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BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes

Hyoung Kyu Kim, Tae Hee Ko, In-Sung Song, Yu Jeong Jeong, Hye Jin Heo, Seung Hun Jeong, Min Kim, Nam Mi Park, View ORCID ProfileDae Yun Seo, Pham Trong Kha, Sun-Woo Kim, Sung Ryul Lee, Sung Woo Cho, Jong Chul Won, Jae Boum Youm, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Kyoung Im Cho, Ippei Shimizu, Tohru Minamino, Nam-Chul Ha, Young Shik Park, Bernd Nilius, View ORCID ProfileJin Han  Correspondence email
Hyoung Kyu Kim
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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Tae Hee Ko
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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In-Sung Song
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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Yu Jeong Jeong
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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Hye Jin Heo
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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Seung Hun Jeong
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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Min Kim
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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Nam Mi Park
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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Dae Yun Seo
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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  • ORCID record for Dae Yun Seo
Pham Trong Kha
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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Sun-Woo Kim
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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Sung Ryul Lee
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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Sung Woo Cho
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
2Division of Cardiology, Department of Internal Medicine, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea
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Jong Chul Won
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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Jae Boum Youm
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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Kyung Soo Ko
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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Byoung Doo Rhee
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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Nari Kim
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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Kyoung Im Cho
3Division of Cardiology, Department of Internal Medicine, College of Medicine, Kosin University, Busan, Republic of Korea
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Ippei Shimizu
4Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
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Tohru Minamino
4Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
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Nam-Chul Ha
5Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea
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Young Shik Park
6School of Biotechnology and Biomedical Science, Inje University, Kimhae, Republic of Korea
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Bernd Nilius
7Katholieke Universiteit Leuven, Department of Cellular and Molecular Medicine, Leuven, Belgium
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Jin Han
1Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
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  • ORCID record for Jin Han
  • For correspondence: phyhanj@inje.ac.kr
Published 22 July 2020. DOI: 10.26508/lsa.201900619
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BH4 attenuates cardiomyopathy via CaMKK2
Hyoung Kyu Kim, Tae Hee Ko, In-Sung Song, Yu Jeong Jeong, Hye Jin Heo, Seung Hun Jeong, Min Kim, Nam Mi Park, Dae Yun Seo, Pham Trong Kha, Sun-Woo Kim, Sung Ryul Lee, Sung Woo Cho, Jong Chul Won, Jae Boum Youm, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Kyoung Im Cho, Ippei Shimizu, Tohru Minamino, Nam-Chul Ha, Young Shik Park, Bernd Nilius, Jin Han
Life Science Alliance Jul 2020, 3 (9) e201900619; DOI: 10.26508/lsa.201900619

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BH4 attenuates cardiomyopathy via CaMKK2
Hyoung Kyu Kim, Tae Hee Ko, In-Sung Song, Yu Jeong Jeong, Hye Jin Heo, Seung Hun Jeong, Min Kim, Nam Mi Park, Dae Yun Seo, Pham Trong Kha, Sun-Woo Kim, Sung Ryul Lee, Sung Woo Cho, Jong Chul Won, Jae Boum Youm, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Kyoung Im Cho, Ippei Shimizu, Tohru Minamino, Nam-Chul Ha, Young Shik Park, Bernd Nilius, Jin Han
Life Science Alliance Jul 2020, 3 (9) e201900619; DOI: 10.26508/lsa.201900619
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Volume 3, No. 9
September 2020
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