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Table of Contents

December 2021 | Volume 4, No. 12

Research Articles

  • MKP-1 modulates ubiquitination/phosphorylation of TLR signaling
    Open Access
    MKP-1 modulates ubiquitination/phosphorylation of TLR signaling

    Jaya Talreja, Christian Bauerfeld, Xiantao Wang, Markus Hafner, Yusen Liu, Lobelia Samavati

    Jaya Talreja ... Lobelia Samavati

    Published 27 September 2021

    MKP-1 is a dual-specific phosphatase best known to dephosphorylate p38 and JNK. This study shows for the first time that MKP-1 modulates the landscape of ubiquitin ligases (TRAF6) and deubiquitinase enzymes, as well as upstream TLR signaling molecules.

  • Gradual compaction of the central spindle decreases its dynamicity in PRC1 and EB1 gene-edited cells
    Open Access
    Gradual compaction of the central spindle decreases its dynamicity in PRC1 and EB1 gene-edited cells

    Jayant Asthana, Nicholas I Cade, Davide Normanno, Wei Ming Lim, Thomas Surrey

    Jayant Asthana ... Thomas Surrey

    Published 27 September 2021

    Although different anaphase proteins bind with characteristically different strength to the central spindle, the overall central spindle dynamicity slows down as mitosis proceeds.

  • Functional and metabolic fitness of human CD4<sup>+</sup> T lymphocytes during metabolic stress
    Open Access
    Functional and metabolic fitness of human CD4+ T lymphocytes during metabolic stress

    Lisa Holthaus, Virag Sharma, Daniel Brandt, Anette-Gabriele Ziegler, Martin Jastroch, Ezio Bonifacio

    Lisa Holthaus ... Ezio Bonifacio

    Published 27 September 2021

    Human T-cell activation, expansion, and effector function is grossly impaired in conditions that combine glucose deprivation and mild mitochondrial stress.

  • ATAD2 controls chromatin-bound HIRA turnover
    Open Access
    ATAD2 controls chromatin-bound HIRA turnover

    Tao Wang, Daniel Perazza, Fayçal Boussouar, Matteo Cattaneo, Alexandre Bougdour, Florent Chuffart, Sophie Barral, Alexandra Vargas, Ariadni Liakopoulou, Denis Puthier, Lisa Bargier, Yuichi Morozumi, Mahya Jamshidikia, Isabel Garcia-Saez, Carlo Petosa, Sophie Rousseaux, André Verdel, Saadi Khochbin

    Tao Wang ... Saadi Khochbin

    Published 27 September 2021

    Parallel study of multiple model systems points to the evolutionary conserved protein ATAD2, as a critical histone chaperone auxiliary factor.

  • Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors
    Open Access
    Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors

    Sonja K Soo, Annika Traa, Paige D Rudich, Meeta Mistry, Jeremy M Van Raamsdonk

    Sonja K Soo ... Jeremy M Van Raamsdonk

    Published 28 September 2021

    This work highlights the importance of the mitochondrial unfolded protein response in allowing organisms to survive external stressors through up-regulation of other stress response pathways.

  • The DREAM complex represses growth in response to DNA damage in <em>Arabidopsis</em>
    Open Access
    The DREAM complex represses growth in response to DNA damage in Arabidopsis

    Lucas Lang, Aladár Pettkó-Szandtner, Hasibe Tunçay Elbaşı, Hirotomo Takatsuka, Yuji Nomoto, Ahmad Zaki, Stefan Dorokhov, Geert De Jaeger, Dominique Eeckhout, Masaki Ito, Zoltán Magyar, László Bögre, Maren Heese, Arp Schnittger

    Lucas Lang ... Arp Schnittger

    Published 28 September 2021

    This work presents composition, associated proteins, and topological aspects of the DREAM complex in plants and links to the DNA damage response by protein interaction data and mutant analysis.

  • Engineered RNA biosensors enable ultrasensitive SARS-CoV-2 detection in a simple color and luminescence assay
    Open Access
    Engineered RNA biosensors enable ultrasensitive SARS-CoV-2 detection in a simple color and luminescence assay

    Anirudh Chakravarthy, Anirudh Nandakumar, Geen George, Shyamsundar Ranganathan, Suchitta Umashankar, Nishan Shettigar, Dasaradhi Palakodeti, Akash Gulyani, Arati Ramesh

    Anirudh Chakravarthy ... Arati Ramesh

    Published 30 September 2021

    This work reports engineered toehold RNA–based biosensors for COVID-19 diagnostics, with a simple color or luminescence readout that makes it easily deployable in both well-equipped labs as well as low resource settings.

  • Gut microbiota–derived short-chain fatty acids protect against the progression of endometriosis
    Open Access
    Gut microbiota–derived short-chain fatty acids protect against the progression of endometriosis

    Sangappa B Chadchan, Pooja Popli, Chandrasekhar R Ambati, Eric Tycksen, Sang Jun Han, Serdar E Bulun, Nagireddy Putluri, Scott W Biest, Ramakrishna Kommagani

    Sangappa B Chadchan ... Ramakrishna Kommagani

    Published 30 September 2021

    This study revealed that gut-derived n-butyrate protects against endometriosis by activating the expression of RAP1GAP GTPase to inhibit the RAP1 oncogenic pathway, indicating n-butyrate is linked with intestinal microbiota and endometriosis disease.

