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Table of Contents

March 2021 | Volume 4, No. 3

Research Articles

  • Paneth cell–derived growth factors support tumorigenesis in the small intestine
    Open Access
    Paneth cell–derived growth factors support tumorigenesis in the small intestine

    Qing Chen, Kohei Suzuki, Luis Sifuentes-Dominguez, Naoteru Miyata, Jie Song, Adam Lopez, Petro Starokadomskyy, Purva Gopal, Igor Dozmorov, Shuai Tan, Bujun Ge, Ezra Burstein

    Qing Chen ... Ezra Burstein

    Published 28 December 2020

    Paneth cells, known for their production of antimicrobial peptides and growth factors in the gut epithelium, are found to play a key role in intestinal tumor formation through secretion of Wnt3.

  • HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails
    Open Access
    HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails

    Pablo Barbeito, Yuki Tachibana, Raquel Martin-Morales, Paula Moreno, Kirk Mykytyn, Tetsuo Kobayashi, Francesc R Garcia-Gonzalo

    Pablo Barbeito ... Francesc R Garcia-Gonzalo

    Published 28 December 2020

    Ciliary accumulation of G protein–coupled receptors HTR6 and SSTR3 depends on redundant ciliary targeting sequences acting via ciliary trafficking adapters TULP3 and RABL2.

  • Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formation
    Open Access
    Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formation

    Nicholas Vrettos, Manolis Maragkakis, Panagiotis Alexiou, Paraskevi Sgourdou, Fadia Ibrahim, Daniel Palmieri, Yohei Kirino, Zissimos Mourelatos

    Nicholas Vrettos ... Zissimos Mourelatos

    Published 29 December 2020

    N-terminal Aub arginines are dispensable for primary piRNA biogenesis but essential for amplification; their symmetric dimethylation is required for germline inheritance but not for piRNA amplification.

  • The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells
    Open Access
    The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells

    Maria Inês Alvelos, Mirko Brüggemann, FX Reymond Sutandy, Jonàs Juan-Mateu, Maikel Luis Colli, Anke Busch, Miguel Lopes, Ângela Castela, Annemieke Aartsma-Rus, Julian König, Kathi Zarnack, Décio L Eizirik

    Maria Inês Alvelos ... Décio L Eizirik

    Published 29 December 2020

    The RNA-binding protein SRSF6 recognizes a purine-rich consensus motif consisting of GAA triplets, and its downregulation in human pancreatic β-cells affects alternative splicing in a position-dependent manner.

  • The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions
    Open Access
    The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions

    Baskar Chakrapani, Mohd Imran K Khan, Rajashekar Varma Kadumuri, Somlee Gupta, Mamta Verma, Sharad Awasthi, Gayathri Govindaraju, Arun Mahesh, Arumugam Rajavelu, Sreenivas Chavali, Arunkumar Dhayalan

    Baskar Chakrapani ... Arunkumar Dhayalan

    Published 29 December 2020

    The uncharacterized protein FAM47E interacts with and stabilizes the protein arginine methyltransferase PRMT5, regulating its epigenetic functions thereby modulating target gene expression.

  • Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse models
    Open Access
    Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse models

    Chang S Chan, Yvonne Sun, Hua Ke, Yuhan Zhao, Merzu Belete, Cen Zhang, Zhaohui Feng, Arnold J Levine, Wenwei Hu

    Chang S Chan ... Wenwei Hu

    Published 29 December 2020

    This study used mice heterozygous for Tp53 mutations with different genetic backgrounds to investigate the genetic or stochastic factors that modify the penetrance of tumor formation by Tp53 mutation.

  • The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells
    Open Access
    The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells

    Li Ding, Maciej Paszkowski-Rogacz, Jovan Mircetic, Debojyoti Chakraborty, Frank Buchholz

    Li Ding ... Frank Buchholz

    Published 29 December 2020

    Using ChIP-seq and functional genomic analyses, the study shows that the Paf1 complex occupies transcriptional enhancers and positively regulates their activity.

