Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages

Samantha B Kemp; Nina G Steele; Eileen S Carpenter; Katelyn L Donahue; Grace G Bushnell; Aaron H Morris; Stephanie The; Sophia M Orbach; Veerin R Sirihorachai; Zeribe C Nwosu; Carlos Espinoza; Fatima Lima; Kristee Brown; Alexander A Girgis; Valerie Gunchick; Yaqing Zhang; Costas A Lyssiotis; Timothy L Frankel; Filip Bednar; Arvind Rao; Vaibhav Sahai; Lonnie D Shea; Howard C Crawford; Marina Pasca di Magliano

doi:10.26508/lsa.202000935

Research Article

Open Access

Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages

Samantha B Kemp, Nina G Steele, Eileen S Carpenter, Katelyn L Donahue, Grace G Bushnell, Aaron H Morris, Stephanie The, Sophia M Orbach, Veerin R Sirihorachai, Zeribe C Nwosu, Carlos Espinoza, Fatima Lima, Kristee Brown, View ORCID ProfileAlexander A Girgis, Valerie Gunchick, Yaqing Zhang, View ORCID ProfileCostas A Lyssiotis, Timothy L Frankel, View ORCID ProfileFilip Bednar, Arvind Rao, View ORCID ProfileVaibhav Sahai, Lonnie D Shea, View ORCID ProfileHoward C Crawford Correspondence email, View ORCID ProfileMarina Pasca di Magliano Correspondence email

Samantha B Kemp

1Departments of Molecular and Cellular Pathology, University of Michigan, Ann Arbor, MI, USA

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Nina G Steele

2Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA

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Eileen S Carpenter

3Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA

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Katelyn L Donahue

4Cancer Biology, University of Michigan, Ann Arbor, MI, USA

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Grace G Bushnell

5Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA

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Aaron H Morris

5Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA

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Stephanie The

6Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA

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Sophia M Orbach

5Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA

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Veerin R Sirihorachai

4Cancer Biology, University of Michigan, Ann Arbor, MI, USA

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Zeribe C Nwosu

7Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA

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Carlos Espinoza

8Surgery, University of Michigan, Ann Arbor, MI, USA

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Fatima Lima

8Surgery, University of Michigan, Ann Arbor, MI, USA

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Kristee Brown

8Surgery, University of Michigan, Ann Arbor, MI, USA

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Alexander A Girgis

8Surgery, University of Michigan, Ann Arbor, MI, USA

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ORCID record for Alexander A Girgis

Valerie Gunchick

9Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA

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Yaqing Zhang

8Surgery, University of Michigan, Ann Arbor, MI, USA

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Costas A Lyssiotis

7Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA

12Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA

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ORCID record for Costas A Lyssiotis

Timothy L Frankel

8Surgery, University of Michigan, Ann Arbor, MI, USA

12Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA

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Filip Bednar

8Surgery, University of Michigan, Ann Arbor, MI, USA

12Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA

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ORCID record for Filip Bednar

Arvind Rao

5Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA

6Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA

10Radiation Oncology, University of Michigan, Ann Arbor, MI, USA

11Biostatistics, University of Michigan, Ann Arbor, MI, USA

12Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA

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Vaibhav Sahai

9Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA

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Lonnie D Shea

5Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA

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Howard C Crawford

4Cancer Biology, University of Michigan, Ann Arbor, MI, USA

7Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA

12Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA

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ORCID record for Howard C Crawford
For correspondence: hcrawfo1@hfhs.org

Marina Pasca di Magliano

2Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA

4Cancer Biology, University of Michigan, Ann Arbor, MI, USA

8Surgery, University of Michigan, Ann Arbor, MI, USA

12Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA

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ORCID record for Marina Pasca di Magliano
For correspondence: marinapa@umich.edu

Published 29 March 2021. DOI: 10.26508/lsa.202000935

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Complement-high macrophages in pancreatic cancer

Samantha B Kemp, Nina G Steele, Eileen S Carpenter, Katelyn L Donahue, Grace G Bushnell, Aaron H Morris, Stephanie The, Sophia M Orbach, Veerin R Sirihorachai, Zeribe C Nwosu, Carlos Espinoza, Fatima Lima, Kristee Brown, Alexander A Girgis, Valerie Gunchick, Yaqing Zhang, Costas A Lyssiotis, Timothy L Frankel, Filip Bednar, Arvind Rao, Vaibhav Sahai, Lonnie D Shea, Howard C Crawford, Marina Pasca di Magliano

Life Science Alliance Mar 2021, 4 (6) e202000935; DOI: 10.26508/lsa.202000935

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Complement-high macrophages in pancreatic cancer

Samantha B Kemp, Nina G Steele, Eileen S Carpenter, Katelyn L Donahue, Grace G Bushnell, Aaron H Morris, Stephanie The, Sophia M Orbach, Veerin R Sirihorachai, Zeribe C Nwosu, Carlos Espinoza, Fatima Lima, Kristee Brown, Alexander A Girgis, Valerie Gunchick, Yaqing Zhang, Costas A Lyssiotis, Timothy L Frankel, Filip Bednar, Arvind Rao, Vaibhav Sahai, Lonnie D Shea, Howard C Crawford, Marina Pasca di Magliano

Life Science Alliance Mar 2021, 4 (6) e202000935; DOI: 10.26508/lsa.202000935

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