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Reduced RNA turnover as a driver of cellular senescence

Nowsheen Mullani, Yevheniia Porozhan, Adèle Mangelinck, View ORCID ProfileChristophe Rachez, View ORCID ProfileMickael Costallat, View ORCID ProfileEric Batsché, Michele Goodhardt, Giovanni Cenci, View ORCID ProfileCarl Mann, View ORCID ProfileChristian Muchardt  Correspondence email
Nowsheen Mullani
1Institut Pasteur, Centre National de la Recherche Scientifique (CNRS) UMR3738, Dpt Biologie du Développement et Cellules Souches, Unité de Régulation Epigénétique, Paris, France
2Sorbonne Université, Ecole Doctorale “Complexité du Vivant” (ED515), Paris, France
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Yevheniia Porozhan
1Institut Pasteur, Centre National de la Recherche Scientifique (CNRS) UMR3738, Dpt Biologie du Développement et Cellules Souches, Unité de Régulation Epigénétique, Paris, France
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Adèle Mangelinck
6Université Paris-Saclay, Commissariat à l’Énergie Atomique et aux Énergies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France
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Christophe Rachez
1Institut Pasteur, Centre National de la Recherche Scientifique (CNRS) UMR3738, Dpt Biologie du Développement et Cellules Souches, Unité de Régulation Epigénétique, Paris, France
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  • ORCID record for Christophe Rachez
Mickael Costallat
1Institut Pasteur, Centre National de la Recherche Scientifique (CNRS) UMR3738, Dpt Biologie du Développement et Cellules Souches, Unité de Régulation Epigénétique, Paris, France
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  • ORCID record for Mickael Costallat
Eric Batsché
1Institut Pasteur, Centre National de la Recherche Scientifique (CNRS) UMR3738, Dpt Biologie du Développement et Cellules Souches, Unité de Régulation Epigénétique, Paris, France
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  • ORCID record for Eric Batsché
Michele Goodhardt
3Institut National de la Santé et de la Recherche Médicale (INSERM) U976, Institut de Recherche Saint Louis, Université de Paris, Paris, France
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Giovanni Cenci
4Dipartimento Biologia e Biotecnologie “C. Darwin,” SAPIENZA Università di Roma, Rome, Italy
5Istituto Pasteur Italia–Fondazione Cenci Bolognetti, Rome, Italy
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Carl Mann
6Université Paris-Saclay, Commissariat à l’Énergie Atomique et aux Énergies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France
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Christian Muchardt
1Institut Pasteur, Centre National de la Recherche Scientifique (CNRS) UMR3738, Dpt Biologie du Développement et Cellules Souches, Unité de Régulation Epigénétique, Paris, France
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  • For correspondence: christian.muchardt@sorbonne-universite.fr
Published 14 January 2021. DOI: 10.26508/lsa.202000809
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Article Information

vol. 4 no. 3 e202000809
DOI 
https://doi.org/10.26508/lsa.202000809
PubMed 
33446491

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received June 8, 2020
  • Revision received December 22, 2020
  • Accepted December 23, 2020
  • Published online January 14, 2021.

Copyright & Usage 
© 2021 Mullani et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Nowsheen Mullani1,2,*,
  2. Yevheniia Porozhan1,*,
  3. Adèle Mangelinck6,
  4. Christophe Rachez1,
  5. Mickael Costallat1,
  6. Eric Batsché1,
  7. Michele Goodhardt3,
  8. Giovanni Cenci4,5,
  9. Carl Mann6 and
  10. Christian Muchardt1⇑
  1. 1Institut Pasteur, Centre National de la Recherche Scientifique (CNRS) UMR3738, Dpt Biologie du Développement et Cellules Souches, Unité de Régulation Epigénétique, Paris, France
  2. 2Sorbonne Université, Ecole Doctorale “Complexité du Vivant” (ED515), Paris, France
  3. 3Institut National de la Santé et de la Recherche Médicale (INSERM) U976, Institut de Recherche Saint Louis, Université de Paris, Paris, France
  4. 4Dipartimento Biologia e Biotecnologie “C. Darwin,” SAPIENZA Università di Roma, Rome, Italy
  5. 5Istituto Pasteur Italia–Fondazione Cenci Bolognetti, Rome, Italy
  6. 6Université Paris-Saclay, Commissariat à l’Énergie Atomique et aux Énergies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France
  1. Correspondence: christian.muchardt{at}sorbonne-universite.fr
  1. ↵* Nowsheen Mullani and Yevheniia Porozhan contributed equally to this work

  • Christophe Rachez, Eric Batsché, and Christian Muchardt’s present address is Institut de Biologie Paris-Seine (IBPS), Institut National de la Recherche Scientifique (CNRS) UMR8256, Paris, France

View Full Text

Funding

  • Institut Pasteur

    PTR 24-17
    C Muchardt
  • LABEX REVIVE

    C Muchardt
  • Agence Nationale de la Recherche

    15-CE14-0003
    C Muchardt
  • ANR

    17-008-02
    C Mann
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RNA-driven senescence
Nowsheen Mullani, Yevheniia Porozhan, Adèle Mangelinck, Christophe Rachez, Mickael Costallat, Eric Batsché, Michele Goodhardt, Giovanni Cenci, Carl Mann, Christian Muchardt
Life Science Alliance Jan 2021, 4 (3) e202000809; DOI: 10.26508/lsa.202000809

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RNA-driven senescence
Nowsheen Mullani, Yevheniia Porozhan, Adèle Mangelinck, Christophe Rachez, Mickael Costallat, Eric Batsché, Michele Goodhardt, Giovanni Cenci, Carl Mann, Christian Muchardt
Life Science Alliance Jan 2021, 4 (3) e202000809; DOI: 10.26508/lsa.202000809
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Volume 4, No. 3
March 2021
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