Article Figures & Data
Figures
- Figure 1. Percentage of tumors in each of the F-1 strains observed by gross anatomical observation upon autopsy.
Homozygous C57/Bl6 male mice with a R172H Tp53 mutation were crossed to seven different wild-type strains of mice as indicated in the figure. At various times after birth indicated in the time scale, some mice from each of the F-1 strains were euthanized and autopsied for the presence of gross anatomical tumors or enlarged organs in many different tissues. The graphs for each F-1 mouse strains are the cumulative percentage of the total mice in the F-1 cohort (given in the text) over a 20- to 22-mo period.
- Figure 2. Percentage of tumors in each of the different F-1 strains of mice observed by histopathological analysis of the mice indicated in Fig 1 .
The genetic crosses and the times of euthanasia of individual mice from each F-1 strains are as indicated in Fig 1. The anatomical tumors identified in Fig 1 were fixed, embedded, and sectioned and evaluated by a pathologist for both benign and malignant tumors and the tissue type. (A) Percentage of tumors in each of the different F-1 strains of mice. (B) The representative H&E images of tumors.
- Figure 3. Differences in survival in A/J and NOD F-1 mice with a heterozygous germ line mutant Tp53 gene.
Male C57Bl/6 mice homozygous for the R172H Tp53 mutation were crossed with A/J mice and NOD mice, respectively. Life span of mice in each cohort was recorded and the histopathological analysis was performed by a pathologist. In A/J F-1 cohort, 46 mice developed cancers and in NOD F-1 cohort, 37 mice developed cancers.
- Figure 4. Tumor penetrance, sexual dimorphism, and multiple tumors in the different F-1 mice from the crosses in Fig 1.
Tables
- Table 1.
The tumor spectrum and incidence of the different strains of F-1 mice with Tp53 mutations.
Hybrid Strain Lymphoid hyperplasia/lymphoma Osteosarcoma Adenocarcinoma Spindle cell sarcoma/sarcoma Angioma/angiosarcoma Squamous carcinoma/carcinoma Hemangioma Lipoma/lipomatous tumor/liposarcoma 129SL 10% 6% 2% 0% 2% 2% 2% 2% A/J 10% 17% 3% 7% 3% 0% 0% 20% Balb/cByJ 4% 11% 13% 4% 15% 6% 2% 0% C3H 23% 8% 4% 4% 0% 0% 0% 0% DBA 21% 4% 7% 0% 4% 0% 4% 4% NOD 24% 16% 3% 8% 1% 1% 3% 0% SWR 30% 20% 11% 4% 4% 8% 1% 0% Average incidence of tumor types 18% 13% 6% 4% 4% 3% 2% 2% Total tumors (n) 58 42 21 14 14 11 6 7 The table presents the incidence of different tumor types produced by the R172H heterozygous F-1 mouse strains. Total tumors (n) are the total number of tumors for each tumor type across all strains.
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