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Table of Contents

August 2021 | Volume 4, No. 8

Research Articles

  • IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection
    Open Access
    IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection

    Alistair L Chenery, Silvia Rosini, James E Parkinson, Jesuthas Ajendra, Jeremy A Herrera, Craig Lawless, Brian HK Chan, P’ng Loke, Andrew S MacDonald, Karl E Kadler, Tara E Sutherland, Judith E Allen

    Alistair L Chenery ... Judith E Allen

    Published 14 June 2021

    IL-13 is tissue protective during acute lung injury caused by nematode migration and specifically regulates type 2 epithelial cell effector functions.

  • Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in <em>Drosophila</em>
    Open Access
    Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila

    Himani Pathak, Jishy Varghese

    Himani Pathak ... Jishy Varghese

    Published 17 June 2021

    Edem1, an endoplasmic reticulum-resident protein, acts in the fat body to regulate insulin signalling and metabolic status in Drosophila, which aids in survival against nutrient deprivation.

  • HCV poly U/UC sequence–induced inflammation leads to metabolic disorders in vulvar lichen sclerosis
    Open Access
    HCV poly U/UC sequence–induced inflammation leads to metabolic disorders in vulvar lichen sclerosis

    Qing Cong, Xiao Guo, Shengwei Zhang, Jinhui Wang, Yi Zhu, Lili Wang, Guangxing Lu, Yufeng Zhang, Wei Fu, Liying Zhou, Shuaikang Wang, Cenxi Liu, Jia Song, Chaoyong Yang, Chi Luo, Ting Ni, Long Sui, He Huang, Jin Li

    Qing Cong ... Jin Li

    Published 18 June 2021

    Multi-omics analysis reveals the elevation of HCV poly U/UC sequences, which induces abnormal inflammation and related metabolic disorder in vulvar lichen sclerosis.

  • A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolism
    Open Access
    A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolism

    Angel Loza-Valdes, Alexander E Mayer, Toufic Kassouf, Jonathan Trujillo-Viera, Werner Schmitz, Filip Dziaczkowski, Michael Leitges, Andreas Schlosser, Grzegorz Sumara

    Angel Loza-Valdes ... Grzegorz Sumara

    Published 18 June 2021

    Protein kinase D3 (PKD3) regulates hepatic metabolism in a PKA-dependent manner and reveals many other putative PKD3 targets in the liver.

  • Profiling chromatin accessibility responses in human neutrophils with sensitive pathogen detection
    Open Access
    Profiling chromatin accessibility responses in human neutrophils with sensitive pathogen detection

    Nikhil Ram-Mohan, Simone A Thair, Ulrike M Litzenburger, Steven Cogill, Nadya Andini, Xi Yang, Howard Y Chang, Samuel Yang

    Nikhil Ram-Mohan ... Samuel Yang

    Published 18 June 2021

    ATAC-seq reveals unique neutrophil chromatin architecture changes in response to different stimuli before transcriptional activation, possibly regulating downstream gene expression.

  • Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress
    Open Access
    Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress

    Moona Huttunen, Jerzy Samolej, Robert J Evans, Artur Yakimovich, Ian J White, Janos Kriston-Vizi, Juan Martin-Serrano, Wesley I Sundquist, Eva-Maria Frickel, Jason Mercer

    Moona Huttunen ... Jason Mercer

    Published 18 June 2021

    Poxvirus extracellular virions are critical for virus virulence. This study shows that multivesicular bodies serve as a major cellular source of membrane for their formation and spread.

  • Hierarchical dinucleotide distribution in genome along evolution and its effect on chromatin packing
    Open Access
    Hierarchical dinucleotide distribution in genome along evolution and its effect on chromatin packing

    Zhicheng Cai, Yueying He, Sirui Liu, Yue Xue, Hui Quan, Ling Zhang, Yi Qin Gao

    Zhicheng Cai ... Yi Qin Gao

    Published 24 June 2021

    It describes how hierarchical CpG distribution on the genomes of species change in the evolution and the correlation with the chromatin structure.

  • Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19
    Open Access
    Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19

    Lucas Cardoso Lazari, Fabio De Rose Ghilardi, Livia Rosa-Fernandes, Diego M Assis, José Carlos Nicolau, Veronica Feijoli Santiago, Talia Falcão Dalçóquio, Claudia B Angeli, Adriadne Justi Bertolin, Claudio RF Marinho, Carsten Wrenger, Edison Luiz Durigon, Rinaldo Focaccia Siciliano, Giuseppe Palmisano

    Lucas Cardoso Lazari ... Giuseppe Palmisano

    Published 24 June 2021

    High mortality rate in SARS-CoV-2–infected individuals requires accurate markers for predicting COVID-19 severity. MALDI-TOF analysis revealed differential plasma levels of SAA1 and SAA2 associated with higher risk of hospitalization and can be used to improve COVID-19 monitoring and therapy.

  • Asymmetrical deposition and modification of histone H3 variants are essential for zygote development
    Open Access
    Asymmetrical deposition and modification of histone H3 variants are essential for zygote development

    Machika Kawamura, Satoshi Funaya, Kenta Sugie, Masataka G Suzuki, Fugaku Aoki

    Machika Kawamura ... Fugaku Aoki

    Published 24 June 2021

    A low level of H3.1/2 deposition in the perinucleolar regions of male pronuclei in zygotes prevents accumulation of H3.1/2K27me3 modification which has detrimental effect on DNA replication.

  • Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup
    Open Access
    Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup

    Francesc X Guix, Ana Marrero Capitán, Álvaro Casadomé-Perales, Irene Palomares-Pérez, Inés López del Castillo, Verónica Miguel, Leigh Goedeke, Mauricio G Martín, Santiago Lamas, Héctor Peinado, Carlos Fernández-Hernando, Carlos G Dotti

    Francesc X Guix ... Carlos G Dotti

    Published 28 June 2021

    The present study unveils the molecular mechanism through which neurons in vitro compensate age-associated proteostasis defects by increasing exosome release.

  • Macrophages-induced IL-18–mediated eosinophilia promotes characteristics of pancreatic malignancy
    Open Access
    Macrophages-induced IL-18–mediated eosinophilia promotes characteristics of pancreatic malignancy

    Hemanth Kumar Kandikattu, Murli Manohar, Alok Kumar Verma, Sandeep Kumar, Chandra Sekhar Yadavalli, Sathisha Upparahalli Venkateshaiah, Anil Mishra

    Hemanth Kumar Kandikattu ... Anil Mishra

    Published 28 June 2021

    The current study presents first CP murine model that show IL-18–induced eosinophil inflammation-mediated induction of oncogenic proteins and several pathological malignant characteristics.

  • TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration
    Open Access
    TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration

    Yanfen Li, Christian Schön, Cheng-Chang Chen, Zhuo Yang, Raffael Liegl, Elisa Murenu, Benedikt Schworm, Norbert Klugbauer, Christian Grimm, Christian Wahl-Schott, Stylianos Michalakis, Martin Biel

    Yanfen Li ... Martin Biel

    Published 28 June 2021

    This study identifies the endolysosomal two-pore channel TPC2 as a potential novel drug target for age-related macular degeneration (AMD). Inhibition of TPC2 reduces two key clinical hallmarks of the AMD, retinal inflammation and formation of leaky choroi.

  • Stepwise transmigration of T- and B cells through a perivascular channel in high endothelial venules
    Open Access
    Stepwise transmigration of T- and B cells through a perivascular channel in high endothelial venules

    Kibaek Choe, Jieun Moon, Soo Yun Lee, Eunjoo Song, Ju Hee Back, Joo-Hye Song, Young-Min Hyun, Kenji Uchimura, Pilhan Kim

    Kibaek Choe ... Pilhan Kim

    Published 29 June 2021

    Intravital imaging reveals stepwise transmigration cascade of T- and B cells across endothelial cells and fibroblastic reticular cells in lymph node high endothelial venules via hot spots.

  • Deletion of a pseudogene within a fragile site triggers the oncogenic expression of the mitotic CCSER1 gene
    Open Access
    Deletion of a pseudogene within a fragile site triggers the oncogenic expression of the mitotic CCSER1 gene

    Benedetta M Santoliquido, Michela Frenquelli, Claudia Contadini, Stefano Bestetti, Marco Gaviraghi, Elisa Barbieri, Anna De Antoni, Luca Albarello, Angelo Amabile, Alessandro Gardini, Angelo Lombardo, Claudio Doglioni, Paolo Provero, Silvia Soddu, Davide Cittaro, Giovanni Tonon

    Benedetta M Santoliquido ... Giovanni Tonon

    Published 29 June 2021

    Frequent deletions impacting the FRA4F fragile site leads to the oncogenic overexpression of the corresponding CCSER1 gene, through the deletion of the TMSB4XP8 pseudogene. The ensuing CCSER1 overexpression elicits mitotic instability, targetable with aurora kinase inhibitors.

  • Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations
    Open Access
    Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations

    Urška Rovšnik, Yuxuan Zhuang, Björn O Forsberg, Marta Carroni, Linnea Yvonnesdotter, Rebecca J Howard, Erik Lindahl

    Urška Rovšnik ... Erik Lindahl

    Published 1 July 2021

    Cryo-EM structures and molecular simulations of a pentameric ligand-gated ion channel, GLIC, in resting and activating conditions implicate protonation sites and altered dynamics in sequential gating.

  • Axon terminals control endolysosome diffusion to support synaptic remodelling
    Open Access
    Axon terminals control endolysosome diffusion to support synaptic remodelling

    Beatrice Terni, Artur Llobet

    Beatrice Terni ... Artur Llobet

    Published 5 July 2021

    Endolysosomes present in the presynaptic terminal move by diffusion constrained by F-actin and increase their mobility during the remodelling of synaptic connectivity to support a local degradative activity.

Correction

  • Open Access
    Correction: An essential role for α4A-tubulin in platelet biogenesis

    Catherine Strassel, Maria M Magiera, Arnaud Dupuis, Morgane Batzenschlager, Agnès Hovasse, Irina Pleines, Paul Guéguen, Anita Eckly, Sylvie Moog, Léa Mallo, Quentin Kimmerlin, Stéphane Chappaz, Jean-Marc Strub, Natarajan Kathiresan, Henri de la Salle, Alain Van Dorsselaer, Claude Ferec, Jean-Yves Py, Christian Gachet, Christine Schaeffer-Reiss, Benjamin T Kile, Carsten Janke, François Lanza

    Catherine Strassel ... François Lanza

    Published 21 June 2021
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Volume 4, No. 8
August 2021
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