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Table of Contents

November 2021 | Volume 4, No. 11

Research Articles

  • Expression of immunoglobulin constant domain genes in neurons of the mouse central nervous system
    Open Access
    Expression of immunoglobulin constant domain genes in neurons of the mouse central nervous system

    Louis Scheurer, Rebecca R Das Gupta, Annika Saebisch, Thomas Grampp, Dietmar Benke, Hanns Ulrich Zeilhofer, Hendrik Wildner

    Louis Scheurer ... Hendrik Wildner

    Published 25 August 2021

    In this study, Scheurer et al demonstrate that two genes encoding the effector domain of immunoglobulins are not only expressed by lymphocytes of the immune system but also by neurons in the central nervous system.

  • Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene <em>STAG2</em>
    Open Access
    Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2

    Melanie L Bailey, David Tieu, Andrea Habsid, Amy Hin Yan Tong, Katherine Chan, Jason Moffat, Philip Hieter

    Melanie L Bailey ... Philip Hieter

    Published 30 August 2021

    The context-dependency of genetic interactions of the cohesin gene STAG2, specifically STAG1 and the iron regulatory gene IREB2, are revealed by CRISPR-Cas9 screening in three different cellular backgrounds.

  • Statistical guidelines for quality control of next-generation sequencing techniques
    Open Access
    Statistical guidelines for quality control of next-generation sequencing techniques

    Maximilian Sprang, Matteo Krüger, Miguel A Andrade-Navarro, Jean-Fred Fontaine

    Maximilian Sprang ... Jean-Fred Fontaine

    Published 30 August 2021

    Condition-specific statistical guidelines and accurate classification trees for quality control of functional genomics NGS files (RNA-seq, ChIP-seq and DNase-seq) have been generated using thousands of reference files from the ENCODE project and made available to the community.

  • High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo
    Open Access
    High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo

    Nina A Bonekamp, Min Jiang, Elisa Motori, Rodolfo Garcia Villegas, Camilla Koolmeister, Ilian Atanassov, Andrea Mesaros, Chan Bae Park, Nils-Göran Larsson

    Nina A Bonekamp ... Nils-Göran Larsson

    Published 30 August 2021

    The TFAM-to-mtDNA ratio is critically important and must be maintained within a physiological range to allow normal mtDNA expression and prevent nucleoid hypercompaction in different mouse tissues.

  • Biallelic <em>ADPRHL2</em> mutations in complex neuropathy affect ADP ribosylation and DNA damage response
    Open Access
    Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response

    Danique Beijer, Thomas Agnew, Johannes Gregor Matthias Rack, Evgeniia Prokhorova, Tine Deconinck, Berten Ceulemans, Stojan Peric, Vedrana Milic Rasic, Peter De Jonghe, Ivan Ahel, Jonathan Baets

    Danique Beijer ... Jonathan Baets

    Published 3 September 2021

    This work studies known and new ADPRHL2 mutations with different disease mechanisms overall indicating that loss of nuclear ARH3 alone is pathogenic via dysregulated nuclear ADP ribosylation.

  • Ccq1–Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres
    Open Access
    Ccq1–Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres

    Shaohua Shi, Yuanze Zhou, Yanjia Lu, Hong Sun, Jing Xue, Zhenfang Wu, Ming Lei

    Shaohua Shi ... Ming Lei

    Published 7 September 2021

    This study unveils a role of Ccq1–Raf2 interaction in CLRC recruitment to establish heterochromatin at telomeres, providing a positive feedback mechanism between shelterin and CLRC for subtelomeric heterochromatin assembly.

  • Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19
    Open Access
    Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19

    Claudia Gomes, Marisol Zuniga, Kelly A Crotty, Kun Qian, Nubia Catalina Tovar, Lawrence Hsu Lin, Kimon V Argyropoulos, Robert Clancy, Peter Izmirly, Jill Buyon, David C Lee, Maria Fernanda Yasnot-Acosta, Huilin Li, Paolo Cotzia, Ana Rodriguez

    Claudia Gomes ... Ana Rodriguez

    Published 9 September 2021

    COVID-19 induces high levels of autoimmune anti-DNA and anti-phosphatidylserine antibodies that are detected in some patients upon hospital admission and predict later development of severe disease.

  • Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling
    Open Access
    Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling

    Jennifer J Schwarz, Lorenz Grundmann, Thomas Kokot, Kathrin Kläsener, Sandra Fotteler, David Medgyesi, Maja Köhn, Michael Reth, Bettina Warscheid

    Jennifer J Schwarz ... Bettina Warscheid

    Published 15 September 2021

    This study analyses the function of the protein tyrosine phosphatase 1B identifying its binding partners and dephosphorylation targets for modulating B cell antigen receptor signaling.

