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Research Articles
CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTPCNKSR1 functions as a scaffold protein for activation of an EGFR phosphatase, PTPRH, at the plasma membrane through the exclusive interaction with RhoB-GTP which is constitutively degraded by the CUL3/KCTD10 E3 complex.
Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcomaSingle-cell PAX3:FOXO1 expression in rhabdomyosarcoma is variable. PAX3:FOXO1 low cell states are characterized by more efficient adhesion, migration and tumor-propagating capacity.
UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanomaA single, neonatal UVB exposure drives greater UV-signature production in Braf- than Nras-mutant murine melanomas.
The stabilized Pol31–Pol3 interface counteracts Pol32 ablation with differential effects on repairDNA pol δ is needed for lagging strand replication and DNA repair. We shed light on both distinct and common roles of the second and third subunits, Pol31 and Pol32, in S-phase linked repair pathways.
A serum proteome signature to predict mortality in severe COVID-19 patientsA serum proteome panel, which includes several type-3 cystatins and inter-α-trypsin inhibitors, predicts mortality in severe COVID-19 patients very well, in three independent cohorts.
PNKP is required for maintaining the integrity of progenitor cell populations in adult miceKnockout of Pnkp in adult mice impairs the growth of hair follicle, spermatogonial, and neural progenitor populations.
Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B signalingA signaling cascade composing M3, EphB/ephrin-B, and MEK synergizes to guide the homeostasis of intestinal epithelial cell growth and differentiation following modifications of the cholinergic intestinal niche.
Long noncoding RNA HOTAIR interacts with Y-Box Protein-1 (YBX1) to regulate cell proliferationThe authors determined that HOTAIR specifically bind to YBX1 and promote its nuclear translocation, and then regulating cell proliferation by stimulating the PI3K/Akt and ERK/RSK signaling pathways.
Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and DrosophilaCRISPR knockout of msl-2 and epigenome analyses in Anopheles reveal that X chromosome dosage compensation in mosquitos and Drosophila is achieved by two different molecular mechanisms.
Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrityhnRNP E1 binds polycytosine tracts of DNA and monitors genome integrity.
Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancerThis work identifies the use of exosomes to specifically deliver CRISPR/Cas9 to target oncogenic KrasG12D mutation in pancreatic cancer as a nonviral therapeutic strategy.
Hepatitis B virus compartmentalization and single-cell differentiation in hepatocellular carcinomaSingle-cell RNA-Seq unravels heterogeneity and compartmentalization of both hepatitis B virus and cancer identifying new candidate pathways for viral hepatocarcinogenesis.
Sequencing of a central nervous system tumor demonstrates cancer transmission in an organ transplantThis study uses DNA sequencing to trace a donor organ transplant–mediated cancer transmission and illustrates how precise molecular pathology profiles might reduce future risk for transplant recipients.
Small intestinal flora graft alters fecal flora, stool, cytokines and mood status in healthy miceTransplantation of microbiota from small intestine, not large intestine, of healthy mice exerts obvious effects on healthy recipients, bringing a new perspective on gut flora transplantation.
High-dose intravenous immunoglobulins might modulate inflammation in COVID-19 patientsHigh-dose of IVIG show immunomodulatory properties that may be useful for controlling the hyperinflammatory status observed in COVID-19 patients.
Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cellsUsing genetically encoded Förster resonance energy transfer calcium sensors for the peroxisome, this study dissects the previously contentious peroxisome involvement in calcium handling in HeLa cells and in cardiomyocytes derived from human induced pluripotent stem cells.
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Functional annotation of noncoding mutations in cancerRecurrent regulatory mutations affecting transcription factor binding sites in 2,500 cancer samples.
Dynamic changes in RNA–protein interactions and RNA secondary structure in mammalian erythropoiesisAnalysis of PIP-seq data from a model of erythropoiesis reveals dynamics of RBP–RNA interaction and changes in RNA secondary structure throughout red blood cell development.
