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Research Articles
MKP-1 modulates ubiquitination/phosphorylation of TLR signalingMKP-1 is a dual-specific phosphatase best known to dephosphorylate p38 and JNK. This study shows for the first time that MKP-1 modulates the landscape of ubiquitin ligases (TRAF6) and deubiquitinase enzymes, as well as upstream TLR signaling molecules.
Gradual compaction of the central spindle decreases its dynamicity in PRC1 and EB1 gene-edited cellsAlthough different anaphase proteins bind with characteristically different strength to the central spindle, the overall central spindle dynamicity slows down as mitosis proceeds.
Functional and metabolic fitness of human CD4+ T lymphocytes during metabolic stressHuman T-cell activation, expansion, and effector function is grossly impaired in conditions that combine glucose deprivation and mild mitochondrial stress.
ATAD2 controls chromatin-bound HIRA turnoverParallel study of multiple model systems points to the evolutionary conserved protein ATAD2, as a critical histone chaperone auxiliary factor.
Activation of mitochondrial unfolded protein response protects against multiple exogenous stressorsThis work highlights the importance of the mitochondrial unfolded protein response in allowing organisms to survive external stressors through up-regulation of other stress response pathways.
The DREAM complex represses growth in response to DNA damage in ArabidopsisThis work presents composition, associated proteins, and topological aspects of the DREAM complex in plants and links to the DNA damage response by protein interaction data and mutant analysis.
Engineered RNA biosensors enable ultrasensitive SARS-CoV-2 detection in a simple color and luminescence assayThis work reports engineered toehold RNA–based biosensors for COVID-19 diagnostics, with a simple color or luminescence readout that makes it easily deployable in both well-equipped labs as well as low resource settings.
Gut microbiota–derived short-chain fatty acids protect against the progression of endometriosisThis study revealed that gut-derived n-butyrate protects against endometriosis by activating the expression of RAP1GAP GTPase to inhibit the RAP1 oncogenic pathway, indicating n-butyrate is linked with intestinal microbiota and endometriosis disease.
Loss of Resf1 reduces the efficiency of embryonic stem cell self-renewal and germline entryRESF1 supports ESC self-renewal by raising expression of transmembrane LIF receptor and key pluripotency transcription factors and increases in vitro primordial germ cell differentiation efficiency.
Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repairInhibition of isoprenylcysteine carboxylmethyltransferase reduces cancer cells’ ability to repair DNA damage by suppressing the expression of critical DNA damage repair pathway genes, hence increasing their vulnerability to DNA damaging insults such as PARP inhibitors and other DNA damage agents.
Set4 regulates stress response genes and coordinates histone deacetylases within yeast subtelomeresThe yeast chromatin protein Set4 regulates expression of stress response genes within subtelomeric regions under normal and stress conditions and modulates histone deacetylase activity at chromatin.
Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectorsLegionella pneumophila secretes toxins into the host cell that induce the non-canonical processing and activation of the ER stress sensor and transcription factor ATF6 via a mechanism that is distinct from the canonical pathway activated by unfolded protein buildup.
Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survivalBTK is a dominant bioactive kinase expressed within both cancer and immune cells of GBM tissue. Complex cell co-cultures might better model the impact of kinase inhibitors as therapeutics in GBM.
A brain-specific pgc1α fusion transcript affects gene expression and behavioural outcomes in miceThis study shows that loss of a brain-specific fusion isoform of PGC1a leads to up-regulation of genes and motor impairments in mice, suggesting functional differences between PGC1 isoforms in the brain.
SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heartIn a unique model of fluorescent based mapping of EV recipient cells, RBC-EVs were found to signal to cardiac cells and regulate gene expression in a model of ischemic heart failure.
Resources
OrtSuite: from genomes to prediction of microbial interactions within targeted ecosystem processesOrtSuite predicts synergistic species interactions using the genomic potential of microbial communities
