Reduced RNA turnover as a driver of cellular senescence

Nowsheen Mullani; Yevheniia Porozhan; Adèle Mangelinck; Christophe Rachez; Mickael Costallat; Eric Batsché; Michele Goodhardt; Giovanni Cenci; Carl Mann; Christian Muchardt

doi:10.26508/lsa.202000809

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Reduced RNA turnover as a driver of cellular senescence

Nowsheen Mullani, Yevheniia Porozhan, Adèle Mangelinck, View ORCID ProfileChristophe Rachez, View ORCID ProfileMickael Costallat, View ORCID ProfileEric Batsché, Michele Goodhardt, Giovanni Cenci, View ORCID ProfileCarl Mann, View ORCID ProfileChristian Muchardt Correspondence email

Nowsheen Mullani

1Institut Pasteur, Centre National de la Recherche Scientifique (CNRS) UMR3738, Dpt Biologie du Développement et Cellules Souches, Unité de Régulation Epigénétique, Paris, France

2Sorbonne Université, Ecole Doctorale “Complexité du Vivant” (ED515), Paris, France

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Yevheniia Porozhan

1Institut Pasteur, Centre National de la Recherche Scientifique (CNRS) UMR3738, Dpt Biologie du Développement et Cellules Souches, Unité de Régulation Epigénétique, Paris, France

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Adèle Mangelinck

6Université Paris-Saclay, Commissariat à l’Énergie Atomique et aux Énergies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France

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Christophe Rachez

1Institut Pasteur, Centre National de la Recherche Scientifique (CNRS) UMR3738, Dpt Biologie du Développement et Cellules Souches, Unité de Régulation Epigénétique, Paris, France

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Mickael Costallat

1Institut Pasteur, Centre National de la Recherche Scientifique (CNRS) UMR3738, Dpt Biologie du Développement et Cellules Souches, Unité de Régulation Epigénétique, Paris, France

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Eric Batsché

1Institut Pasteur, Centre National de la Recherche Scientifique (CNRS) UMR3738, Dpt Biologie du Développement et Cellules Souches, Unité de Régulation Epigénétique, Paris, France

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Michele Goodhardt

3Institut National de la Santé et de la Recherche Médicale (INSERM) U976, Institut de Recherche Saint Louis, Université de Paris, Paris, France

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Giovanni Cenci

4Dipartimento Biologia e Biotecnologie “C. Darwin,” SAPIENZA Università di Roma, Rome, Italy

5Istituto Pasteur Italia–Fondazione Cenci Bolognetti, Rome, Italy

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Carl Mann

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Christian Muchardt

1Institut Pasteur, Centre National de la Recherche Scientifique (CNRS) UMR3738, Dpt Biologie du Développement et Cellules Souches, Unité de Régulation Epigénétique, Paris, France

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For correspondence: christian.muchardt@sorbonne-universite.fr

Published 14 January 2021. DOI: 10.26508/lsa.202000809

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RNA-driven senescence

Nowsheen Mullani, Yevheniia Porozhan, Adèle Mangelinck, Christophe Rachez, Mickael Costallat, Eric Batsché, Michele Goodhardt, Giovanni Cenci, Carl Mann, Christian Muchardt

Life Science Alliance Jan 2021, 4 (3) e202000809; DOI: 10.26508/lsa.202000809

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RNA-driven senescence

Nowsheen Mullani, Yevheniia Porozhan, Adèle Mangelinck, Christophe Rachez, Mickael Costallat, Eric Batsché, Michele Goodhardt, Giovanni Cenci, Carl Mann, Christian Muchardt

Life Science Alliance Jan 2021, 4 (3) e202000809; DOI: 10.26508/lsa.202000809

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