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Table of Contents

May 2021 | Volume 4, No. 5

Research Articles

  • NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane
    Open Access
    NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane

    Ian M Ahearn, Helen R Court, Farid Siddiqui, Daniel Abankwa, Mark R Philips

    Ian M Ahearn ... Mark R Philips

    Published 12 February 2021

    Among the RAS isoforms, NRAS uniquely requires carboxyl methylation by ICMT for delivery to the plasma membrane because of having only a single palmitoylation as a second targeting signal.

  • Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response
    Open Access
    Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response

    Maruhen AD Silveira, Christophe Tav, Félix-Antoine Bérube-Simard, Tania Cuppens, Mickaël Leclercq, Éric Fournier, Maxime C Côté, Arnaud Droit, Steve Bilodeau

    Maruhen AD Silveira ... Steve Bilodeau

    Published 16 February 2021

    This work shows that activation of the main cellular stress response pathway is responsible for antiestrogen resistance in breast cancer, a process that is reversible.

  • A systems-based method to repurpose marketed therapeutics for antiviral use: a SARS-CoV-2 case study
    Open Access
    A systems-based method to repurpose marketed therapeutics for antiviral use: a SARS-CoV-2 case study

    Mengran Wang, Johanna B Withers, Piero Ricchiuto, Ivan Voitalov, Michael McAnally, Helia N Sanchez, Alif Saleh, Viatcheslav R Akmaev, Susan Dina Ghiassian

    Mengran Wang ... Susan Dina Ghiassian

    Published 16 February 2021

    This study describes complementary network-based and sequence similarity methods to identify drug repurposing opportunities predicted to directly target viral proteins, highlighting results for five human pathogens.

  • Renal CD169<sup>++</sup> resident macrophages are crucial for protection against acute systemic candidiasis
    Open Access
    Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis

    Yi Juan Teo, See Liang Ng, Keng Wai Mak, Yolanda Aphrilia Setiagani, Qi Chen, Sajith Kumar Nair, Jianpeng Sheng, Christiane Ruedl

    Yi Juan Teo ... Christiane Ruedl

    Published 19 February 2021

    A renal CD169++ resident macrophage subpopulation controls Candida albicans growth, severe kidney inflammation, and immunopathology during acute systemic candidiasis.

  • GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program
    Open Access
    GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program

    Yoji Kojima, Chika Yamashiro, Yusuke Murase, Yukihiro Yabuta, Ikuhiro Okamoto, Chizuru Iwatani, Hideaki Tsuchiya, Masataka Nakaya, Tomoyuki Tsukiyama, Tomonori Nakamura, Takuya Yamamoto, Mitinori Saitou

    Yoji Kojima ... Mitinori Saitou

    Published 19 February 2021

    This work shows that GATA transcription factors transduce the BMP signaling and, with SOX17 and TFAP2C, induce the human germ-cell fate, delineating the mechanism for human germ-cell specification.

  • nNOS regulates ciliated cell polarity, ciliary beat frequency, and directional flow in mouse trachea
    Open Access
    nNOS regulates ciliated cell polarity, ciliary beat frequency, and directional flow in mouse trachea

    Anatoly Mikhailik, Tatyana V Michurina, Krikor Dikranian, Stephen Hearn, Vladimir I Maxakov, Saul S Siller, Ken-Ichi Takemaru, Grigori Enikolopov, Natalia Peunova

    Anatoly Mikhailik ... Natalia Peunova

    Published 2 March 2021

    Directional flow of mucus across the mucociliary epithelium enables the clearance of the airway. This study shows that nNOS supports the flow by regulating the planar polarity and ciliary beat frequency of ciliated cells in the tracheal epithelium.

  • The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets
    Open Access
    The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets

    Mariano F Zacarías-Fluck, Toni Jauset, Sandra Martínez-Martín, Jastrinjan Kaur, Sílvia Casacuberta-Serra, Daniel Massó-Vallés, Erika Serrano del Pozo, Génesis Martín-Fernández, Íñigo González-Larreategui, Sergio López-Estévez, Lamorna Brown-Swigart, Marie-Eve Beaulieu, Jonathan R Whitfield, Babita Madan, David M Virshup, Gerard I Evan, Laura Soucek

    Mariano F Zacarías-Fluck ... Laura Soucek

    Published 2 March 2021

    Zacarías-Fluck, et al identify and validate the Wnt receptor Fzd9 as a key effector of Myc-Wnt signaling cross-talk in a mouse model of Myc-driven pancreatic insulinomas.

  • Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma
    Open Access
    Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma

    Elena A Afanasyeva, Moritz Gartlgruber, Tatsiana Ryl, Bieke Decaesteker, Geertrui Denecker, Gregor Mönke, Umut H Toprak, Andres Florez, Alica Torkov, Daniel Dreidax, Carl Herrmann, Konstantin Okonechnikov, Sara Ek, Ashwini Kumar Sharma, Vitaliya Sagulenko, Frank Speleman, Kai-Oliver Henrich, Frank Westermann

    Elena A Afanasyeva ... Frank Westermann

    Published 3 March 2021

    Video and gene expression analyses coupled with the RNAi technique reveal microtubule-dependent, neuronal-like nucleokinetic migration in a noradrenergic type of neuroblastoma, providing a glimpse into the mechanism by which noradrenergic neuroblastoma cells may spread.

