Research Article


Open Access
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
Dorothea Bestle, Miriam Ruth Heindl, Hannah Limburg, View ORCID ProfileThuy Van Lam van, Oliver Pilgram, Hong Moulton, View ORCID ProfileDavid A Stein, Kornelia Hardes, Markus Eickmann, View ORCID ProfileOlga Dolnik, Cornelius Rohde, Hans-Dieter Klenk, Wolfgang Garten, Torsten Steinmetzer, View ORCID ProfileEva Böttcher-Friebertshäuser Correspondence email
Dorothea Bestle
1Institute of Virology, Philipps-University, Marburg, Germany
Miriam Ruth Heindl
1Institute of Virology, Philipps-University, Marburg, Germany
Hannah Limburg
1Institute of Virology, Philipps-University, Marburg, Germany
Thuy Van Lam van
2Institute of Pharmaceutical Chemistry, Philipps-University, Marburg, Germany
Oliver Pilgram
2Institute of Pharmaceutical Chemistry, Philipps-University, Marburg, Germany
Hong Moulton
3Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA
David A Stein
3Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA
Kornelia Hardes
2Institute of Pharmaceutical Chemistry, Philipps-University, Marburg, Germany
4Fraunhofer Institute for Molecular Biology and Applied Ecology, Gießen, Germany
Markus Eickmann
1Institute of Virology, Philipps-University, Marburg, Germany
5German Center for Infection Research (DZIF), Marburg-Gießen-Langen Site, Emerging Infections Unit, Philipps-University, Marburg, Germany
Olga Dolnik
1Institute of Virology, Philipps-University, Marburg, Germany
5German Center for Infection Research (DZIF), Marburg-Gießen-Langen Site, Emerging Infections Unit, Philipps-University, Marburg, Germany
Cornelius Rohde
1Institute of Virology, Philipps-University, Marburg, Germany
5German Center for Infection Research (DZIF), Marburg-Gießen-Langen Site, Emerging Infections Unit, Philipps-University, Marburg, Germany
Hans-Dieter Klenk
1Institute of Virology, Philipps-University, Marburg, Germany
Wolfgang Garten
1Institute of Virology, Philipps-University, Marburg, Germany
Torsten Steinmetzer
2Institute of Pharmaceutical Chemistry, Philipps-University, Marburg, Germany
Eva Böttcher-Friebertshäuser
1Institute of Virology, Philipps-University, Marburg, Germany
Published 23 July 2020. DOI: 10.26508/lsa.202000786
TMPRSS2 and furin activate SARS-CoV-2
Dorothea Bestle, Miriam Ruth Heindl, Hannah Limburg, Thuy Van Lam van, Oliver Pilgram, Hong Moulton, David A Stein, Kornelia Hardes, Markus Eickmann, Olga Dolnik, Cornelius Rohde, Hans-Dieter Klenk, Wolfgang Garten, Torsten Steinmetzer, Eva Böttcher-Friebertshäuser
Life Science Alliance Jul 2020, 3 (9) e202000786; DOI: 10.26508/lsa.202000786
TMPRSS2 and furin activate SARS-CoV-2
Dorothea Bestle, Miriam Ruth Heindl, Hannah Limburg, Thuy Van Lam van, Oliver Pilgram, Hong Moulton, David A Stein, Kornelia Hardes, Markus Eickmann, Olga Dolnik, Cornelius Rohde, Hans-Dieter Klenk, Wolfgang Garten, Torsten Steinmetzer, Eva Böttcher-Friebertshäuser
Life Science Alliance Jul 2020, 3 (9) e202000786; DOI: 10.26508/lsa.202000786
In this Issue
Volume 3, No. 9
September 2020
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