Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling

Jennifer J Schwarz; Lorenz Grundmann; Thomas Kokot; Kathrin Kläsener; Sandra Fotteler; David Medgyesi; Maja Köhn; Michael Reth; Bettina Warscheid

doi:10.26508/lsa.202101084

Research Article

Open Access

Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling

View ORCID ProfileJennifer J Schwarz, Lorenz Grundmann, View ORCID ProfileThomas Kokot, View ORCID ProfileKathrin Kläsener, Sandra Fotteler, David Medgyesi, View ORCID ProfileMaja Köhn, View ORCID ProfileMichael Reth, View ORCID ProfileBettina Warscheid Correspondence email

Jennifer J Schwarz

1Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, Freiburg, Germany

5Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany

Roles: Data curation, Formal analysis, Validation, Investigation, Visualization, Writing—original draft, review, and editing

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ORCID record for Jennifer J Schwarz

Lorenz Grundmann

1Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, Freiburg, Germany

Roles: Investigation

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Thomas Kokot

2Integrative Signalling Research, Institute of Biology III, Faculty of Biology, University of Freiburg, Freiburg, Germany

4Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany

Roles: Investigation

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ORCID record for Thomas Kokot

Kathrin Kläsener

3Department for Molecular Immunology, Institute of Biology III, Faculty of Biology, University of Freiburg, Freiburg, Germany

4Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany

Roles: Investigation

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ORCID record for Kathrin Kläsener

Sandra Fotteler

1Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, Freiburg, Germany

Roles: Investigation

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David Medgyesi

3Department for Molecular Immunology, Institute of Biology III, Faculty of Biology, University of Freiburg, Freiburg, Germany

Roles: Investigation

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Maja Köhn

2Integrative Signalling Research, Institute of Biology III, Faculty of Biology, University of Freiburg, Freiburg, Germany

4Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany

5Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany

Roles: Resources, Funding acquisition, Writing—review and editing

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ORCID record for Maja Köhn

Michael Reth

3Department for Molecular Immunology, Institute of Biology III, Faculty of Biology, University of Freiburg, Freiburg, Germany

4Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany

5Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany

Roles: Conceptualization, Resources, Funding acquisition, Writing—review and editing

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Bettina Warscheid

1Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, Freiburg, Germany

4Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany

5Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany

Roles: Conceptualization, Resources, Supervision, Funding acquisition, Project administration, Writing—original draft, review, and editing

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ORCID record for Bettina Warscheid
For correspondence: bettina.warscheid@biologie.uni-freiburg.de

Published 15 September 2021. DOI: 10.26508/lsa.202101084

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Study of PTP1B substrates in B cells