Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression

André F Rendeiro; Joseph Casano; Charles Kyriakos Vorkas; Harjot Singh; Ayana Morales; Robert A DeSimone; Grant B Ellsworth; Rosemary Soave; Shashi N Kapadia; Kohta Saito; Christopher D Brown; JingMei Hsu; Christopher Kyriakides; Steven Chiu; Luca Vincenzo Cappelli; Maria Teresa Cacciapuoti; Wayne Tam; Lorenzo Galluzzi; Paul D Simonson; Olivier Elemento; Mirella Salvatore; Giorgio Inghirami

doi:10.26508/lsa.202000955

Research Article

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Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression

André F Rendeiro, Joseph Casano, Charles Kyriakos Vorkas, Harjot Singh, Ayana Morales, View ORCID ProfileRobert A DeSimone, View ORCID ProfileGrant B Ellsworth, Rosemary Soave, Shashi N Kapadia, Kohta Saito, View ORCID ProfileChristopher D Brown, JingMei Hsu, Christopher Kyriakides, Steven Chiu, View ORCID ProfileLuca Vincenzo Cappelli, Maria Teresa Cacciapuoti, Wayne Tam, Lorenzo Galluzzi, Paul D Simonson, Olivier Elemento Correspondence email, View ORCID ProfileMirella Salvatore Correspondence email, View ORCID ProfileGiorgio Inghirami Correspondence email

André F Rendeiro

1Institute of Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA

2Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA

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Joseph Casano

3Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA

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Charles Kyriakos Vorkas

4Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA

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Harjot Singh

4Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA

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Ayana Morales

4Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA

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Robert A DeSimone

3Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA

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ORCID record for Robert A DeSimone

Grant B Ellsworth

4Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA

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Rosemary Soave

4Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA

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Shashi N Kapadia

4Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA

5Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA

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Kohta Saito

4Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA

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Christopher D Brown

4Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA

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JingMei Hsu

6Division of Hematology/Oncology, Department of Medicine Weill Cornell Medicine, New York, NY, USA

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Christopher Kyriakides

7Department of Rehabilitation Medicine at New York University Grossman School of Medicine New York, NY, USA

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Steven Chiu

3Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA

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Luca Vincenzo Cappelli

3Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA

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Maria Teresa Cacciapuoti

3Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA

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Wayne Tam

3Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA

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Lorenzo Galluzzi

2Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA

8Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA

9Sandra and Edward Meyer Cancer Center, New York, NY, USA

10Department of Dermatology, Yale School of Medicine, New Haven, CT, USA

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Paul D Simonson

3Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA

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Olivier Elemento

1Institute of Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA

2Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA

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For correspondence: ole2001@med.cornell.edu

Mirella Salvatore

5Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA

11Division of Public Health Programs, Department of Medicine, Weill Cornell Medicine, New York, NY, USA

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For correspondence: mis2053@med.cornell.edu

Giorgio Inghirami

3Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA

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ORCID record for Giorgio Inghirami
For correspondence: ggi9001@med.cornell.edu

Published 24 December 2020. DOI: 10.26508/lsa.202000955

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COVID-19 immune profiling and prediction

André F Rendeiro, Joseph Casano, Charles Kyriakos Vorkas, Harjot Singh, Ayana Morales, Robert A DeSimone, Grant B Ellsworth, Rosemary Soave, Shashi N Kapadia, Kohta Saito, Christopher D Brown, JingMei Hsu, Christopher Kyriakides, Steven Chiu, Luca Vincenzo Cappelli, Maria Teresa Cacciapuoti, Wayne Tam, Lorenzo Galluzzi, Paul D Simonson, Olivier Elemento, Mirella Salvatore, Giorgio Inghirami

Life Science Alliance Dec 2020, 4 (2) e202000955; DOI: 10.26508/lsa.202000955

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COVID-19 immune profiling and prediction

Life Science Alliance Dec 2020, 4 (2) e202000955; DOI: 10.26508/lsa.202000955

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