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Table of Contents

April 2021 | Volume 4, No. 4

Research Articles

  • A novel role of DNA polymerase λ in translesion synthesis in conjunction with DNA polymerase ζ
    Open Access
    A novel role of DNA polymerase λ in translesion synthesis in conjunction with DNA polymerase ζ

    Jung-Hoon Yoon, Debashree Basu, Karthi Sellamuthu, Robert E Johnson, Satya Prakash, Louise Prakash

    Jung-Hoon Yoon ... Louise Prakash

    Published 29 January 2021

    As an integral scaffolding component of DNA polymerase (Pol) zeta, Pol lambda adapts Pol zeta–dependent translesion synthesis to operate in a predominantly error-free manner in human cells.

  • A novel <em>canis lupus familiaris</em> reference genome improves variant resolution for use in breed-specific GWAS
    Open Access
    A novel canis lupus familiaris reference genome improves variant resolution for use in breed-specific GWAS

    Robert A Player, Ellen R Forsyth, Kathleen J Verratti, David W Mohr, Alan F Scott, Christopher E Bradburne

    Robert A Player ... Christopher E Bradburne

    Published 29 January 2021

    This paper describes the economical optimization of DNA extraction, short and long read sequencing, and bioinformatic assembly, which in turn improves mapping and variant resolution of short-read sequenced, same-breed dogs for association studies. This methodology is applicable for any investigators planning a genome-wide association study.

  • Harnessing reaction-based probes to preferentially target pancreatic β-cells and β-like cells
    Open Access
    Harnessing reaction-based probes to preferentially target pancreatic β-cells and β-like cells

    Sevim Kahraman, Debasish Manna, Ercument Dirice, Basudeb Maji, Jonnell Small, Bridget K Wagner, Amit Choudhary, Rohit N Kulkarni

    Sevim Kahraman ... Rohit N Kulkarni

    Published 29 January 2021

    The study uses a reaction probe to target insulin-expressing pancreatic β-cells and β-like cells derived from pluripotent stem cells by harnessing high intracellular Zn(II) concentration.

  • Functional interaction between macrophages and hepatocytes dictate the outcome of liver fibrosis
    Open Access
    Functional interaction between macrophages and hepatocytes dictate the outcome of liver fibrosis

    Min Xie, Ren Hui Chia, Dan Li, Fanny Xueting Teo, Christian Krueger, Kanaga Sabapathy

    Min Xie ... Kanaga Sabapathy

    Published 29 January 2021

    Xie et al demonstrate opposite outcomes on liver fibrosis due to deletion of c-Jun in hepatocytes alone or along with Kupffer cells, highlighting the functional interaction between these cell types in regulating the fibrotic process, dictated by c-Jun.

  • TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibition
    Open Access
    TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibition

    María Luisa Franco, Irmina García-Carpio, Raquel Comaposada-Baró, Juan J Escribano-Saiz, Lucía Chávez-Gutiérrez, Marçal Vilar

    María Luisa Franco ... Marçal Vilar

    Published 3 February 2021

    The findings shed light into the adverse effects of GSIs observed in the Alzheimer’s field and explain, at least in part, the unexpected worsening in cognition observed in the semagacestat Phase 3 trial.

  • Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control
    Open Access
    Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control

    Lea Bühler, Adriano Maida, Elena Sophie Vogl, Anastasia Georgiadi, Andrea Takacs, Oliver Kluth, Annette Schürmann, Annette Feuchtinger, Christine von Toerne, Foivos-Filippos Tsokanos, Katarina Klepac, Gretchen Wolff, Minako Sakurai, Bilgen Ekim Üstünel, Peter Nawroth, Stephan Herzig

    Lea Bühler ... Stephan Herzig

    Published 3 February 2021

    Thorough preclinical evaluation reveals a negligible role of lipocalin 13 in systemic glucose and lipid metabolism.

  • 1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells
    Open Access
    1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells

    Yuji Itoh, Shiori Iida, Sachiko Tamura, Ryosuke Nagashima, Kentaro Shiraki, Tatsuhiko Goto, Kayo Hibino, Satoru Ide, Kazuhiro Maeshima

    Yuji Itoh ... Kazuhiro Maeshima

    Published 3 February 2021

    Alcohol, 1,6-hexanediol, is widely used for melting liquid droplets formed by liquid0–liquid phase separation; however, it can also seriously affect cells by immobilizing and condensing chromatin.

  • Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family
    Open Access
    Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family

    Tânia Filipa Custódio, Peter Aasted Paulsen, Kelly May Frain, Bjørn Panyella Pedersen

    Tânia Filipa Custódio ... Bjørn Panyella Pedersen

    Published 3 February 2021

    A new structure of GLUT1, compared with GLUT3, can explain substrate affinity differences, and provide a functional rationale for key structural motifs that define the universal Sugar Porter family.

  • TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection
    Open Access
    TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection

    Diego Peretti, Heather L Smith, Nicholas Verity, Ibrahim Humoud, Lis de Weerd, Dean P Swinden, Joseph Hayes, Giovanna R Mallucci

    Diego Peretti ... Giovanna R Mallucci

    Published 9 February 2021

    The neuroprotective effects of the cold-shock protein RBM3 have broad appeal for therapy. RBM3 induction through cooling occurs through a non-canonical pattern of TrkB signaling. The pathway can now be targeted pharmacologically for RBM3-mediated neuroprotection without the need for cooling.

  • CDCP1 promotes compensatory renal growth by integrating Src and Met signaling
    Open Access
    CDCP1 promotes compensatory renal growth by integrating Src and Met signaling

    Kentaro Kajiwara, Shotaro Yamano, Kazuhiro Aoki, Daisuke Okuzaki, Kunio Matsumoto, Masato Okada

    Kentaro Kajiwara ... Masato Okada

    Published 11 February 2021

    CDCP1 promotes HGF-induced compensatory renal growth by focally and temporally integrating Src and Met-STAT3 signaling in lipid rafts.

  • Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase
    Open Access
    Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase

    Cheng-Han Ho, Yoshimasa Takizawa, Wataru Kobayashi, Yasuhiro Arimura, Hiroshi Kimura, Hitoshi Kurumizaka

    Cheng-Han Ho ... Hitoshi Kurumizaka

    Published 11 February 2021

    Cryo-EM structures of the human SET8–nucleosome complexes reveal the mechanism by which the SET8 methyltransferase binds the nucleosome and specifically recognizes the histone H4 lysine-20 residue.

  • A conserved PI(4,5)P2–binding domain is critical for immune regulatory function of DOCK8
    Open Access
    A conserved PI(4,5)P2–binding domain is critical for immune regulatory function of DOCK8

    Tetsuya Sakurai, Mutsuko Kukimoto-Niino, Kazufumi Kunimura, Nana Yamane, Daiji Sakata, Ryosuke Aihara, Tomoharu Yasuda, Shigeyuki Yokoyama, Mikako Shirouzu, Yoshinori Fukui, Takehito Uruno

    Tetsuya Sakurai ... Takehito Uruno

    Published 11 February 2021

    This study uncovers a critical role of DOCK8 in coupling PI(4,5)P2 signaling with Cdc42 activation through its DHR-1 domain during interstitial leukocyte migration.

  • SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamsters
    Open Access
    SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamsters

    Prabhuanand Selvaraj, Christopher Z Lien, Shufeng Liu, Charles B Stauft, Ivette A Nunez, Mario Hernandez, Eric Nimako, Mario A Ortega, Matthew F Starost, John U Dennis, Tony T Wang

    Prabhuanand Selvaraj ... Tony T Wang

    Published 11 February 2021

    Using an aged Syrian hamster model, which develops severe morbidity upon SARS-CoV-2 infection including death, we demonstrated that the immunity induced by a natural infection not only protects hamsters from reinfection but also significantly limits transmission via close contact.

  • Short-term IL-15 priming leaves a long-lasting signalling imprint in mouse NK cells independently of a metabolic switch
    Open Access
    Short-term IL-15 priming leaves a long-lasting signalling imprint in mouse NK cells independently of a metabolic switch

    Thuy T Luu, Laurent Schmied, Ngoc-Anh Nguyen, Clotilde Wiel, Stephan Meinke, Dara K Mohammad, Martin Bergö, Evren Alici, Nadir Kadri, Sridharan Ganesan, Petter Höglund

    Thuy T Luu ... Petter Höglund

    Published 16 February 2021

    NK cell reactivity is dynamically regulated by IL-15, and NK cells do not need more than a few minutes of exposure to remember the cytokine for several hours.

  • Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis
    Open Access
    Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis

    Arun Pal, Benedikt Kretner, Masin Abo-Rady, Hannes Glaβ, Banaja P Dash, Marcel Naumann, Julia Japtok, Nicole Kreiter, Ashutosh Dhingra, Peter Heutink, Tobias M Böckers, René Günther, Jared Sterneckert, Andreas Hermann

    Arun Pal ... Andreas Hermann

    Published 22 February 2021

    Axonal trafficking deficits and neurodegeneration in C9ORF72 motoneurons are mediated by GOF and LOF mechanisms with RNA foci and DPRs as upstream events, whereas DNA damage appears downstream.

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Volume 4, No. 4
April 2021
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