Ccq1–Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres

Shaohua Shi; Yuanze Zhou; Yanjia Lu; Hong Sun; Jing Xue; Zhenfang Wu; Ming Lei

doi:10.26508/lsa.202101106

Research Article

Open Access

Ccq1–Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres

Shaohua Shi, Yuanze Zhou, Yanjia Lu, Hong Sun, Jing Xue, View ORCID ProfileZhenfang Wu Correspondence email, View ORCID ProfileMing Lei Correspondence email

Shaohua Shi

1State Key Laboratory of Oncogenes and Related Genes, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2Shanghai Institute of Precision Medicine, Shanghai, China

Roles: Data curation, Investigation, Methodology

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Yuanze Zhou

4National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China

Roles: Data curation, Methodology

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Yanjia Lu

1State Key Laboratory of Oncogenes and Related Genes, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2Shanghai Institute of Precision Medicine, Shanghai, China

Roles: Data curation, Investigation

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Hong Sun

5State Key Laboratory of Molecular Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China

6School of Life Science and Technology, ShanghaiTech University, Shanghai, China

Roles: Formal analysis

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Jing Xue

5State Key Laboratory of Molecular Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China

Roles: Formal analysis

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Zhenfang Wu

1State Key Laboratory of Oncogenes and Related Genes, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2Shanghai Institute of Precision Medicine, Shanghai, China

Roles: Conceptualization, Data curation, Investigation, Writing—original draft

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ORCID record for Zhenfang Wu
For correspondence: zhenfwu@shsmu.edu.cn

Ming Lei

1State Key Laboratory of Oncogenes and Related Genes, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2Shanghai Institute of Precision Medicine, Shanghai, China

3Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Roles: Conceptualization, Supervision, Funding acquisition, Project administration, Writing—review and editing

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ORCID record for Ming Lei
For correspondence: leim@shsmu.edu.cn

Published 7 September 2021. DOI: 10.26508/lsa.202101106

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Shelterin-mediated telomeric heterochromatin establishment