TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

Dorothea Bestle; Miriam Ruth Heindl; Hannah Limburg; Thuy Van Lam van; Oliver Pilgram; Hong Moulton; David A Stein; Kornelia Hardes; Markus Eickmann; Olga Dolnik; Cornelius Rohde; Hans-Dieter Klenk; Wolfgang Garten; Torsten Steinmetzer; Eva Böttcher-Friebertshäuser

doi:10.26508/lsa.202000786

Research Article

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TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

Dorothea Bestle, Miriam Ruth Heindl, Hannah Limburg, View ORCID ProfileThuy Van Lam van, Oliver Pilgram, Hong Moulton, View ORCID ProfileDavid A Stein, Kornelia Hardes, Markus Eickmann, View ORCID ProfileOlga Dolnik, Cornelius Rohde, Hans-Dieter Klenk, Wolfgang Garten, Torsten Steinmetzer, View ORCID ProfileEva Böttcher-Friebertshäuser Correspondence email

Dorothea Bestle

1Institute of Virology, Philipps-University, Marburg, Germany

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Miriam Ruth Heindl

1Institute of Virology, Philipps-University, Marburg, Germany

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Hannah Limburg

1Institute of Virology, Philipps-University, Marburg, Germany

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Thuy Van Lam van

2Institute of Pharmaceutical Chemistry, Philipps-University, Marburg, Germany

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Oliver Pilgram

2Institute of Pharmaceutical Chemistry, Philipps-University, Marburg, Germany

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Hong Moulton

3Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA

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David A Stein

3Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA

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Kornelia Hardes

2Institute of Pharmaceutical Chemistry, Philipps-University, Marburg, Germany

4Fraunhofer Institute for Molecular Biology and Applied Ecology, Gießen, Germany

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Markus Eickmann

1Institute of Virology, Philipps-University, Marburg, Germany

5German Center for Infection Research (DZIF), Marburg-Gießen-Langen Site, Emerging Infections Unit, Philipps-University, Marburg, Germany

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Olga Dolnik

1Institute of Virology, Philipps-University, Marburg, Germany

5German Center for Infection Research (DZIF), Marburg-Gießen-Langen Site, Emerging Infections Unit, Philipps-University, Marburg, Germany

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Cornelius Rohde

1Institute of Virology, Philipps-University, Marburg, Germany

5German Center for Infection Research (DZIF), Marburg-Gießen-Langen Site, Emerging Infections Unit, Philipps-University, Marburg, Germany

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Hans-Dieter Klenk

1Institute of Virology, Philipps-University, Marburg, Germany

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Wolfgang Garten

1Institute of Virology, Philipps-University, Marburg, Germany

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Torsten Steinmetzer

2Institute of Pharmaceutical Chemistry, Philipps-University, Marburg, Germany

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Eva Böttcher-Friebertshäuser

1Institute of Virology, Philipps-University, Marburg, Germany

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For correspondence: friebertshaeuser@staff.uni-marburg.de

Published 23 July 2020. DOI: 10.26508/lsa.202000786

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TMPRSS2 and furin activate SARS-CoV-2

Dorothea Bestle, Miriam Ruth Heindl, Hannah Limburg, Thuy Van Lam van, Oliver Pilgram, Hong Moulton, David A Stein, Kornelia Hardes, Markus Eickmann, Olga Dolnik, Cornelius Rohde, Hans-Dieter Klenk, Wolfgang Garten, Torsten Steinmetzer, Eva Böttcher-Friebertshäuser

Life Science Alliance Jul 2020, 3 (9) e202000786; DOI: 10.26508/lsa.202000786