About the Cover
Research Articles
Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathwayDeletion of the polycystins activates components of the centrosomal integrity pathway, resulting in delayed cell deciliation and prolonged activation of cilia-related signaling pathways.
Attenuation of cGAS/STING activity during mitosisTo limit deleterious interferon responses with each cell division and open mitosis, cGAS/STING activities are shown to be dampened-with Golgi vesiculation preventing activation of STING.
A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cellsThe paralogous COPI coat subunit γ1-COP plays a unique role in promoting neurite outgrowth during the neuronal differentiation of mouse pluripotent cells.
BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetesThis study reports that BH4 activates CaMKK2/PGC-1α; signaling pathway and has a therapeutic effect on diabetic cardiomyopathy.
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cellsThe spike protein S of SARS-CoV-2 is activated by TMPRSS2 and furin. Inhibition of either one of these proteases can render the S protein unable to mediate virus entry and, therefore, provides a promising approach for COVID-19 treatment.
Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1high memory phenotype CD4 T cellsPD-1high memory CD4 T cells are pathogenic in autoimmune disease; here they show their expression of Egr2 is defective in rheumatoid arthritis and Egr2 & 3 control their inflammation and homeostasis.
An evolutionary approach to systematic discovery of novel deubiquitinases, applied to LegionellaThe analysis of the relationships between different deubiquitinase classes leads to the definition of an aromatic “gatekeeper” motif that distinguishes DUBs from other cysteine proteases and helps to predict new bacterial DUBs.
CYP20-3 deglutathionylates 2-CysPRX A and suppresses peroxide detoxification during heat stressPosttranslational modification by a reduced glutathione determines distinctive quaternary structures and functions between two 2-cysteine peroxiredoxin A and B in the chloroplasts.
A time-resolved interaction analysis of Bem1 reconstructs the flow of Cdc42 during polar growthA temporal dissection correlates changes in composition and architecture of the interaction network of Bem1 with changes in cellular morphology and the activities of its binding partners.
Mitochondrial spongiotic brain disease: astrocytic stress and harmful rapamycin and ketosis effectAstrocyte-specific mtDNA depletion causes spongiotic encephalopathy, aggravated by ketogenic diet or rapamycin. Astrocytes, but not neurons, drive mitochondrial integrated stress response in the CNS.