  • PieParty: visualizing cells from scRNA-seq data as pie charts
    Open Access
    PieParty: visualizing cells from scRNA-seq data as pie charts

    Stefan Kurtenbach, James J Dollar, Anthony M Cruz, Michael A Durante, Christina L Decatur, J William Harbour

    Stefan Kurtenbach ... J William Harbour

    Published 5 March 2021

    PieParty visualizes every cell in scRNA-seq experiments as pie charts, where every slice of a pie chart corresponds to the expression of a single gene.

  • Comparative profiling of stress granule clearance reveals differential contributions of the ubiquitin system
    Open Access
    Comparative profiling of stress granule clearance reveals differential contributions of the ubiquitin system

    Nazife Tolay, Alexander Buchberger

    Nazife Tolay ... Alexander Buchberger

    Published 9 March 2021

    This study shows that ubiquitin conjugates associate with various types of stress granules and that an active ubiquitin system is required for the efficient clearance of some types of stress granules.

  • Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase
    Open Access
    Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase

    Ryan von Kleeck, Emilia Roberts, Paola Castagnino, Kyle Bruun, Sonja A Brankovic, Elizabeth A Hawthorne, Tina Xu, John W Tobias, Richard K Assoian

    Ryan von Kleeck ... Richard K Assoian

    Published 9 March 2021

    The findings show that increased lysyl oxidase abundance is causal for the elevated arterial stiffness present in the arteries of Hutchinson–Gilford Progeria Syndrome mice. Pharmacologic inhibition of lysyl oxidase improves cardiac dysfunction and restores arterial compliance.

  • Dendritic cell entry to lymphatic capillaries is orchestrated by CD44 and the hyaluronan glycocalyx
    Open Access
    Dendritic cell entry to lymphatic capillaries is orchestrated by CD44 and the hyaluronan glycocalyx

    Louise A Johnson, Suneale Banerji, B Christoffer Lagerholm, David G Jackson

    Louise A Johnson ... David G Jackson

    Published 9 March 2021

    CD44 anchors the hyaluronan glycocalyx on migrating dendritic cells to permit docking to the endothelial receptor LYVE-1, thus orchestrating lymphatic trafficking through modulating glycocalyx density.

  • Comparative genomics of <em>Glandirana rugosa</em> using unsupervised AI reveals a high CG frequency
    Open Access
    Comparative genomics of Glandirana rugosa using unsupervised AI reveals a high CG frequency

    Yukako Katsura, Toshimichi Ikemura, Rei Kajitani, Atsushi Toyoda, Takehiko Itoh, Mitsuaki Ogata, Ikuo Miura, Kennosuke Wada, Yoshiko Wada, Yoko Satta

    Yukako Katsura ... Yoko Satta

    Published 12 March 2021

    Genome sequencing of a unique frog (Glandirana rugosa) having XY/ZW systems within the species and comparative genomics with other six frogs were performed using a batch-learning self-organizing map, which is unsupervised AI for oligonucleotide compositions, to clarify its genome characteristics.

  • Phylo-geo-network and haplogroup analysis of 611 novel coronavirus (SARS-CoV-2) genomes from India
    Open Access
    Phylo-geo-network and haplogroup analysis of 611 novel coronavirus (SARS-CoV-2) genomes from India

    Rezwanuzzaman Laskar, Safdar Ali

    Rezwanuzzaman Laskar ... Safdar Ali

    Published 16 March 2021

    Evolution of SARS-CoV-2 in India across 51 haplogroups based on 152 parsimony informative sites revealed B6 and B1 (Pangolin) and A2a (Covidex) as the most prevalent lineage and clade, respectively.

  • LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade
    Open Access
    LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade

    Herschel S Dhekne, Izumi Yanatori, Edmundo G Vides, Yuriko Sobu, Federico Diez, Francesca Tonelli, Suzanne R Pfeffer

    Herschel S Dhekne ... Suzanne R Pfeffer

    Published 16 March 2021

    Pathogenic LRRK2 phosphorylation of Rab10 GTPase dramatically redistributes Myosin Va and RILPL2 proteins to the mother centriole and sequesters Myosin Va at that location in a manner that likely interferes with its role in ciliogenesis.

  • Mapping the micro-proteome of the nuclear lamina and lamina-associated domains
    Open Access
    Mapping the micro-proteome of the nuclear lamina and lamina-associated domains

    Xianrong Wong, Jevon A Cutler, Victoria E Hoskins, Molly Gordon, Anil K Madugundu, Akhilesh Pandey, Karen L Reddy

    Xianrong Wong ... Karen L Reddy

    Published 23 March 2021

    The nuclear lamina provides structure to the nucleus and serves as an interface between the cytoskeleton and large heterochromatin domains called LADs. This study describes the microproteome of this LAD/lamina interface.

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Volume 4, No. 5
May 2021
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