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Table of Contents

October 2021 | Volume 4, No. 10

Research Articles

  • Incomplete antiviral treatment may induce longer durations of viral shedding during SARS-CoV-2 infection
    Open Access
    Incomplete antiviral treatment may induce longer durations of viral shedding during SARS-CoV-2 infection

    Kwang Su Kim, Shoya Iwanami, Takafumi Oda, Yasuhisa Fujita, Keiji Kuba, Taiga Miyazaki, Keisuke Ejima, Shingo Iwami

    Kwang Su Kim ... Shingo Iwami

    Published 3 August 2021

    Treatments initiated early, such as 0.5 d after virus inoculation, with intermediate to relatively high efficacy (30–70% inhibition of virus replication) yield a prolonged duration of viral shedding (by about 6.0 d) compared with no treatment.

  • Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19
    Open Access
    Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19

    Bridget P Bannerman, Jorge Júlvez, Alexandru Oarga, Tom L Blundell, Pablo Moreno, R Andres Floto

    Bridget P Bannerman ... R Andres Floto

    Published 5 August 2021

    Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19 and provide insights into viral entry inhibition, immune regulation, and drug optimisation strategies.

  • Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells
    Open Access
    Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells

    Jennifer L Vella, Aleksey Molodtsov, Christina V Angeles, Bruce R Branchini, Mary Jo Turk, Yina H Huang

    Jennifer L Vella ... Yina H Huang

    Published 6 August 2021

    Tissue-resident memory (TRM) T cells in mouse and human melanoma-associated vitiligo skin form large lymphoid aggregates with CXCL16-expressing dendritic cells. CD11c depletion or disruption of the CXCR6-CXCL16 axis results in loss of skin TRM cells and tumor immunity.

  • Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids
    Open Access
    Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids

    Maarten H Geurts, Eyleen de Poel, Cayetano Pleguezuelos-Manzano, Rurika Oka, Léo Carrillo, Amanda Andersson-Rolf, Matteo Boretto, Jesse E Brunsveld, Ruben van Boxtel, Jeffrey M Beekman, Hans Clevers

    Maarten H Geurts ... Hans Clevers

    Published 9 August 2021

    Here, the authors evaluate prime editing in human adult stem cell–derived organoids. TP53 mutations are modeled in hepatocyte and colon organoids and the clinical application of prime editing is evaluated by repairing mutations in CFTR without genome-wide off-targets.

  • Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroids
    Open Access
    Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroids

    Jimpi Langthasa, Purba Sarkar, Shruthi Narayanan, Rahul Bhagat, Annapurna Vadaparty, Ramray Bhat

    Jimpi Langthasa ... Ramray Bhat

    Published 10 August 2021

    Expression dynamics of basement membrane-like extracellular matrix and fibronectin regulate transitions between solid (moruloid) and cavitational (blastuloid) phenotypes of ovarian cancer spheroids.

  • Tyrosine phosphorylation of lamin A by Src promotes disassembly of nuclear lamina in interphase
    Open Access
    Tyrosine phosphorylation of lamin A by Src promotes disassembly of nuclear lamina in interphase

    Ching-Tung Chu, Yi-Hsuan Chen, Wen-Tai Chiu, Hong-Chen Chen

    Ching-Tung Chu ... Hong-Chen Chen

    Published 12 August 2021

    Phosphorylation of lamin A at tyrosine residue 45 by Src has an adverse effect on the assembly of nuclear lamina, which may be involved in nuclear dysmorphia, genomic instability, and nuclear plasticity in interphase.

  • Dystrophin involvement in peripheral circadian SRF signalling
    Open Access
    Dystrophin involvement in peripheral circadian SRF signalling

    Corinne A Betts, Aarti Jagannath, Tirsa LE van Westering, Melissa Bowerman, Subhashis Banerjee, Jinhong Meng, Maria Sofia Falzarano, Lara Cravo, Graham McClorey, Katharina E Meijboom, Amarjit Bhomra, Wooi Fang Lim, Carlo Rinaldi, John R Counsell, Katarzyna Chwalenia, Elizabeth O’Donovan, Amer F Saleh, Michael J Gait, Jennifer E Morgan, Alessandra Ferlini, Russell G Foster, Matthew JA Wood

    Corinne A Betts ... Matthew JA Wood

    Published 13 August 2021

    Absence of integral sarcolemmal protein, dystrophin, disrupts the RhoA-actin-SRF cascade in skeletal muscle, with subsequent dysregulation of downstream-SRF circadian targets and circadian rhythm.

  • AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation
    Open Access
    AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation

    Daehee Hwang, Miju Kim, Soyeon Kim, Mi Ra Kwon, Ye-Seul Kang, Dahyun Kim, Ho-Chul Kang, Dae-Sik Lim

    Daehee Hwang ... Dae-Sik Lim

    Published 17 August 2021

    This work reveals a novel function of WWP1 E3 ligase in the mono-ubiquitination of AMOTL2, which enables the binding and activation of LATS kinases upon contact inhibition.

