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Research Article
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Functional and metabolic fitness of human CD4+ T lymphocytes during metabolic stress

View ORCID ProfileLisa Holthaus, View ORCID ProfileVirag Sharma, Daniel Brandt, Anette-Gabriele Ziegler, Martin Jastroch, View ORCID ProfileEzio Bonifacio  Correspondence email
Lisa Holthaus
1Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany
2Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany
3German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
Roles: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing
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  • ORCID record for Lisa Holthaus
Virag Sharma
3German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
5Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
6Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the University Hospital and Faculty of Medicine of TU Dresden, Dresden, Germany
Roles: Data curation, Software, Formal analysis, Validation, Investigation, Visualization, Writing—original draft, review, and editing
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  • ORCID record for Virag Sharma
Daniel Brandt
1Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany
Roles: Methodology
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Anette-Gabriele Ziegler
2Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany
3German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
4Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany
Roles: Conceptualization, Resources, Supervision, Funding acquisition, Writing—original draft
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Martin Jastroch
1Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany
7Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Methodology
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Ezio Bonifacio
1Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany
3German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
5Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
6Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the University Hospital and Faculty of Medicine of TU Dresden, Dresden, Germany
Roles: Conceptualization, Resources, Data curation, Supervision, Funding acquisition, Validation, Investigation, Project administration, Writing—original draft, review, and editing
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  • ORCID record for Ezio Bonifacio
  • For correspondence: ezio.bonifacio@tu-dresden.de
Published 27 September 2021. DOI: 10.26508/lsa.202101013
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Article Information

vol. 4 no. 12 e202101013
DOI 
https://doi.org/10.26508/lsa.202101013
PubMed 
34580176

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received January 7, 2021
  • Revision received September 11, 2021
  • Accepted September 13, 2021
  • Published online September 27, 2021.

Copyright & Usage 
© 2021 Holthaus et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Lisa Holthaus, Conceptualization, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing1,2,3,
  2. Virag Sharma, Data curation, Software, Formal analysis, Validation, Investigation, Visualization, Writing—original draft, review, and editing3,5,6,
  3. Daniel Brandt, Methodology1,
  4. Anette-Gabriele Ziegler, Conceptualization, Resources, Supervision, Funding acquisition, Writing—original draft2,3,4,
  5. Martin Jastroch, Conceptualization, Resources, Data curation, Formal analysis, Supervision, Methodology1,7 and
  6. Ezio Bonifacio, Conceptualization, Resources, Data curation, Supervision, Funding acquisition, Validation, Investigation, Project administration, Writing—original draft, review, and editing1,3,5,6⇑
  1. 1Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany
  2. 2Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany
  3. 3German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
  4. 4Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany
  5. 5Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
  6. 6Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the University Hospital and Faculty of Medicine of TU Dresden, Dresden, Germany
  7. 7Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
  1. Correspondence: ezio.bonifacio{at}tu-dresden.de
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Funding

  • JDRF

    17-2012-16 and 17-2012-593
  • German Federal Ministry of Education and Research (BMBF)

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CD4+ T lymphocyte function and metabolism during stress
Lisa Holthaus, Virag Sharma, Daniel Brandt, Anette-Gabriele Ziegler, Martin Jastroch, Ezio Bonifacio
Life Science Alliance Sep 2021, 4 (12) e202101013; DOI: 10.26508/lsa.202101013

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CD4+ T lymphocyte function and metabolism during stress
Lisa Holthaus, Virag Sharma, Daniel Brandt, Anette-Gabriele Ziegler, Martin Jastroch, Ezio Bonifacio
Life Science Alliance Sep 2021, 4 (12) e202101013; DOI: 10.26508/lsa.202101013
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Volume 4, No. 12
December 2021
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