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Table of Contents

July 2021 | Volume 4, No. 7

Research Articles

  • Urinary prostaglandin E2 as a biomarker for recurrent UTI in postmenopausal women
    Open Access
    Urinary prostaglandin E2 as a biomarker for recurrent UTI in postmenopausal women

    Tahmineh Ebrahimzadeh, Amy Kuprasertkul, Michael L Neugent, Kevin C Lutz, Jorge L Fuentes, Jashkaran Gadhvi, Fatima Khan, Cong Zhang, Belle M Sharon, Kim Orth, Qiwei Li, Philippe E Zimmern, Nicole J De Nisco

    Tahmineh Ebrahimzadeh ... Nicole J De Nisco

    Published 6 May 2021

    This work uses controlled human cohorts to investigate urinary prostaglandin E2, the product of cyclooxygenase-2, as both a diagnostic and prognostic biomarker of recurrent UTI postmenopausal women.

  • The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targets
    Open Access
    The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targets

    Ivan V Litvinov, Pingxing Xie, Scott Gunn, Denis Sasseville, Philippe Lefrançois

    Ivan V Litvinov ... Philippe Lefrançois

    Published 10 May 2021

    Basal cell carcinoma (BCC) is the most common skin cancer and human malignancy. By analyzing BCC RNA sequencing data according to clinically important features, we identified novel differentially regulated genes and new targetable pathways. Several biomarkers were validated in patient-derived BCC samples.

  • Gametic specialization of centromeric histone paralogs in <em>Drosophila virilis</em>
    Open Access
    Gametic specialization of centromeric histone paralogs in Drosophila virilis

    Lisa E Kursel, Hannah McConnell, Aida Flor A de la Cruz, Harmit S Malik

    Lisa E Kursel ... Harmit S Malik

    Published 13 May 2021

    Somatic and germline centromeric functions could differ because of different chromatin environments in male and female gametes versus somatic cells. We show that two different centromeric histone paralogs are alternately retained in male versus female gametes in many Drosophila species.

  • Non-microtubule tubulin-based backbone and subordinate components of postsynaptic density lattices
    Open Access
    Non-microtubule tubulin-based backbone and subordinate components of postsynaptic density lattices

    Tatsuo Suzuki, Nobuo Terada, Shigeki Higashiyama, Kiyokazu Kametani, Yoshinori Shirai, Mamoru Honda, Tsutomu Kai, Weidong Li, Katsuhiko Tabuchi

    Tatsuo Suzuki ... Katsuhiko Tabuchi

    Published 18 May 2021

    This study proposes a postsynaptic density (PSD) lattice model comprising a non-microtubule tubulin-based backbone structure and its associated proteins, including various PSD scaffold/adaptor proteins and other PSD proteins.

  • Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction
    Open Access
    Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction

    Sergej Franz, Fabian Pott, Thomas Zillinger, Christiane Schüler, Sandra Dapa, Carlo Fischer, Vânia Passos, Saskia Stenzel, Fangfang Chen, Katinka Döhner, Gunther Hartmann, Beate Sodeik, Frank Pessler, Graham Simmons, Jan Felix Drexler, Christine Goffinet

    Sergej Franz ... Christine Goffinet

    Published 2 June 2021

    Endogenous and heterologpusly expressed human IFITM3 restricts early and late replication steps of chikungunya and Mayaro virus infection and is downregulated at the protein level in infected cells.

  • Specific N-cadherin–dependent pathways drive human breast cancer dormancy in bone marrow
    Open Access
    Specific N-cadherin–dependent pathways drive human breast cancer dormancy in bone marrow

    Garima Sinha, Alejandra I Ferrer, Seda Ayer, Markos H El-Far, Sri Harika Pamarthi, Yahaira Naaldijk, Pradeep Barak, Oleta A Sandiford, Bernadette M Bibber, Ghassan Yehia, Steven J Greco, Jie-Gen Jiang, Margarette Bryan, Rakesh Kumar, Nicholas M Ponzio, Jean-Pierre Etchegaray, Pranela Rameshwar

    Garima Sinha ... Pranela Rameshwar

    Published 2 June 2021

    CDH2 is required for connexin 43 (Cx43)–mediated gap junction intercellular communication between breast cancer cells and bone marrow niche cells to achieve dormancy and chemoresistance.

  • Cell-autonomous <em>Toxoplasma</em> killing program requires Irgm2 but not its microbe vacuolar localization
    Open Access
    Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization

    Ariel Pradipta, Miwa Sasai, Kou Motani, Ji Su Ma, Youngae Lee, Hidetaka Kosako, Masahiro Yamamoto

    Ariel Pradipta ... Masahiro Yamamoto

    Published 2 June 2021

    Irgm2 controls Toxoplasma killing via selective recruitment of Gbp1 and Irgb6 to Toxoplasma parasitophorous vacuoles, whereas its vacuolar localization is dispensable for parasite killing.

  • A role for condensin in mediating transcriptional adaptation to environmental stimuli
    Open Access
    A role for condensin in mediating transcriptional adaptation to environmental stimuli

    Lucy Lancaster, Harshil Patel, Gavin Kelly, Frank Uhlmann

    Lucy Lancaster ... Frank Uhlmann

    Published 3 June 2021

    Fast conditional depletion of the chromosomal condensin complex from budding yeast cells reveals roles in transcriptional regulation, especially during the establishment of new gene expression patterns.

