Research Article
Open Access
BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes
Hyoung Kyu Kim, Tae Hee Ko, In-Sung Song, Yu Jeong Jeong, Hye Jin Heo, Seung Hun Jeong, Min Kim, Nam Mi Park, View ORCID ProfileDae Yun Seo, Pham Trong Kha, Sun-Woo Kim, Sung Ryul Lee, Sung Woo Cho, Jong Chul Won, Jae Boum Youm, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Kyoung Im Cho, Ippei Shimizu, Tohru Minamino, Nam-Chul Ha, Young Shik Park, Bernd Nilius, View ORCID ProfileJin Han Correspondence email
Hyoung Kyu Kim
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Tae Hee Ko
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
In-Sung Song
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Yu Jeong Jeong
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Hye Jin Heo
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Seung Hun Jeong
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Min Kim
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Nam Mi Park
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Dae Yun Seo
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Pham Trong Kha
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Sun-Woo Kim
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Sung Ryul Lee
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Sung Woo Cho
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
2Division of Cardiology, Department of Internal Medicine, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea
Jong Chul Won
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Jae Boum Youm
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Kyung Soo Ko
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Byoung Doo Rhee
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Nari Kim
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Kyoung Im Cho
3Division of Cardiology, Department of Internal Medicine, College of Medicine, Kosin University, Busan, Republic of Korea
Ippei Shimizu
4Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Tohru Minamino
4Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Nam-Chul Ha
5Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea
Young Shik Park
6School of Biotechnology and Biomedical Science, Inje University, Kimhae, Republic of Korea
Bernd Nilius
7Katholieke Universiteit Leuven, Department of Cellular and Molecular Medicine, Leuven, Belgium
Jin Han
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
Published 22 July 2020. DOI: 10.26508/lsa.201900619
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BH4 attenuates cardiomyopathy via CaMKK2
Hyoung Kyu Kim, Tae Hee Ko, In-Sung Song, Yu Jeong Jeong, Hye Jin Heo, Seung Hun Jeong, Min Kim, Nam Mi Park, Dae Yun Seo, Pham Trong Kha, Sun-Woo Kim, Sung Ryul Lee, Sung Woo Cho, Jong Chul Won, Jae Boum Youm, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Kyoung Im Cho, Ippei Shimizu, Tohru Minamino, Nam-Chul Ha, Young Shik Park, Bernd Nilius, Jin Han
Life Science Alliance Jul 2020, 3 (9) e201900619; DOI: 10.26508/lsa.201900619
BH4 attenuates cardiomyopathy via CaMKK2
Hyoung Kyu Kim, Tae Hee Ko, In-Sung Song, Yu Jeong Jeong, Hye Jin Heo, Seung Hun Jeong, Min Kim, Nam Mi Park, Dae Yun Seo, Pham Trong Kha, Sun-Woo Kim, Sung Ryul Lee, Sung Woo Cho, Jong Chul Won, Jae Boum Youm, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Kyoung Im Cho, Ippei Shimizu, Tohru Minamino, Nam-Chul Ha, Young Shik Park, Bernd Nilius, Jin Han
Life Science Alliance Jul 2020, 3 (9) e201900619; DOI: 10.26508/lsa.201900619
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Volume 3, No. 9
September 2020
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