  • RNA sequencing reveals niche gene expression effects of beta-hydroxybutyrate in primary myotubes
    Open Access
    RNA sequencing reveals niche gene expression effects of beta-hydroxybutyrate in primary myotubes

    Philip MM Ruppert, Lei Deng, Guido JEJ Hooiveld, Roland WJ Hangelbroek, Anja Zeigerer, Sander Kersten

    Philip MM Ruppert ... Sander Kersten

    Published 18 August 2021

    RNA sequencing reveals primary myocyte-specific gene-regulatory niche effects for β-hydroxybutyrate but do not support a general signaling of β-hydroxybutyrate role in other primary cells or during cellular differentiation in vitro.

  • Improved systemic AAV gene therapy with a neurotrophic capsid in Niemann–Pick disease type C1 mice
    Open Access
    Improved systemic AAV gene therapy with a neurotrophic capsid in Niemann–Pick disease type C1 mice

    Cristin D Davidson, Alana L Gibson, Tansy Gu, Laura L Baxter, Benjamin E Deverman, Keith Beadle, Arturo A Incao, Jorge L Rodriguez-Gil, Hideji Fujiwara, Xuntian Jiang, Randy J Chandler, Daniel S Ory, Viviana Gradinaru, Charles P Venditti, William J Pavan

    Cristin D Davidson ... William J Pavan

    Published 18 August 2021

    This work highlights the importance of CNS transduction for treatment of neurological diseases, a finding with significant clinical implications considering the long-lasting effects of gene therapy.

  • The structure and flexibility analysis of the <em>Arabidopsis</em> synaptotagmin 1 reveal the basis of its regulation at membrane contact sites
    Open Access
    The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites

    Juan L Benavente, Dritan Siliqi, Lourdes Infantes, Laura Lagartera, Alberto Mills, Federico Gago, Noemí Ruiz-López, Miguel A Botella, María J Sánchez-Barrena, Armando Albert

    Juan L Benavente ... Armando Albert

    Published 18 August 2021

    Plant SYT1 transports lipids between endoplasmic reticulum and plasma membrane in response to stress. The protein flexibility and lipid-binding specificity determine SYT1 function at molecular level.

  • A role for Rad5 in ribonucleoside monophosphate (rNMP) tolerance
    Open Access
    A role for Rad5 in ribonucleoside monophosphate (rNMP) tolerance

    Menattallah Elserafy, Iman El-Shiekh, Dalia Fleifel, Reham Atteya, Abdelrahman AlOkda, Mohamed M Abdrabbou, Mostafa Nasr, Sherif F El-Khamisy

    Menattallah Elserafy ... Sherif F El-Khamisy

    Published 18 August 2021

    Ribonucleoside incorporation in genomic DNA poses a significant threat to genomic integrity. Here, we describe how cells tolerate this threat and discuss implications for cancer therapeutics.

  • Elevated glucose increases genomic instability by inhibiting nucleotide excision repair
    Open Access
    Elevated glucose increases genomic instability by inhibiting nucleotide excision repair

    Alexandra K Ciminera, Sarah C Shuck, John Termini

    Alexandra K Ciminera ... John Termini

    Published 23 August 2021

    Exposure to chronic, elevated glucose inhibits nucleotide excision repair, which leads to accumulation of DNA glycation adducts, increased DNA strand breaks, and activation of the DNA damage response.

  • Serum proteomics reveals disorder of lipoprotein metabolism in sepsis
    Open Access
    Serum proteomics reveals disorder of lipoprotein metabolism in sepsis

    Xi Liang, Tianzhou Wu, Qi Chen, Jing Jiang, Yongpo Jiang, Yanyun Ruan, Huaping Zhang, Sheng Zhang, Chao Zhang, Peng Chen, Yuhang Lv, Jiaojiao Xin, Dongyan Shi, Xin Chen, Jun Li, Yinghe Xu

    Xi Liang ... Yinghe Xu

    Published 24 August 2021

    This study illustrated that lipoprotein and lipid metabolism might play a significant role in patients with sepsis and that complement activation was significantly enriched in patients with sepsis-associated encephalopathy.

  • Glucocorticoid signaling induces transcriptional memory and universally reversible chromatin changes
    Open Access
    Glucocorticoid signaling induces transcriptional memory and universally reversible chromatin changes

    Melissa Bothe, René Buschow, Sebastiaan H Meijsing

    Melissa Bothe ... Sebastiaan H Meijsing

    Published 26 August 2021

    Glucocorticoids are stress hormones that elicit various cellular responses. These responses are typically reversible; however, in some instances, a previous exposure is “remembered” and influences the response to a subsequent hormone encounter.

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Volume 4, No. 10
October 2021
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