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USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

View ORCID ProfileEmma V Rusilowicz-Jones, View ORCID ProfileJane Jardine, View ORCID ProfileAndreas Kallinos, Adan Pinto-Fernandez, View ORCID ProfileFranziska Guenther, Mariacarmela Giurrandino, View ORCID ProfileFrancesco G Barone, Katy McCarron, Christopher J Burke, Alejandro Murad, View ORCID ProfileAitor Martinez, Elena Marcassa, Malte Gersch, Alexandre J Buckmelter, Katherine J Kayser-Bricker, Frederic Lamoliatte, Akshada Gajbhiye, View ORCID ProfileSimon Davis, Hannah C Scott, Emma Murphy, Katherine England, View ORCID ProfileHeather Mortiboys, David Komander, Matthias Trost, Benedikt M Kessler, Stephanos Ioannidis, Michael K Ahlijanian, View ORCID ProfileSylvie Urbé  Correspondence email, View ORCID ProfileMichael J Clague  Correspondence email
Emma V Rusilowicz-Jones
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
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  • ORCID record for Emma V Rusilowicz-Jones
Jane Jardine
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
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  • ORCID record for Jane Jardine
Andreas Kallinos
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
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  • ORCID record for Andreas Kallinos
Adan Pinto-Fernandez
2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
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Franziska Guenther
3Alzheimer’s Research UK, Oxford Drug Discovery Institute, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
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  • ORCID record for Franziska Guenther
Mariacarmela Giurrandino
3Alzheimer’s Research UK, Oxford Drug Discovery Institute, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
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Francesco G Barone
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
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  • ORCID record for Francesco G Barone
Katy McCarron
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
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Christopher J Burke
4FORMA Therapeutics, Watertown, MA, USA
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Alejandro Murad
4FORMA Therapeutics, Watertown, MA, USA
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Aitor Martinez
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
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  • ORCID record for Aitor Martinez
Elena Marcassa
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
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Malte Gersch
5Chemical Genomics Centre, Max-Planck-Institute of Molecular Physiology, Dortmund, Germany
6Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Dortmund, Germany
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Alexandre J Buckmelter
4FORMA Therapeutics, Watertown, MA, USA
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Katherine J Kayser-Bricker
4FORMA Therapeutics, Watertown, MA, USA
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Frederic Lamoliatte
10Laboratory for Biological Mass Spectrometry, Newcastle University Biosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle, UK
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Akshada Gajbhiye
10Laboratory for Biological Mass Spectrometry, Newcastle University Biosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle, UK
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Simon Davis
2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
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  • ORCID record for Simon Davis
Hannah C Scott
2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
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Emma Murphy
3Alzheimer’s Research UK, Oxford Drug Discovery Institute, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
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Katherine England
3Alzheimer’s Research UK, Oxford Drug Discovery Institute, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
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Heather Mortiboys
7Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK
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  • ORCID record for Heather Mortiboys
David Komander
8Ubiquitin Signalling Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Medical Biology, University of Melbourne, Melbourne, Australia
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Matthias Trost
10Laboratory for Biological Mass Spectrometry, Newcastle University Biosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle, UK
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Benedikt M Kessler
2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
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Stephanos Ioannidis
4FORMA Therapeutics, Watertown, MA, USA
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Michael K Ahlijanian
4FORMA Therapeutics, Watertown, MA, USA
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Sylvie Urbé
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
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  • ORCID record for Sylvie Urbé
  • For correspondence: urbe@liv.ac.uk
Michael J Clague
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
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  • ORCID record for Michael J Clague
  • For correspondence: clague@liv.ac.uk
Published 7 July 2020. DOI: 10.26508/lsa.202000768
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USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation
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USP30 sets a mitophagy trigger
Emma V Rusilowicz-Jones, Jane Jardine, Andreas Kallinos, Adan Pinto-Fernandez, Franziska Guenther, Mariacarmela Giurrandino, Francesco G Barone, Katy McCarron, Christopher J Burke, Alejandro Murad, Aitor Martinez, Elena Marcassa, Malte Gersch, Alexandre J Buckmelter, Katherine J Kayser-Bricker, Frederic Lamoliatte, Akshada Gajbhiye, Simon Davis, Hannah C Scott, Emma Murphy, Katherine England, Heather Mortiboys, David Komander, Matthias Trost, Benedikt M Kessler, Stephanos Ioannidis, Michael K Ahlijanian, Sylvie Urbé, Michael J Clague
Life Science Alliance Jul 2020, 3 (8) e202000768; DOI: 10.26508/lsa.202000768

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USP30 sets a mitophagy trigger
Emma V Rusilowicz-Jones, Jane Jardine, Andreas Kallinos, Adan Pinto-Fernandez, Franziska Guenther, Mariacarmela Giurrandino, Francesco G Barone, Katy McCarron, Christopher J Burke, Alejandro Murad, Aitor Martinez, Elena Marcassa, Malte Gersch, Alexandre J Buckmelter, Katherine J Kayser-Bricker, Frederic Lamoliatte, Akshada Gajbhiye, Simon Davis, Hannah C Scott, Emma Murphy, Katherine England, Heather Mortiboys, David Komander, Matthias Trost, Benedikt M Kessler, Stephanos Ioannidis, Michael K Ahlijanian, Sylvie Urbé, Michael J Clague
Life Science Alliance Jul 2020, 3 (8) e202000768; DOI: 10.26508/lsa.202000768
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Volume 3, No. 8
August 2020
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