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Research Article
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Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival

View ORCID ProfileSofian Al Shboul  Correspondence email, Olimpia E Curran, Javier A Alfaro, Fiona Lickiss, Erisa Nita, Jacek Kowalski, Faris Naji, Rudolf Nenutil, View ORCID ProfileKathryn L Ball, Radovan Krejcir, View ORCID ProfileBorivoj Vojtesek, Ted R Hupp, View ORCID ProfilePaul M Brennan  Correspondence email
Sofian Al Shboul
1Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK
8Department of Basic Medical Sciences, Faculty of Medicine, The Hashemite University, Zarqa, Jordan
Roles: Conceptualization, Resources, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing
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  • ORCID record for Sofian Al Shboul
  • For correspondence: s.alshboul@ed.ac.uk
Olimpia E Curran
2Department of Neuropathology, Western General Hospital, Edinburgh, UK
3Cardiff University Hospital, Cellular Pathology, Cardiff, UK
Roles: Conceptualization, Data curation, Formal analysis, Supervision, Visualization, Methodology, Writing—original draft
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Javier A Alfaro
1Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK
4International Centre for Cancer Vaccine Science, University of Gdansk, Gdansk, Poland
Roles: Conceptualization, Data curation, Formal analysis, Visualization, Methodology, Writing—original draft
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Fiona Lickiss
4International Centre for Cancer Vaccine Science, University of Gdansk, Gdansk, Poland
Roles: Investigation, Methodology
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Erisa Nita
1Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK
Roles: Conceptualization, Resources, Investigation, Methodology
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Jacek Kowalski
4International Centre for Cancer Vaccine Science, University of Gdansk, Gdansk, Poland
Roles: Formal analysis, Methodology
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Faris Naji
5Pamgene International BV, ’s-Hertogenbosch, Netherlands
Roles: Software, Formal analysis
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Rudolf Nenutil
6Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
Roles: Formal analysis, Funding acquisition, Methodology
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Kathryn L Ball
1Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK
Roles: Conceptualization, Formal analysis, Funding acquisition, Methodology
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  • ORCID record for Kathryn L Ball
Radovan Krejcir
6Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
Roles: Investigation, Methodology
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Borivoj Vojtesek
6Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
Roles: Conceptualization, Funding acquisition, Methodology
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  • ORCID record for Borivoj Vojtesek
Ted R Hupp
1Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK
4International Centre for Cancer Vaccine Science, University of Gdansk, Gdansk, Poland
Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing
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Paul M Brennan
1Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK
7Translational Neurosurgery, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing
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  • ORCID record for Paul M Brennan
  • For correspondence: paul.brennan@ed.ac.uk
Published 13 October 2021. DOI: 10.26508/lsa.202101054
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Article Information

vol. 4 no. 12 e202101054
DOI 
https://doi.org/10.26508/lsa.202101054
PubMed 
34645618

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received February 12, 2021
  • Revision received September 27, 2021
  • Accepted September 27, 2021
  • Published online October 13, 2021.

Copyright & Usage 
© 2021 Al Shboul et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Sofian Al Shboul, Conceptualization, Resources, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing1,8⇑,
  2. Olimpia E Curran, Conceptualization, Data curation, Formal analysis, Supervision, Visualization, Methodology, Writing—original draft2,3,
  3. Javier A Alfaro, Conceptualization, Data curation, Formal analysis, Visualization, Methodology, Writing—original draft1,4,
  4. Fiona Lickiss, Investigation, Methodology4,
  5. Erisa Nita, Conceptualization, Resources, Investigation, Methodology1,
  6. Jacek Kowalski, Formal analysis, Methodology4,
  7. Faris Naji, Software, Formal analysis5,
  8. Rudolf Nenutil, Formal analysis, Funding acquisition, Methodology6,
  9. Kathryn L Ball, Conceptualization, Formal analysis, Funding acquisition, Methodology1,
  10. Radovan Krejcir, Investigation, Methodology6,
  11. Borivoj Vojtesek, Conceptualization, Funding acquisition, Methodology6,
  12. Ted R Hupp, Conceptualization, Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing1,4 and
  13. Paul M Brennan, Conceptualization, Resources, Data curation, Formal analysis, Supervision, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing1,7⇑
  1. 1Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK
  2. 2Department of Neuropathology, Western General Hospital, Edinburgh, UK
  3. 3Cardiff University Hospital, Cellular Pathology, Cardiff, UK
  4. 4International Centre for Cancer Vaccine Science, University of Gdansk, Gdansk, Poland
  5. 5Pamgene International BV, ’s-Hertogenbosch, Netherlands
  6. 6Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
  7. 7Translational Neurosurgery, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
  8. 8Department of Basic Medical Sciences, Faculty of Medicine, The Hashemite University, Zarqa, Jordan
  1. Correspondence: s.alshboul{at}ed.ac.uk
  2. paul.brennan{at}ed.ac.uk
View Full Text

Funding

  • Hashemite University

    Al Shboul S
  • European Regional Development Fund

    No.CZ.02.1.01/0.0/0.0/16_019/0000868
  • Ministry of Health, Czech Republic MH CZ - DRO

    00209805
  • BBSRC

    BB/C511599/1 and BB/J00751X/1
  • The Edinburgh Brain Cancer Development Fund, European Regional Development Fund

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Kinase discovery in GBM using a kinomics platform
Sofian Al Shboul, Olimpia E Curran, Javier A Alfaro, Fiona Lickiss, Erisa Nita, Jacek Kowalski, Faris Naji, Rudolf Nenutil, Kathryn L Ball, Radovan Krejcir, Borivoj Vojtesek, Ted R Hupp, Paul M Brennan
Life Science Alliance Oct 2021, 4 (12) e202101054; DOI: 10.26508/lsa.202101054

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Kinase discovery in GBM using a kinomics platform
Sofian Al Shboul, Olimpia E Curran, Javier A Alfaro, Fiona Lickiss, Erisa Nita, Jacek Kowalski, Faris Naji, Rudolf Nenutil, Kathryn L Ball, Radovan Krejcir, Borivoj Vojtesek, Ted R Hupp, Paul M Brennan
Life Science Alliance Oct 2021, 4 (12) e202101054; DOI: 10.26508/lsa.202101054
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Volume 4, No. 12
December 2021
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