  • The Th1 cell regulatory circuitry is largely conserved between human and mouse
    Open Access
    The Th1 cell regulatory circuitry is largely conserved between human and mouse

    Stephen Henderson, Venu Pullabhatla, Arnulf Hertweck, Emanuele de Rinaldis, Javier Herrero, Graham M Lord, Richard G Jenner

    Stephen Henderson ... Richard G Jenner

    Published 16 September 2021

    Comparison of the binding sites of the Th1 lineage-specifying transcription factor T-bet between human and mouse reveals differences in binding sites but that the most of the target genes are shared.

  • An extended DNA-free intranuclear compartment organizes centrosome microtubules in malaria parasites
    Open Access
    An extended DNA-free intranuclear compartment organizes centrosome microtubules in malaria parasites

    Caroline S Simon, Charlotta Funaya, Johanna Bauer, Yannik Voβ, Marta Machado, Alexander Penning, Darius Klaschka, Marek Cyrklaff, Juyeop Kim, Markus Ganter, Julien Guizetti

    Caroline S Simon ... Julien Guizetti

    Published 17 September 2021

    Malaria arises during the proliferation of Plasmodium spp. in human blood, whereas the underlying atypical cell division mechanisms remain poorly understood. This study uses advanced imaging to dissect dynamics and organization of the centrosome, a key division regulator.

  • Choroid plexus APP regulates adult brain proliferation and animal behavior
    Open Access
    Choroid plexus APP regulates adult brain proliferation and animal behavior

    Karen Arnaud, Vanessa Oliveira Moreira, Jean Vincent, Glenn Dallerac, Chantal Dubreuil, Edmond Dupont, Max Richter, Ulrike C Müller, Laure Rondi-Reig, Alain Prochiantz, Ariel A Di Nardo

    Karen Arnaud ... Ariel A Di Nardo

    Published 20 September 2021

    Adult mouse choroid plexus shows elevated APP expression. sAPPα secreted into the CSF modulates neurogenic niche proliferation, whereas choroid plexus expression of fAD APP mutants leads to reduced niche proliferation, deficits in hippocampus synaptic plasticity, and learning defects.

  • Elevated glycolysis imparts functional ability to CD8<sup>+</sup> T cells in HIV infection
    Open Access
    Elevated glycolysis imparts functional ability to CD8+ T cells in HIV infection

    AKM Nur-ur Rahman, Jun Liu, Shariq Mujib, Segen Kidane, Arman Ali, Steven Szep, Carrie Han, Phil Bonner, Michael Parsons, Erika Benko, Colin Kovacs, Feng Yun Yue, Mario Ostrowski

    AKM Nur-ur Rahman ... Mario Ostrowski

    Published 21 September 2021

    Cytotoxic killer CD8+ T cells (CTLs) are central effectors that eliminate virus infected cells. In HIV infection, HIV-specific CTLs become functionally impaired. Herein we investigated the link between metabolism and CD8+ T-cell functional impairment, known as exhaustion.

  • Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in mice
    Open Access
    Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in mice

    Theresa Rauschendorfer, Selina Gurri, Irina Heggli, Luigi Maddaluno, Michael Meyer, Álvaro Inglés-Prieto, Harald Janovjak, Sabine Werner

    Theresa Rauschendorfer ... Sabine Werner

    Published 21 September 2021

    Optogenetic activation of FGFR2 allowed temporally precise induction of signaling and behavioural changes, but counter-regulation at multiple levels prevented a sustained response in keratinocytes.

  • INPP5K and Atlastin-1 maintain the nonuniform distribution of ER–plasma membrane contacts in neurons
    Open Access
    INPP5K and Atlastin-1 maintain the nonuniform distribution of ER–plasma membrane contacts in neurons

    Jingbo Sun, Raihanah Harion, Tomoki Naito, Yasunori Saheki

    Jingbo Sun ... Yasunori Saheki

    Published 23 September 2021

    CIL-1 and ATLN-1 maintain the balance between ER tubules and sheets and prevent invasion of cortical ER sheets into the axon, contributing to the non-uniform distribution of neuronal ER-PM contacts.

  • SATB1-dependent mitochondrial ROS production controls TCR signaling in CD4 T cells
    Open Access
    SATB1-dependent mitochondrial ROS production controls TCR signaling in CD4 T cells

    Taku Kuwabara, Fumio Ishikawa, Masataka Ikeda, Tomomi Ide, Terumi Kohwi-Shigematsu, Yuriko Tanaka, Motonari Kondo

    Taku Kuwabara ... Motonari Kondo

    Published 28 September 2021

    SATB1 regulates mitochondrial function and reactive oxygen species (ROS) production through the expression of mitochondrial transcription factor A. SATB1-mediated ROS production is necessary for TCR stimulation and T-cell function.

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Volume 4, No. 11
November 2021
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