Research Article
Open Access
Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids
Maarten H Geurts, Eyleen de Poel, Cayetano Pleguezuelos-Manzano, View ORCID ProfileRurika Oka, View ORCID ProfileLéo Carrillo, Amanda Andersson-Rolf, Matteo Boretto, Jesse E Brunsveld, Ruben van Boxtel, Jeffrey M Beekman, View ORCID ProfileHans Clevers Correspondence email
Maarten H Geurts
1Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands
2Oncode Institute, Hubrecht Institute, Utrecht, the Netherlands
Roles: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing
Eyleen de Poel
3Department of Pediatric Respiratory Medicine, Wilhelmina Children’s Hospital, University Medical Center, Utrecht University, Utrecht, the Netherlands
4Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, the Netherlands
Roles: Data curation, Formal analysis, Validation, Investigation, Visualization, Writing—review and editing
Cayetano Pleguezuelos-Manzano
1Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands
2Oncode Institute, Hubrecht Institute, Utrecht, the Netherlands
Roles: Formal analysis, Investigation, Methodology, Writing—review and editing
Rurika Oka
5Oncode Institute,Princes Maxima Center, Utrecht, The Netherlands
Roles: Software, Visualization, Writing—review and editing
Léo Carrillo
1Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands
2Oncode Institute, Hubrecht Institute, Utrecht, the Netherlands
Roles: Validation, Investigation, Methodology, Writing—review and editing
Amanda Andersson-Rolf
1Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands
2Oncode Institute, Hubrecht Institute, Utrecht, the Netherlands
Roles: Supervision, Methodology, Writing—review and editing
Matteo Boretto
1Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands
2Oncode Institute, Hubrecht Institute, Utrecht, the Netherlands
Roles: Investigation, Methodology, Writing—review and editing
Jesse E Brunsveld
3Department of Pediatric Respiratory Medicine, Wilhelmina Children’s Hospital, University Medical Center, Utrecht University, Utrecht, the Netherlands
4Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, the Netherlands
Roles: Software, Visualization
Ruben van Boxtel
5Oncode Institute,Princes Maxima Center, Utrecht, The Netherlands
Roles: Software, Supervision, Writing—review and editing
Jeffrey M Beekman
3Department of Pediatric Respiratory Medicine, Wilhelmina Children’s Hospital, University Medical Center, Utrecht University, Utrecht, the Netherlands
4Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, the Netherlands
Roles: Supervision, Writing—review and editing
Hans Clevers
1Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands
2Oncode Institute, Hubrecht Institute, Utrecht, the Netherlands
Roles: Conceptualization, Supervision, Funding acquisition, Writing—original draft, review, and editing
Published 9 August 2021. DOI: 10.26508/lsa.202000940
Prime editing for cancer modeling and functional CFTR repair
Maarten H Geurts, Eyleen de Poel, Cayetano Pleguezuelos-Manzano, Rurika Oka, Léo Carrillo, Amanda Andersson-Rolf, Matteo Boretto, Jesse E Brunsveld, Ruben van Boxtel, Jeffrey M Beekman, Hans Clevers
Life Science Alliance Aug 2021, 4 (10) e202000940; DOI: 10.26508/lsa.202000940
Prime editing for cancer modeling and functional CFTR repair
Maarten H Geurts, Eyleen de Poel, Cayetano Pleguezuelos-Manzano, Rurika Oka, Léo Carrillo, Amanda Andersson-Rolf, Matteo Boretto, Jesse E Brunsveld, Ruben van Boxtel, Jeffrey M Beekman, Hans Clevers
Life Science Alliance Aug 2021, 4 (10) e202000940; DOI: 10.26508/lsa.202000940
In this Issue
Volume 4, No. 10
October 2021
Advertisement
Jump to section
Related Articles
- No related articles found.