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Table of Contents

January 2021 | Volume 4, No. 1

Research Articles

  • Myeloid transformation by <em>MLL</em>-<em>ENL</em> depends strictly on C/EBP
    Open Access
    Myeloid transformation by MLL-ENL depends strictly on C/EBP

    Radoslaw Wesolowski, Elisabeth Kowenz-Leutz, Karin Zimmermann, Dorothea Dörr, Maria Hofstätter, Robert K Slany, Alexander Mildner, Achim Leutz

    Radoslaw Wesolowski ... Achim Leutz

    Published 3 November 2020

    This publication shows that C/EBP (CCAAT enhancer–binding protein) transcription factors are mandatory for maintaining the myeloid leukemic phenotype, suggesting a therapeutic option by interfering with the non-oncogenic C/EBP dependence.

  • Interferon lambda 4 can directly activate human CD19<sup>+</sup> B cells and CD8<sup>+</sup> T cells
    Open Access
    Interferon lambda 4 can directly activate human CD19+ B cells and CD8+ T cells

    Mairene Coto-Llerena, Marco Lepore, Julian Spagnuolo, Daniela Di Blasi, Diego Calabrese, Aleksei Suslov, Glenn Bantug, Francois HT Duong, Luigi M Terracciano, Gennaro De Libero, Markus H Heim

    Mairene Coto-Llerena ... Markus H Heim

    Published 6 November 2020

    Direct effects of IFNλ4 on CD8+ T cells can link the IFNλ4 genotype to differential clearance of hepatitis C virus infections.

  • The actin regulator profilin 1 is functionally associated with the mammalian centrosome
    Open Access
    The actin regulator profilin 1 is functionally associated with the mammalian centrosome

    Michaela Nejedlá, Anastasiya Klebanovych, Vadym Sulimenko, Tetyana Sulimenko, Eduarda Dráberová, Pavel Dráber, Roger Karlsson

    Michaela Nejedlá ... Roger Karlsson

    Published 12 November 2020

    The actin regulator profilin 1 recently shown to control microtubule elongation at the cell periphery is found to interact with the γ-tubulin ring complex and tune centrosomal microtubule nucleation.

  • Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers
    Open Access
    Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers

    Joseph A Newman, Angeline E Gavard, Simone Lieb, Madhwesh C Ravichandran, Katja Hauer, Patrick Werni, Leonhard Geist, Jark Böttcher, John R Engen, Klaus Rumpel, Matthias Samwer, Mark Petronczki, Opher Gileadi

    Joseph A Newman ... Opher Gileadi

    Published 16 November 2020

    WRN is a key drug target for cancers with microsatellite instability. A crystal structure of the helicase domain of WRN identifies its unique features and provides a basis for structure-guided design of inhibitors.

  • Characterization of ori and parS-like functions in secondary genome replicons in <em>Deinococcus radiodurans</em>
    Open Access
    Characterization of ori and parS-like functions in secondary genome replicons in Deinococcus radiodurans

    Ganesh K Maurya, Hari S Misra

    Ganesh K Maurya ... Hari S Misra

    Published 16 November 2020

    An array of direct repeats upstream to parAB operon helps in secondary genome elements’ maintenance independent of primary chromosome in multipartite genome harboring bacterium Deinococcus radiodurans.

  • G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation
    Open Access
    G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation

    Weiqiang Jing, Xing Guo, Fei Qin, Yue Li, Ganyu Wang, Yuxuan Bi, Xing Jin, Lihui Han, Xiaoyuan Dong, Yunxue Zhao

    Weiqiang Jing ... Yunxue Zhao

    Published 24 November 2020

    Granulocyte colony-stimulating factor suppresses erythropoiesis of bone marrow and promotes splenic erythropoiesis during lipopolysaccharide-induced systemic inflammation in mice.

  • Short-duration splice promoting compound enables a tunable mouse model of spinal muscular atrophy
    Open Access
    Short-duration splice promoting compound enables a tunable mouse model of spinal muscular atrophy

    Anne Rietz, Kevin J Hodgetts, Hrvoje Lusic, Kevin M Quist, Erkan Y Osman, Christian L Lorson, Elliot J Androphy

    Anne Rietz ... Elliot J Androphy

    Published 24 November 2020

    We describe drug treatment paradigms that allow investigation of cellular and molecular pathogenesis at different stages of spinal muscular atrophy in a mouse model.

  • Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network
    Open Access
    Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network

    Hadrien Delattre, Kalesh Sasidharan, Orkun S Soyer

    Hadrien Delattre ... Orkun S Soyer

    Published 24 November 2020

    Using genomic and structural information from SARS-CoV-2, we created a biomass function capturing its amino and nucleic acid requirements and incorporated this into a metabolic model of the human lung cell to predict metabolic perturbations that inhibit virus reproduction.

  • BRD2 regulation of sigma-2 receptor upon cholesterol deprivation
    Open Access
    BRD2 regulation of sigma-2 receptor upon cholesterol deprivation

    Hongtao Shen, Jing Li, Xiujie Xie, Huan Yang, Mengxue Zhang, Bowen Wang, K Craig Kent, Jorge Plutzky, Lian-Wang Guo

    Hongtao Shen ... Lian-Wang Guo

    Published 24 November 2020

    Upon cholesterol deprivation, epigenetic bookmark reader BRD2 and master transcription factor SREBP2 form a complex at bookmarked chromatin (H3K27ac), thereby activating the transcription of the sigma-2 receptor—a recently unveiled player in cholesterol homeostasis.

  • Wnt10b-GSK3β–dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells
    Open Access
    Wnt10b-GSK3β–dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells

    Yu-Chih Lin, Alexander Haas, Anja Bufe, Sabnam Parbin, Magdalena Hennecke, Oksana Voloshanenko, Julia Gross, Michael Boutros, Sergio P Acebron, Holger Bastians

    Yu-Chih Lin ... Holger Bastians

    Published 30 November 2020

    Autocrine Wnt10b signaling ensures proper mitotic microtubule polymerization and faithful chromosome segregation.

  • Scratch-induced partial skin wounds re-epithelialize by sheets of independently migrating keratinocytes
    Open Access
    Scratch-induced partial skin wounds re-epithelialize by sheets of independently migrating keratinocytes

    Laura Bornes, Reinhard Windoffer, Rudolf E Leube, Jessica Morgner, Jacco van Rheenen

    Laura Bornes ... Jacco van Rheenen

    Published 30 November 2020

    Intravital microscopy of scratch wounds in the murine skin reveals that individual basal keratinocytes migrate in a swarming fashion towards the wound to bypass intact hair follicles, thereby facilitating fast repair.

  • Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies
    Open Access
    Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies

    Merav Cohen, Amir Giladi, Catarina Raposo, Mor Zada, Baoguo Li, Julia Ruckh, Aleksandra Deczkowska, Boaz Mohar, Ravid Shechter, Rachel G Lichtenstein, Ido Amit, Michal Schwartz

    Merav Cohen ... Michal Schwartz

    Published 4 December 2020

    We found that acute insult to the central nervous system induces the formation of lymphocyte aggregates reminiscent of tertiary lymphoid structures within the spinal cord meninges. Unlike draining CNS-cervical lymph nodes, meningeal lymphocytes are locally activated during neuro-inflammtion and neurodegeneration.

Resources

  • Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice
    Open Access
    Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice

    Ruth Karlina, Dominik Lutter, Viktorian Miok, David Fischer, Irem Altun, Theresa Schöttl, Kenji Schorpp, Andreas Israel, Cheryl Cero, James W Johnson, Ingrid Kapser-Fischer, Anika Böttcher, Susanne Keipert, Annette Feuchtinger, Elisabeth Graf, Tim Strom, Axel Walch, Heiko Lickert, Thomas Walzthoeni, Matthias Heinig, Fabian J Theis, Cristina García-Cáceres, Aaron M Cypess, Siegfried Ussar

    Ruth Karlina ... Siegfried Ussar

    Published 30 November 2020

    Using a number of cell biological and statistical methods we identify and characterize EIF5, TCF25 and BIN1 as markers for individual brown adipocyte subtypes in C57BL/6J mice.

  • Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome
    Open Access
    Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome

    Katerina Boufea, Victor Gonzalez-Huici, Marcus Lindberg, Nelly N Olova, Stefan Symeonides, Olga Oikonomidou, Nizar N Batada

    Katerina Boufea ... Nizar N Batada

    Published 2 December 2020

    Single-cell sequencing of γδ-T cells from human blood and tumours revealed novel markers of subtypes with distinct effector functions and a subtype that is associated with favourable clinical outcome.

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Volume 4, No. 1
January 2021
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