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Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers

View ORCID ProfileJoseph A Newman, Angeline E Gavard, Simone Lieb, Madhwesh C Ravichandran, Katja Hauer, Patrick Werni, Leonhard Geist, View ORCID ProfileJark Böttcher, View ORCID ProfileJohn R Engen, Klaus Rumpel, Matthias Samwer, View ORCID ProfileMark Petronczki, View ORCID ProfileOpher Gileadi  Correspondence email
Joseph A Newman
1Structural Genomics Consortium, University of Oxford, Oxford, UK
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Angeline E Gavard
1Structural Genomics Consortium, University of Oxford, Oxford, UK
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Simone Lieb
2Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
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Madhwesh C Ravichandran
2Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
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Katja Hauer
2Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
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Patrick Werni
2Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
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Leonhard Geist
2Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
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Jark Böttcher
2Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
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John R Engen
3Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA
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Klaus Rumpel
2Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
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Matthias Samwer
2Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
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Mark Petronczki
2Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
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Opher Gileadi
1Structural Genomics Consortium, University of Oxford, Oxford, UK
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  • ORCID record for Opher Gileadi
  • For correspondence: opher.gileadi@cmd.ox.ac.uk
Published 16 November 2020. DOI: 10.26508/lsa.202000795
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Crystal structure of Werner syndrome helicase core domain
Joseph A Newman, Angeline E Gavard, Simone Lieb, Madhwesh C Ravichandran, Katja Hauer, Patrick Werni, Leonhard Geist, Jark Böttcher, John R Engen, Klaus Rumpel, Matthias Samwer, Mark Petronczki, Opher Gileadi
Life Science Alliance Nov 2020, 4 (1) e202000795; DOI: 10.26508/lsa.202000795

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Crystal structure of Werner syndrome helicase core domain
Joseph A Newman, Angeline E Gavard, Simone Lieb, Madhwesh C Ravichandran, Katja Hauer, Patrick Werni, Leonhard Geist, Jark Böttcher, John R Engen, Klaus Rumpel, Matthias Samwer, Mark Petronczki, Opher Gileadi
Life Science Alliance Nov 2020, 4 (1) e202000795; DOI: 10.26508/lsa.202000795
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Volume 4, No. 1
January 2021
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