  • Tissue-selective alternate promoters guide NLRP6 expression
    Open Access
    Tissue-selective alternate promoters guide NLRP6 expression

    Nathan A Bracey, Jaye M Platnich, Arthur Lau, Hyunjae Chung, M Eric Hyndman, Justin A MacDonald, Justin Chun, Paul L Beck, Stephen E Girardin, Paul MK Gordon, Daniel A Muruve

    Nathan A Bracey ... Daniel A Muruve

    Published 29 December 2020

    The NLRP6 innate immune sensor is regulated by tissue-selective alternate promoters that facilitate translational gene silencing outside of the intestinal epithelium in both humans and mice.

  • Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1
    Open Access
    Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1

    Helena Silva Cascales, Kamila Burdova, Anna Middleton, Vladislav Kuzin, Erik Müllers, Henriette Stoy, Laura Baranello, Libor Macurek, Arne Lindqvist

    Helena Silva Cascales ... Arne Lindqvist

    Published 5 January 2021

    Main mitotic kinases as PLK1 are activated at the S/G2 transition. A change in Cyclin A2 localisation at the S/G2 transition enables activation of PLK1.

  • MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility
    Open Access
    MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility

    Shibojyoti Lahiri, Wasim Aftab, Lena Walenta, Leena Strauss, Matti Poutanen, Artur Mayerhofer, Axel Imhof

    Shibojyoti Lahiri ... Axel Imhof

    Published 6 January 2021

    In situ proteomics of male infertility.

  • Reduced RNA turnover as a driver of cellular senescence
    Open Access
    Reduced RNA turnover as a driver of cellular senescence

    Nowsheen Mullani, Yevheniia Porozhan, Adèle Mangelinck, Christophe Rachez, Mickael Costallat, Eric Batsché, Michele Goodhardt, Giovanni Cenci, Carl Mann, Christian Muchardt

    Nowsheen Mullani ... Christian Muchardt

    Published 14 January 2021

    RNAs originating from transcription upstream and downstream of genes accumulate in the cytoplasm of a subset of senescent cells, suggesting an RNA alternative to cytoplasmic DNA in the triggering of senescence.

  • ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway
    Open Access
    ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway

    Tianyao Xiao, Viplendra PS Shakya, Adam L Hughes

    Tianyao Xiao ... Adam L Hughes

    Published 21 January 2021

    The GET pathway is required to target non-imported mitochondrial carrier proteins to the endoplasmic reticulum, which prevents their deposition into Hsp42-dependent protein foci.

  • Insulin signaling mediates neurodegeneration in glioma
    Open Access
    Insulin signaling mediates neurodegeneration in glioma

    Patricia Jarabo, Carmen de Pablo, Héctor Herranz, Francisco Antonio Martín, Sergio Casas-Tintó

    Patricia Jarabo ... Sergio Casas-Tintó

    Published 1 February 2021

    Tumoral cells secrete an antagonist that attenuates insulin signaling in neurons. It induces mitochondrial defects and synapse loss; restoring neuronal insulin activity rescues neurodegeneration.

Methods

  • A FIJI macro for quantifying pattern in extracellular matrix
    Open Access
    A FIJI macro for quantifying pattern in extracellular matrix

    Esther Wershof, Danielle Park, David J Barry, Robert P Jenkins, Antonio Rullan, Anna Wilkins, Karin Schlegelmilch, Ioannis Roxanis, Kurt I Anderson, Paul A Bates, Erik Sahai

    Esther Wershof ... Erik Sahai

    Published 27 January 2021

    This work provides a quantitative tool for the analysis of fibrillar patterns in biology. We demonstrates its utility on in vitro generated extracellular matrices, mouse tissues, and patient samples. The tool is already publicly available to the research community.

Correction

  • Open Access
    Correction: MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility

    Shibojyoti Lahiri, Wasim Aftab, Lena Walenta, Leena Strauss, Matti Poutanen, Artur Mayerhofer, Axel Imhof

    Shibojyoti Lahiri ... Axel Imhof

    Published 21 January 2021

    Correction

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Volume 4, No. 3
March 2021
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