RNA sequencing reveals niche gene expression effects of beta-hydroxybutyrate in primary myotubes

Philip MM Ruppert; Lei Deng; Guido JEJ Hooiveld; Roland WJ Hangelbroek; Anja Zeigerer; Sander Kersten

doi:10.26508/lsa.202101037

Research Article

Open Access

RNA sequencing reveals niche gene expression effects of beta-hydroxybutyrate in primary myotubes

View ORCID ProfilePhilip MM Ruppert, Lei Deng, View ORCID ProfileGuido JEJ Hooiveld, Roland WJ Hangelbroek, View ORCID ProfileAnja Zeigerer, View ORCID ProfileSander Kersten Correspondence email

Philip MM Ruppert

1Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands

Roles: Conceptualization, Formal analysis, Validation, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing

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ORCID record for Philip MM Ruppert

Lei Deng

1Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands

Roles: Conceptualization, Resources, Formal analysis, Investigation, Visualization, Methodology, Writing—review and editing

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Guido JEJ Hooiveld

1Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands

Roles: Resources, Data curation, Formal analysis, Visualization, Writing—review and editing

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ORCID record for Guido JEJ Hooiveld

Roland WJ Hangelbroek

1Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands

2Euretos BV, Utrecht, The Netherlands

Roles: Resources, Data curation, Formal analysis, Visualization, Writing—review and editing

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Anja Zeigerer

3Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany and Joint Heidelberg-Institute for Diabetes and Cancer Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany

4German Center for Diabetes Research (DZD), Neuherberg, Germany

Roles: Resources, Methodology, Writing—review and editing

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Sander Kersten

1Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands

Roles: Conceptualization, Resources, Formal analysis, Supervision, Funding acquisition, Validation, Project administration, Writing—review and editing

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ORCID record for Sander Kersten
For correspondence: sander.kersten@wur.nl

Published 18 August 2021. DOI: 10.26508/lsa.202101037

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β-hydroxybutyrate minimally affects gene expression