Table of Contents
Research Articles
Urinary prostaglandin E2 as a biomarker for recurrent UTI in postmenopausal womenThis work uses controlled human cohorts to investigate urinary prostaglandin E2, the product of cyclooxygenase-2, as both a diagnostic and prognostic biomarker of recurrent UTI postmenopausal women.
The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targetsBasal cell carcinoma (BCC) is the most common skin cancer and human malignancy. By analyzing BCC RNA sequencing data according to clinically important features, we identified novel differentially regulated genes and new targetable pathways. Several biomarkers were validated in patient-derived BCC samples.
Gametic specialization of centromeric histone paralogs in Drosophila virilisSomatic and germline centromeric functions could differ because of different chromatin environments in male and female gametes versus somatic cells. We show that two different centromeric histone paralogs are alternately retained in male versus female gametes in many Drosophila species.
Non-microtubule tubulin-based backbone and subordinate components of postsynaptic density latticesThis study proposes a postsynaptic density (PSD) lattice model comprising a non-microtubule tubulin-based backbone structure and its associated proteins, including various PSD scaffold/adaptor proteins and other PSD proteins.
Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteractionEndogenous and heterologpusly expressed human IFITM3 restricts early and late replication steps of chikungunya and Mayaro virus infection and is downregulated at the protein level in infected cells.
Specific N-cadherin–dependent pathways drive human breast cancer dormancy in bone marrowCDH2 is required for connexin 43 (Cx43)–mediated gap junction intercellular communication between breast cancer cells and bone marrow niche cells to achieve dormancy and chemoresistance.
Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localizationIrgm2 controls Toxoplasma killing via selective recruitment of Gbp1 and Irgb6 to Toxoplasma parasitophorous vacuoles, whereas its vacuolar localization is dispensable for parasite killing.
A role for condensin in mediating transcriptional adaptation to environmental stimuliFast conditional depletion of the chromosomal condensin complex from budding yeast cells reveals roles in transcriptional regulation, especially during the establishment of new gene expression patterns.
Multifaceted regulation of hepatic lipid metabolism by YY1This study shows that YY1 regulates hepatic lipid metabolism by directly or indirectly regulating the expression of several key upstream transcription factors and their coactivators.
A multifaceted role of progranulin in regulating amyloid-beta dynamics and responsesProgranulin deficiency leads to decreased levels of human APP and Aβ in a sex- and age-dependent manner and enhanced inflammatory and lysosomal responses in the plaque-associated microglia.
Viperin interacts with PEX19 to mediate peroxisomal augmentation of the innate antiviral responseThis work highlights the multifunctional role of the ISG viperin and its interaction with the peroxisomal protein Pex19 to modulate peroxisomal-dependent innate signaling that ultimately restricts viral infection.
iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hostsImmunotherapeutic iNKT cells interact with monocytes and T cells in human umbilical cord blood grafts to simultaneously limit inflammation while promoting hematopoietic activity.
WBP2 inhibits microRNA biogenesis via interaction with the microprocessor complexWBP2 protein blocks the microRNA biogenesis via physical interactions with the microprocessor complex, and reverts the tumor-suppressive role of DGCR8.
Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivoExogenous amyloid beta peptides cause distinct transcriptomic responses in microglia cultures that are not fully replicated in an amyloid mouse model or identified microglial subpopulations in vivo.
DNA damage in embryonic neural stem cell determines FTLDs’ fate via early-stage neuronal necrosisDNA damage due to impairment of DNA damage repair functions in NSCs is carried over to neurons and triggers early-stage YAP-dependent neuronal necrosis (TRIAD) amplifying a chain of necrosis in FTLDs.
Dissection-independent production of Plasmodium sporozoites from whole mosquitoesOvercoming limitations of traditional dissection-dependent methods for malarial sporozoite isolation from mosquitoes, a new dissection-free method is presented that yields pure, infective sporozoites.
