynamic changes in RNA–protein interactions and RNA secondary structure in mammalian erythropoiesis
    Open Access
    Dynamic changes in RNA–protein interactions and RNA secondary structure in mammalian erythropoiesis

    Mengge Shan, Xinjun Ji, Kevin Janssen, Ian M Silverman, Jesse Humenik, Ben A Garcia, Stephen A Liebhaber, Brian D Gregory

    Mengge Shan ... Brian D Gregory

    Published 27 July 2021

    Analysis of PIP-seq data from a model of erythropoiesis reveals dynamics of RBP–RNA interaction and changes in RNA secondary structure throughout red blood cell development.

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Volume 4, No. 9
September 2021
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