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Research Articles
NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membraneAmong the RAS isoforms, NRAS uniquely requires carboxyl methylation by ICMT for delivery to the plasma membrane because of having only a single palmitoylation as a second targeting signal.
Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen responseThis work shows that activation of the main cellular stress response pathway is responsible for antiestrogen resistance in breast cancer, a process that is reversible.
A systems-based method to repurpose marketed therapeutics for antiviral use: a SARS-CoV-2 case studyThis study describes complementary network-based and sequence similarity methods to identify drug repurposing opportunities predicted to directly target viral proteins, highlighting results for five human pathogens.
Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasisA renal CD169++ resident macrophage subpopulation controls Candida albicans growth, severe kidney inflammation, and immunopathology during acute systemic candidiasis.
GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification programThis work shows that GATA transcription factors transduce the BMP signaling and, with SOX17 and TFAP2C, induce the human germ-cell fate, delineating the mechanism for human germ-cell specification.
nNOS regulates ciliated cell polarity, ciliary beat frequency, and directional flow in mouse tracheaDirectional flow of mucus across the mucociliary epithelium enables the clearance of the airway. This study shows that nNOS supports the flow by regulating the planar polarity and ciliary beat frequency of ciliated cells in the tracheal epithelium.
The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic isletsZacarías-Fluck, et al identify and validate the Wnt receptor Fzd9 as a key effector of Myc-Wnt signaling cross-talk in a mouse model of Myc-driven pancreatic insulinomas.
Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastomaVideo and gene expression analyses coupled with the RNAi technique reveal microtubule-dependent, neuronal-like nucleokinetic migration in a noradrenergic type of neuroblastoma, providing a glimpse into the mechanism by which noradrenergic neuroblastoma cells may spread.
PieParty: visualizing cells from scRNA-seq data as pie chartsPieParty visualizes every cell in scRNA-seq experiments as pie charts, where every slice of a pie chart corresponds to the expression of a single gene.
Comparative profiling of stress granule clearance reveals differential contributions of the ubiquitin systemThis study shows that ubiquitin conjugates associate with various types of stress granules and that an active ubiquitin system is required for the efficient clearance of some types of stress granules.
Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidaseThe findings show that increased lysyl oxidase abundance is causal for the elevated arterial stiffness present in the arteries of Hutchinson–Gilford Progeria Syndrome mice. Pharmacologic inhibition of lysyl oxidase improves cardiac dysfunction and restores arterial compliance.
Dendritic cell entry to lymphatic capillaries is orchestrated by CD44 and the hyaluronan glycocalyxCD44 anchors the hyaluronan glycocalyx on migrating dendritic cells to permit docking to the endothelial receptor LYVE-1, thus orchestrating lymphatic trafficking through modulating glycocalyx density.
Comparative genomics of Glandirana rugosa using unsupervised AI reveals a high CG frequencyGenome sequencing of a unique frog (Glandirana rugosa) having XY/ZW systems within the species and comparative genomics with other six frogs were performed using a batch-learning self-organizing map, which is unsupervised AI for oligonucleotide compositions, to clarify its genome characteristics.
Phylo-geo-network and haplogroup analysis of 611 novel coronavirus (SARS-CoV-2) genomes from IndiaEvolution of SARS-CoV-2 in India across 51 haplogroups based on 152 parsimony informative sites revealed B6 and B1 (Pangolin) and A2a (Covidex) as the most prevalent lineage and clade, respectively.
LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockadePathogenic LRRK2 phosphorylation of Rab10 GTPase dramatically redistributes Myosin Va and RILPL2 proteins to the mother centriole and sequesters Myosin Va at that location in a manner that likely interferes with its role in ciliogenesis.
Mapping the micro-proteome of the nuclear lamina and lamina-associated domainsThe nuclear lamina provides structure to the nucleus and serves as an interface between the cytoskeleton and large heterochromatin domains called LADs. This study describes the microproteome of this LAD/lamina interface.