  • Multifaceted regulation of hepatic lipid metabolism by YY1
    Open Access
    Multifaceted regulation of hepatic lipid metabolism by YY1

    Gang Pan, Klev Diamanti, Marco Cavalli, Ariadna Lara Gutiérrez, Jan Komorowski, Claes Wadelius

    Gang Pan ... Claes Wadelius

    Published 7 June 2021

    This study shows that YY1 regulates hepatic lipid metabolism by directly or indirectly regulating the expression of several key upstream transcription factors and their coactivators.

  • A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses
    Open Access
    A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses

    Huan Du, Man Ying Wong, Tingting Zhang, Mariela Nunez Santos, Charlene Hsu, Junke Zhang, Haiyuan Yu, Wenjie Luo, Fenghua Hu

    Huan Du ... Fenghua Hu

    Published 8 June 2021

    Progranulin deficiency leads to decreased levels of human APP and Aβ in a sex- and age-dependent manner and enhanced inflammatory and lysosomal responses in the plaque-associated microglia.

  • Viperin interacts with PEX19 to mediate peroxisomal augmentation of the innate antiviral response
    Open Access
    Viperin interacts with PEX19 to mediate peroxisomal augmentation of the innate antiviral response

    Onruedee Khantisitthiporn, Byron Shue, Nicholas S Eyre, Colt W Nash, Lynne Turnbull, Cynthia B Whitchurch, Kylie H Van der Hoek, Karla J Helbig, Michael R Beard

    Onruedee Khantisitthiporn ... Michael R Beard

    Published 9 June 2021

    This work highlights the multifunctional role of the ISG viperin and its interaction with the peroxisomal protein Pex19 to modulate peroxisomal-dependent innate signaling that ultimately restricts viral infection.

  • iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hosts
    Open Access
    iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hosts

    Nicholas J Hess, Nikhila S Bharadwaj, Elizabeth A Bobeck, Courtney E McDougal, Shidong Ma, John-Demian Sauer, Amy W Hudson, Jenny E Gumperz

    Nicholas J Hess ... Jenny E Gumperz

    Published 10 June 2021

    Immunotherapeutic iNKT cells interact with monocytes and T cells in human umbilical cord blood grafts to simultaneously limit inflammation while promoting hematopoietic activity.

  • WBP2 inhibits microRNA biogenesis via interaction with the microprocessor complex
    Open Access
    WBP2 inhibits microRNA biogenesis via interaction with the microprocessor complex

    Hossein Tabatabaeian, Shen Kiat Lim, Tinghine Chu, Sock Hong Seah, Yoon Pin Lim

    Hossein Tabatabaeian ... Yoon Pin Lim

    Published 11 June 2021

    WBP2 protein blocks the microRNA biogenesis via physical interactions with the microprocessor complex, and reverts the tumor-suppressive role of DGCR8.

  • Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo
    Open Access
    Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo

    Karen N McFarland, Carolina Ceballos, Awilda Rosario, Thomas Ladd, Brenda Moore, Griffin Golde, Xue Wang, Mariet Allen, Nilüfer Ertekin-Taner, Cory C Funk, Max Robinson, Priyanka Baloni, Noa Rappaport, Paramita Chakrabarty, Todd E Golde

    Karen N McFarland ... Todd E Golde

    Published 14 June 2021

    Exogenous amyloid beta peptides cause distinct transcriptomic responses in microglia cultures that are not fully replicated in an amyloid mouse model or identified microglial subpopulations in vivo.

  • DNA damage in embryonic neural stem cell determines FTLDs’ fate via early-stage neuronal necrosis
    Open Access
    DNA damage in embryonic neural stem cell determines FTLDs’ fate via early-stage neuronal necrosis

    Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, Christian JF Bertens, Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hiroyasu Akatsu, Naoki Atsuta, Masahisa Katsuno, Katsutoshi Furukawa, Aiko Ishiki, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Takanori Yokota, Haruhisa Inoue, Hiroyuki Arai, Gen Sobue, Masaki Sone, Kyota Fujita, Hitoshi Okazawa

    Hidenori Homma ... Hitoshi Okazawa

    Published 15 June 2021

    DNA damage due to impairment of DNA damage repair functions in NSCs is carried over to neurons and triggers early-stage YAP-dependent neuronal necrosis (TRIAD) amplifying a chain of necrosis in FTLDs.

  • Dissection-independent production of <em>Plasmodium</em> sporozoites from whole mosquitoes
    Open Access
    Dissection-independent production of Plasmodium sporozoites from whole mosquitoes

    Joshua Blight, Katarzyna A Sala, Erwan Atcheson, Holger Kramer, Aadil El-Turabi, Eliana Real, Farah A Dahalan, Paulo Bettencourt, Emma Dickinson-Craig, Eduardo Alves, Ahmed M Salman, Chris J Janse, Frances M Ashcroft, Adrian VS Hill, Arturo Reyes-Sandoval, Andrew M Blagborough, Jake Baum

    Joshua Blight ... Jake Baum

    Published 16 June 2021

    Overcoming limitations of traditional dissection-dependent methods for malarial sporozoite isolation from mosquitoes, a new dissection-free method is presented that yields pure, infective sporozoites.

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Volume 4, No. 7
July 2021
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