Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations

Urška Rovšnik; Yuxuan Zhuang; Björn O Forsberg; Marta Carroni; Linnea Yvonnesdotter; Rebecca J Howard; Erik Lindahl

doi:10.26508/lsa.202101011

Research Article

Open Access

Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations

Urška Rovšnik, Yuxuan Zhuang, Björn O Forsberg, Marta Carroni, Linnea Yvonnesdotter, View ORCID ProfileRebecca J Howard, View ORCID ProfileErik Lindahl Correspondence email

Urška Rovšnik

1Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden

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Yuxuan Zhuang

1Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden

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Björn O Forsberg

1Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden

2Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK

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Marta Carroni

1Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden

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Linnea Yvonnesdotter

1Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden

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Rebecca J Howard

1Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden

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ORCID record for Rebecca J Howard

Erik Lindahl

1Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden

3Department of Applied Physics, Science for Life Laboratory, Kungliga Tekniska Högskolan Royal Institute of Technology, Solna, Sweden

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ORCID record for Erik Lindahl
For correspondence: erik.lindahl@scilifelab.se

Published 1 July 2021. DOI: 10.26508/lsa.202101011

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Cryo-EM and simulations of closed GLIC