  • Loss of <em>Resf1</em> reduces the efficiency of embryonic stem cell self-renewal and germline entry
    Open Access
    Loss of Resf1 reduces the efficiency of embryonic stem cell self-renewal and germline entry

    Matúš Vojtek, Ian Chambers

    Matúš Vojtek ... Ian Chambers

    Published 4 October 2021

    RESF1 supports ESC self-renewal by raising expression of transmembrane LIF receptor and key pluripotency transcription factors and increases in vitro primordial germ cell differentiation efficiency.

  • Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repair
    Open Access
    Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repair

    Jingyi Tang, Patrick J Casey, Mei Wang

    Jingyi Tang ... Mei Wang

    Published 5 October 2021

    Inhibition of isoprenylcysteine carboxylmethyltransferase reduces cancer cells’ ability to repair DNA damage by suppressing the expression of critical DNA damage repair pathway genes, hence increasing their vulnerability to DNA damaging insults such as PARP inhibitors and other DNA damage agents.

  • Set4 regulates stress response genes and coordinates histone deacetylases within yeast subtelomeres
    Open Access
    Set4 regulates stress response genes and coordinates histone deacetylases within yeast subtelomeres

    Yogita Jethmalani, Khoa Tran, Maraki Y Negesse, Winny Sun, Mark Ramos, Deepika Jaiswal, Meagan Jezek, Shandon Amos, Eric Joshua Garcia, DoHwan Park, Erin M Green

    Yogita Jethmalani ... Erin M Green

    Published 8 October 2021

    The yeast chromatin protein Set4 regulates expression of stress response genes within subtelomeric regions under normal and stress conditions and modulates histone deacetylase activity at chromatin.

  • Non-canonical activation of the ER stress sensor ATF6 by <em>Legionella pneumophila</em> effectors
    Open Access
    Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors

    Nnejiuwa U Ibe, Advait Subramanian, Shaeri Mukherjee

    Nnejiuwa U Ibe ... Shaeri Mukherjee

    Published 11 October 2021

    Legionella pneumophila secretes toxins into the host cell that induce the non-canonical processing and activation of the ER stress sensor and transcription factor ATF6 via a mechanism that is distinct from the canonical pathway activated by unfolded protein buildup.

  • Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival
    Open Access
    Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival

    Sofian Al Shboul, Olimpia E Curran, Javier A Alfaro, Fiona Lickiss, Erisa Nita, Jacek Kowalski, Faris Naji, Rudolf Nenutil, Kathryn L Ball, Radovan Krejcir, Borivoj Vojtesek, Ted R Hupp, Paul M Brennan

    Sofian Al Shboul ... Paul M Brennan

    Published 13 October 2021

    BTK is a dominant bioactive kinase expressed within both cancer and immune cells of GBM tissue. Complex cell co-cultures might better model the impact of kinase inhibitors as therapeutics in GBM.

  • A brain-specific <em>pgc1</em>α fusion transcript affects gene expression and behavioural outcomes in mice
    Open Access
    A brain-specific pgc1α fusion transcript affects gene expression and behavioural outcomes in mice

    Oswaldo A Lozoya, Fuhua Xu, Dagoberto Grenet, Tianyuan Wang, Korey D Stevanovic, Jesse D Cushman, Thomas B Hagler, Artiom Gruzdev, Patricia Jensen, Bairon Hernandez, Gonzalo Riadi, Sheryl S Moy, Janine H Santos, Richard P Woychik

    Oswaldo A Lozoya ... Richard P Woychik

    Published 14 October 2021

    This study shows that loss of a brain-specific fusion isoform of PGC1a leads to up-regulation of genes and motor impairments in mice, suggesting functional differences between PGC1 isoforms in the brain.

  • SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart
    Open Access
    SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart

    Nedyalka Valkov, Avash Das, Nathan R Tucker, Guoping Li, Ane M Salvador, Mark D Chaffin, Getulio Pereira De Oliveira Junior, Ivan Kur, Priyanka Gokulnath, Olivia Ziegler, Ashish Yeri, Shulin Lu, Aushee Khamesra, Chunyang Xiao, Rodosthenis Rodosthenous, Srimeenakshi Srinivasan, Vasilis Toxavidis, John Tigges, Louise C Laurent, Stefan Momma, Robert Kitchen, Patrick Ellinor, Ionita Ghiran, Saumya Das

    Nedyalka Valkov ... Saumya Das

    Published 18 October 2021

    In a unique model of fluorescent based mapping of EV recipient cells, RBC-EVs were found to signal to cardiac cells and regulate gene expression in a model of ischemic heart failure.

Resources

  • OrtSuite: from genomes to prediction of microbial interactions within targeted ecosystem processes
    Open Access
    OrtSuite: from genomes to prediction of microbial interactions within targeted ecosystem processes

    João Pedro Saraiva, Alexandre Bartholomäus, René Kallies, Marta Gomes, Marcos Bicalho, Jonas Coelho Kasmanas, Carsten Vogt, Antonis Chatzinotas, Peter Stadler, Oscar Dias, Ulisses Nunes da Rocha

    João Pedro Saraiva ... Ulisses Nunes da Rocha

    Published 27 September 2021

    OrtSuite predicts synergistic species interactions using the genomic potential of microbial communities

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In this Issue

Volume 4, No. 12
December 2021
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