Table of Contents
Research Articles
IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infectionIL-13 is tissue protective during acute lung injury caused by nematode migration and specifically regulates type 2 epithelial cell effector functions.
Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in DrosophilaEdem1, an endoplasmic reticulum-resident protein, acts in the fat body to regulate insulin signalling and metabolic status in Drosophila, which aids in survival against nutrient deprivation.
HCV poly U/UC sequence–induced inflammation leads to metabolic disorders in vulvar lichen sclerosisMulti-omics analysis reveals the elevation of HCV poly U/UC sequences, which induces abnormal inflammation and related metabolic disorder in vulvar lichen sclerosis.
A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolismProtein kinase D3 (PKD3) regulates hepatic metabolism in a PKA-dependent manner and reveals many other putative PKD3 targets in the liver.
Profiling chromatin accessibility responses in human neutrophils with sensitive pathogen detectionATAC-seq reveals unique neutrophil chromatin architecture changes in response to different stimuli before transcriptional activation, possibly regulating downstream gene expression.
Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egressPoxvirus extracellular virions are critical for virus virulence. This study shows that multivesicular bodies serve as a major cellular source of membrane for their formation and spread.
Hierarchical dinucleotide distribution in genome along evolution and its effect on chromatin packingIt describes how hierarchical CpG distribution on the genomes of species change in the evolution and the correlation with the chromatin structure.
Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19High mortality rate in SARS-CoV-2–infected individuals requires accurate markers for predicting COVID-19 severity. MALDI-TOF analysis revealed differential plasma levels of SAA1 and SAA2 associated with higher risk of hospitalization and can be used to improve COVID-19 monitoring and therapy.
Asymmetrical deposition and modification of histone H3 variants are essential for zygote developmentA low level of H3.1/2 deposition in the perinucleolar regions of male pronuclei in zygotes prevents accumulation of H3.1/2K27me3 modification which has detrimental effect on DNA replication.
Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildupThe present study unveils the molecular mechanism through which neurons in vitro compensate age-associated proteostasis defects by increasing exosome release.
Macrophages-induced IL-18–mediated eosinophilia promotes characteristics of pancreatic malignancyThe current study presents first CP murine model that show IL-18–induced eosinophil inflammation-mediated induction of oncogenic proteins and several pathological malignant characteristics.
TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degenerationThis study identifies the endolysosomal two-pore channel TPC2 as a potential novel drug target for age-related macular degeneration (AMD). Inhibition of TPC2 reduces two key clinical hallmarks of the AMD, retinal inflammation and formation of leaky choroi.
Stepwise transmigration of T- and B cells through a perivascular channel in high endothelial venulesIntravital imaging reveals stepwise transmigration cascade of T- and B cells across endothelial cells and fibroblastic reticular cells in lymph node high endothelial venules via hot spots.
Deletion of a pseudogene within a fragile site triggers the oncogenic expression of the mitotic CCSER1 geneFrequent deletions impacting the FRA4F fragile site leads to the oncogenic overexpression of the corresponding CCSER1 gene, through the deletion of the TMSB4XP8 pseudogene. The ensuing CCSER1 overexpression elicits mitotic instability, targetable with aurora kinase inhibitors.
Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulationsCryo-EM structures and molecular simulations of a pentameric ligand-gated ion channel, GLIC, in resting and activating conditions implicate protonation sites and altered dynamics in sequential gating.
Axon terminals control endolysosome diffusion to support synaptic remodellingEndolysosomes present in the presynaptic terminal move by diffusion constrained by F-actin and increase their mobility during the remodelling of synaptic connectivity to support a local degradative activity.
