Engineered RNA biosensors enable ultrasensitive SARS-CoV-2 detection in a simple color and luminescence assay

Anirudh Chakravarthy; Anirudh Nandakumar; Geen George; Shyamsundar Ranganathan; Suchitta Umashankar; Nishan Shettigar; Dasaradhi Palakodeti; Akash Gulyani; Arati Ramesh

doi:10.26508/lsa.202101213

Research Article

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Engineered RNA biosensors enable ultrasensitive SARS-CoV-2 detection in a simple color and luminescence assay

Anirudh Chakravarthy, Anirudh Nandakumar, Geen George, Shyamsundar Ranganathan, Suchitta Umashankar, Nishan Shettigar, View ORCID ProfileDasaradhi Palakodeti, Akash Gulyani Correspondence email, View ORCID ProfileArati Ramesh Correspondence email

Anirudh Chakravarthy

1InStem–Institute for Stem Cell Science and Regenerative Medicine, Bangalore, India

2SASTRA University, Tirumalaisamudram, Thanjavur, India

Roles: Conceptualization, Validation, Investigation, Visualization, Methodology, Writing—original draft, review, and editing

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Anirudh Nandakumar

3National Centre for Biological Sciences, GKVK Campus, Bangalore, India

4Trans-Disciplinary Health Sciences and Technology, Bangalore, India

Roles: Conceptualization, Data curation, Software, Formal analysis, Visualization, Writing—original draft, review, and editing

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Geen George

1InStem–Institute for Stem Cell Science and Regenerative Medicine, Bangalore, India

Roles: Conceptualization, Validation, Investigation, Visualization, Methodology, Writing—original draft, review, and editing

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Shyamsundar Ranganathan

5Red Hat, Inc., Westford, MA, USA

Roles: Resources, Data curation, Software, Formal analysis

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Suchitta Umashankar

3National Centre for Biological Sciences, GKVK Campus, Bangalore, India

Roles: Validation, Investigation, Methodology

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Nishan Shettigar

3National Centre for Biological Sciences, GKVK Campus, Bangalore, India

Roles: Validation, Investigation, Methodology

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Dasaradhi Palakodeti

1InStem–Institute for Stem Cell Science and Regenerative Medicine, Bangalore, India

Roles: Resources, Data curation

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ORCID record for Dasaradhi Palakodeti

Akash Gulyani

6Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India

Roles: Conceptualization, Supervision, Funding acquisition, Visualization, Writing—original draft, review, and editing

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For correspondence: akash.gulyani@uohyd.ac.in

Arati Ramesh

3National Centre for Biological Sciences, GKVK Campus, Bangalore, India

Roles: Conceptualization, Supervision, Funding acquisition, Visualization, Writing—original draft, review, and editing

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ORCID record for Arati Ramesh
For correspondence: arati@ncbs.res.in

Published 30 September 2021. DOI: 10.26508/lsa.202101213

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RNA sensors for SARS-CoV-2 color and luminescence detection

Anirudh Chakravarthy, Anirudh Nandakumar, Geen George, Shyamsundar Ranganathan, Suchitta Umashankar, Nishan Shettigar, Dasaradhi Palakodeti, Akash Gulyani, Arati Ramesh

Life Science Alliance Sep 2021, 4 (12) e202101213; DOI: 10.26508/lsa.202101213

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RNA sensors for SARS-CoV-2 color and luminescence detection

Anirudh Chakravarthy, Anirudh Nandakumar, Geen George, Shyamsundar Ranganathan, Suchitta Umashankar, Nishan Shettigar, Dasaradhi Palakodeti, Akash Gulyani, Arati Ramesh

Life Science Alliance Sep 2021, 4 (12) e202101213; DOI: 10.26508/lsa.202101213

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