Article Figures & Data
Figures
- Figure 1. The mechanism of replication of SARS-CoV-2 in the human cell.
- Figure 2. SARS-CoV-2 viral genome and host-dependent metabolic pathways.
- Figure 3. PPi-pathway intersection node—Nsp9.
(A) Methionine degradation. (B) Methionine salvage cycle. (C) Cysteine biosynthesis.
- Figure 4. PPi-pathway intersection node—Nsp8.
- Figure 5. PPi-pathway intersection node—Nsp2.
(A) Fatty acid oxidation. (B) Stearate biosynthesis. (C) Vitamin D3 biosynthesis.
- Figure 6. PPi-pathway intersection node—Nsp4.
- Figure 7. Pi-pathway intersection nodes - Nsp7 and Orf8a in carbohydrate and fatty acid metabolism.
(A) PPi-pathway intersection node—Nsp7. (B) PPi-Pathway intersection node—Orf8a. (C) PPi-pathway intersection node—Nsp7 and Orf8a.
- Figure 8. Development of an integrated model of the Human Airway Epithelial cell and SARS-CoV-2.
Tables
Class Pathway Sub-pathway Human gene Sars gene Macrophage Epithelial cell Biosynthesis Amino acids L-selenocysteine biosynthesis SEPSECS Nsp8 Y N Biosynthesis Amino acids Cysteine, and methionine MAT2B Nsp9 Y Y Biosynthesis Fatty acids Fatty acid and long fatty acid biosynthesis SLC27A2 Nsp2 Y Y Biosynthesis Fatty acids Fatty acid and long fatty acid biosynthesis ACSL3 Nsp7 Y N Biosynthesis Fatty acids Stearate biosynthesis SLC27A2 Nsp2 Y Y Biosynthesis Fatty acids Stearate biosynthesis ACSL3 Nsp7 Y Y Biosynthesis Carbohydrate biosynthesis Glycan and oligosaccharide biosynthesis ALG11 Nsp4 Y Y Biosynthesis Carbohydrate biosynthesis Glycan HS2ST1 Orf8a Y Y Biosynthesis Carbohydrate biosynthesis Glycan MOGS Nsp7 Y Y Biosynthesis Carbohydrate biosynthesis Glycan and oligosaccharide biosynthesis ALG5 ORF3a Y Y Biosynthesis Carbohydrate biosynthesis Glycan, oligosaccharide, and glycosaminoglycan biosynthesis CHPF ORF8a Y Y Biosynthesis Carbohydrate biosynthesis Glycan, oligosaccharide, and glycosaminoglycan biosynthesis HS6ST2 ORF8a Y Y Biosynthesis Cofactors Vitamin D3 biosynthesis POR Nsp2 Y Y Biosynthesis Cofactors Vitamin K epoxide cycle GGCX Main protease N Y Biosynthesis Hormones C20 prostanoid biosynthesis PTGES2 Nsp7 Y Y Biosynthesis tRNA charging tRNA charging TARS2 Main protease Y Y Degradation Amino acids L-lysine degradation AASS Main protease N Y Degradation Amino acids L-tryptophan degradation POR Nsp2 Y Y Degradation Amino acids L-methionine degradation MAT2B Main protease Y Y Degradation Fatty acids Ceramide and sphingolipid recycling SLC27A2 Nsp2 Y Y Degradation Fatty acids Ceramide and sphingolipid recycling POR Nsp2 Y Y Degradation Fatty acids Ceramide and sphingolipid recycling ACSL3 Nsp7 Y Y Degradation Fatty acids Phospholipases PLD3 ORF8a Y Y Degradation Amine degradation Dopamine degradation COMT Nsp7 Y Y Degradation Hormones Heme HMOX1 ORF3a Y Y Degradation Hormones melatonin POR Nsp2 Y Y Degradation Hormones Adrenalin COMT Nsp2 Y Y Degradation Hormones L-dopa degradation COMT Nsp2 Y Y
Supplemental Data 1.
MEMOTE results of the integrated human airway epithelial model and SARS-CoV-2 (iHsaEC21_SARS-CoV-2).[LSA-2020-00954_Supplemental_Data_1.zip]
Supplemental Data 2.
MEMOTE results of the integrated macrophage model (iAB_AMO1410_SARS-CoV-2) and SARS-CoV-2.[LSA-2020-00954_Supplemental_Data_2.zip]
Supplemental Data 3.
MEMOTE results of the draft human airway epithelial model by Wang et al (2012).[LSA-2020-00954_Supplemental_Data_3.zip]
Integrated human/SARS-CoV-2 metabolic model
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