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Table of Contents

September 2020 | Volume 3, No. 9

Research Articles

  • Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway
    Open Access
    Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway

    Vasileios Gerakopoulos, Peter Ngo, Leonidas Tsiokas

    Vasileios Gerakopoulos ... Leonidas Tsiokas

    Published 10 July 2020

    Deletion of the polycystins activates components of the centrosomal integrity pathway, resulting in delayed cell deciliation and prolonged activation of cilia-related signaling pathways.

  • Attenuation of cGAS/STING activity during mitosis
    Open Access
    Attenuation of cGAS/STING activity during mitosis

    Brittany L Uhlorn, Eduardo R Gamez, Shuaizhi Li, Samuel K Campos

    Brittany L Uhlorn ... Samuel K Campos

    Published 13 July 2020

    To limit deleterious interferon responses with each cell division and open mitosis, cGAS/STING activities are shown to be dampened-with Golgi vesiculation preventing activation of STING.

  • A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells
    Open Access
    A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells

    Manu Jain Goyal, Xiyan Zhao, Mariya Bozhinova, Karla Andrade-López, Cecilia de Heus, Sandra Schulze-Dramac, Michaela Müller-McNicoll, Judith Klumperman, Julien Béthune

    Manu Jain Goyal ... Julien Béthune

    Published 14 July 2020

    The paralogous COPI coat subunit γ1-COP plays a unique role in promoting neurite outgrowth during the neuronal differentiation of mouse pluripotent cells.

  • BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes
    Open Access
    BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes

    Hyoung Kyu Kim, Tae Hee Ko, In-Sung Song, Yu Jeong Jeong, Hye Jin Heo, Seung Hun Jeong, Min Kim, Nam Mi Park, Dae Yun Seo, Pham Trong Kha, Sun-Woo Kim, Sung Ryul Lee, Sung Woo Cho, Jong Chul Won, Jae Boum Youm, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Kyoung Im Cho, Ippei Shimizu, Tohru Minamino, Nam-Chul Ha, Young Shik Park, Bernd Nilius, Jin Han

    Hyoung Kyu Kim ... Jin Han

    Published 22 July 2020

    This study reports that BH4 activates CaMKK2/PGC-1α; signaling pathway and has a therapeutic effect on diabetic cardiomyopathy.

  • TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
    Open Access
    TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

    Dorothea Bestle, Miriam Ruth Heindl, Hannah Limburg, Thuy Van Lam van, Oliver Pilgram, Hong Moulton, David A Stein, Kornelia Hardes, Markus Eickmann, Olga Dolnik, Cornelius Rohde, Hans-Dieter Klenk, Wolfgang Garten, Torsten Steinmetzer, Eva Böttcher-Friebertshäuser

    Dorothea Bestle ... Eva Böttcher-Friebertshäuser

    Published 23 July 2020

    The spike protein S of SARS-CoV-2 is activated by TMPRSS2 and furin. Inhibition of either one of these proteases can render the S protein unable to mediate virus entry and, therefore, provides a promising approach for COVID-19 treatment.

  • Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1<sup>high</sup> memory phenotype CD4 T cells
    Open Access
    Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1high memory phenotype CD4 T cells

    Alistair LJ Symonds, Wei Zheng, Tizong Miao, Haiyu Wang, TieShang Wang, Ruth Kiome, Xiujuan Hou, Suling Li, Ping Wang

    Alistair LJ Symonds ... Ping Wang

    Published 24 July 2020

    PD-1high memory CD4 T cells are pathogenic in autoimmune disease; here they show their expression of Egr2 is defective in rheumatoid arthritis and Egr2 & 3 control their inflammation and homeostasis.

  • An evolutionary approach to systematic discovery of novel deubiquitinases, applied to <em>Legionella</em>
    Open Access
    An evolutionary approach to systematic discovery of novel deubiquitinases, applied to Legionella

    Thomas Hermanns, Ilka Woiwode, Ricardo FM Guerreiro, Robert Vogt, Michael Lammers, Kay Hofmann

    Thomas Hermanns ... Kay Hofmann

    Published 27 July 2020

    The analysis of the relationships between different deubiquitinase classes leads to the definition of an aromatic “gatekeeper” motif that distinguishes DUBs from other cysteine proteases and helps to predict new bacterial DUBs.

  • CYP20-3 deglutathionylates 2-CysPRX A and suppresses peroxide detoxification during heat stress
    Open Access
    CYP20-3 deglutathionylates 2-CysPRX A and suppresses peroxide detoxification during heat stress

    Wenshan Liu, Izailda Barbosa dos Santos, Anna Moye, Sang-Wook Park

    Wenshan Liu ... Sang-Wook Park

    Published 30 July 2020

    Posttranslational modification by a reduced glutathione determines distinctive quaternary structures and functions between two 2-cysteine peroxiredoxin A and B in the chloroplasts.

  • A time-resolved interaction analysis of Bem1 reconstructs the flow of Cdc42 during polar growth
    Open Access
    A time-resolved interaction analysis of Bem1 reconstructs the flow of Cdc42 during polar growth

    Sören Grinhagens, Alexander Dünkler, Yehui Wu, Lucia Rieger, Philipp Brenner, Thomas Gronemeyer, Medhanie A Mulaw, Nils Johnsson

    Sören Grinhagens ... Nils Johnsson

    Published 31 July 2020

    A temporal dissection correlates changes in composition and architecture of the interaction network of Bem1 with changes in cellular morphology and the activities of its binding partners.

  • Mitochondrial spongiotic brain disease: astrocytic stress and harmful rapamycin and ketosis effect
    Open Access
    Mitochondrial spongiotic brain disease: astrocytic stress and harmful rapamycin and ketosis effect

    Olesia Ignatenko, Joni Nikkanen, Alexander Kononov, Nicola Zamboni, Gulayse Ince-Dunn, Anu Suomalainen

    Olesia Ignatenko ... Anu Suomalainen

    Published 31 July 2020

    Astrocyte-specific mtDNA depletion causes spongiotic encephalopathy, aggravated by ketogenic diet or rapamycin. Astrocytes, but not neurons, drive mitochondrial integrated stress response in the CNS.

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Volume 3, No. 9
September 2020
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