BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes

Hyoung Kyu Kim; Tae Hee Ko; In-Sung Song; Yu Jeong Jeong; Hye Jin Heo; Seung Hun Jeong; Min Kim; Nam Mi Park; Dae Yun Seo; Pham Trong Kha; Sun-Woo Kim; Sung Ryul Lee; Sung Woo Cho; Jong Chul Won; Jae Boum Youm; Kyung Soo Ko; Byoung Doo Rhee; Nari Kim; Kyoung Im Cho; Ippei Shimizu; Tohru Minamino; Nam-Chul Ha; Young Shik Park; Bernd Nilius; Jin Han

doi:10.26508/lsa.201900619

Research Article

Open Access

BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes

Hyoung Kyu Kim, Tae Hee Ko, In-Sung Song, Yu Jeong Jeong, Hye Jin Heo, Seung Hun Jeong, Min Kim, Nam Mi Park, View ORCID ProfileDae Yun Seo, Pham Trong Kha, Sun-Woo Kim, Sung Ryul Lee, Sung Woo Cho, Jong Chul Won, Jae Boum Youm, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Kyoung Im Cho, Ippei Shimizu, Tohru Minamino, Nam-Chul Ha, Young Shik Park, Bernd Nilius, View ORCID ProfileJin Han Correspondence email

Hyoung Kyu Kim

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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Tae Hee Ko

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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In-Sung Song

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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Yu Jeong Jeong

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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Hye Jin Heo

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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Seung Hun Jeong

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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Min Kim

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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Nam Mi Park

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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Dae Yun Seo

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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ORCID record for Dae Yun Seo

Pham Trong Kha

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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Sun-Woo Kim

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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Sung Ryul Lee

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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Sung Woo Cho

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

2Division of Cardiology, Department of Internal Medicine, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea

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Jong Chul Won

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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Jae Boum Youm

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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Kyung Soo Ko

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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Byoung Doo Rhee

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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Nari Kim

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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Kyoung Im Cho

3Division of Cardiology, Department of Internal Medicine, College of Medicine, Kosin University, Busan, Republic of Korea

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Ippei Shimizu

4Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

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Tohru Minamino

4Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

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Nam-Chul Ha

5Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea

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Young Shik Park

6School of Biotechnology and Biomedical Science, Inje University, Kimhae, Republic of Korea

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Bernd Nilius

7Katholieke Universiteit Leuven, Department of Cellular and Molecular Medicine, Leuven, Belgium

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Jin Han

1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea

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ORCID record for Jin Han
For correspondence: phyhanj@inje.ac.kr

Published 22 July 2020. DOI: 10.26508/lsa.201900619

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BH4 attenuates cardiomyopathy via CaMKK2

Hyoung Kyu Kim, Tae Hee Ko, In-Sung Song, Yu Jeong Jeong, Hye Jin Heo, Seung Hun Jeong, Min Kim, Nam Mi Park, Dae Yun Seo, Pham Trong Kha, Sun-Woo Kim, Sung Ryul Lee, Sung Woo Cho, Jong Chul Won, Jae Boum Youm, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Kyoung Im Cho, Ippei Shimizu, Tohru Minamino, Nam-Chul Ha, Young Shik Park, Bernd Nilius, Jin Han

Life Science Alliance Jul 2020, 3 (9) e201900619; DOI: 10.26508/lsa.201900619