Research Article
Open Access
DNA damage in embryonic neural stem cell determines FTLDs’ fate via early-stage neuronal necrosis
Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, View ORCID ProfileChristian JF Bertens, Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hiroyasu Akatsu, Naoki Atsuta, Masahisa Katsuno, View ORCID ProfileKatsutoshi Furukawa, Aiko Ishiki, Masaaki Waragai, View ORCID ProfileGaku Ohtomo, View ORCID ProfileAtsushi Iwata, Takanori Yokota, Haruhisa Inoue, Hiroyuki Arai, Gen Sobue, Masaki Sone, Kyota Fujita, View ORCID ProfileHitoshi Okazawa Correspondence email
Hidenori Homma
1Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Hikari Tanaka
1Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Meihua Jin
1Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Xiaocen Jin
1Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Yong Huang
1Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Yuki Yoshioka
1Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Christian JF Bertens
1Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
2Department of Biomolecular Science, Faculty of Science, Toho University, Chiba, Japan
3School for Mental Health and Neuroscience (MHeNs), University Eye Clinic Maastricht, Maastricht University, Maastricht, The Netherlands
Kohei Tsumaki
2Department of Biomolecular Science, Faculty of Science, Toho University, Chiba, Japan
Kanoh Kondo
1Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Hiroki Shiwaku
1Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
4Department of Psychiatry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
Kazuhiko Tagawa
1Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Hiroyasu Akatsu
5Department of Community-Based Medical Education, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Naoki Atsuta
6Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Masahisa Katsuno
6Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Katsutoshi Furukawa
7Division of Community Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan
Aiko Ishiki
8Department of Geriatrics and Gerontology, Division of Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
Masaaki Waragai
9Department of Neurology, Higashi Matsudo Municipal Hospital, Chiba, Japan
Gaku Ohtomo
10Department of Neurology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan
Atsushi Iwata
10Department of Neurology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan
Takanori Yokota
11Department of Neurology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
Haruhisa Inoue
12Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan
13Drug-Discovery Cellular Basis Development Team, RIKEN BioResource Center, Kyoto, Japan
Hiroyuki Arai
8Department of Geriatrics and Gerontology, Division of Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
Gen Sobue
6Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Masaki Sone
1Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
2Department of Biomolecular Science, Faculty of Science, Toho University, Chiba, Japan
Kyota Fujita
1Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Hitoshi Okazawa
1Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
14Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, Japan
Published 15 June 2021. DOI: 10.26508/lsa.202101022
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Developmental DNA damage stress contributes to FTLD
Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, Christian JF Bertens, Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hiroyasu Akatsu, Naoki Atsuta, Masahisa Katsuno, Katsutoshi Furukawa, Aiko Ishiki, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Takanori Yokota, Haruhisa Inoue, Hiroyuki Arai, Gen Sobue, Masaki Sone, Kyota Fujita, Hitoshi Okazawa
Life Science Alliance Jun 2021, 4 (7) e202101022; DOI: 10.26508/lsa.202101022
Developmental DNA damage stress contributes to FTLD
Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, Christian JF Bertens, Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hiroyasu Akatsu, Naoki Atsuta, Masahisa Katsuno, Katsutoshi Furukawa, Aiko Ishiki, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Takanori Yokota, Haruhisa Inoue, Hiroyuki Arai, Gen Sobue, Masaki Sone, Kyota Fujita, Hitoshi Okazawa
Life Science Alliance Jun 2021, 4 (7) e202101022; DOI: 10.26508/lsa.202101022
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Volume 4, No. 7
July 2021
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