USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

Emma V Rusilowicz-Jones; Jane Jardine; Andreas Kallinos; Adan Pinto-Fernandez; Franziska Guenther; Mariacarmela Giurrandino; Francesco G Barone; Katy McCarron; Christopher J Burke; Alejandro Murad; Aitor Martinez; Elena Marcassa; Malte Gersch; Alexandre J Buckmelter; Katherine J Kayser-Bricker; Frederic Lamoliatte; Akshada Gajbhiye; Simon Davis; Hannah C Scott; Emma Murphy; Katherine England; Heather Mortiboys; David Komander; Matthias Trost; Benedikt M Kessler; Stephanos Ioannidis; Michael K Ahlijanian; Sylvie Urbé; Michael J Clague

doi:10.26508/lsa.202000768

Research Article

Open Access

USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

View ORCID ProfileEmma V Rusilowicz-Jones, View ORCID ProfileJane Jardine, View ORCID ProfileAndreas Kallinos, Adan Pinto-Fernandez, View ORCID ProfileFranziska Guenther, Mariacarmela Giurrandino, View ORCID ProfileFrancesco G Barone, Katy McCarron, Christopher J Burke, Alejandro Murad, View ORCID ProfileAitor Martinez, Elena Marcassa, Malte Gersch, Alexandre J Buckmelter, Katherine J Kayser-Bricker, Frederic Lamoliatte, Akshada Gajbhiye, View ORCID ProfileSimon Davis, Hannah C Scott, Emma Murphy, Katherine England, View ORCID ProfileHeather Mortiboys, David Komander, Matthias Trost, Benedikt M Kessler, Stephanos Ioannidis, Michael K Ahlijanian, View ORCID ProfileSylvie Urbé Correspondence email, View ORCID ProfileMichael J Clague Correspondence email

Emma V Rusilowicz-Jones

1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

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Jane Jardine

1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

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Andreas Kallinos

1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

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Adan Pinto-Fernandez

2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK

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Franziska Guenther

3Alzheimer’s Research UK, Oxford Drug Discovery Institute, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK

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Mariacarmela Giurrandino

3Alzheimer’s Research UK, Oxford Drug Discovery Institute, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK

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Francesco G Barone

1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

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Katy McCarron

1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

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Christopher J Burke

4FORMA Therapeutics, Watertown, MA, USA

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Alejandro Murad

4FORMA Therapeutics, Watertown, MA, USA

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Aitor Martinez

1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

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Elena Marcassa

1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

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Malte Gersch

5Chemical Genomics Centre, Max-Planck-Institute of Molecular Physiology, Dortmund, Germany

6Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Dortmund, Germany

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Alexandre J Buckmelter

4FORMA Therapeutics, Watertown, MA, USA

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Katherine J Kayser-Bricker

4FORMA Therapeutics, Watertown, MA, USA

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Frederic Lamoliatte

10Laboratory for Biological Mass Spectrometry, Newcastle University Biosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle, UK

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Akshada Gajbhiye

10Laboratory for Biological Mass Spectrometry, Newcastle University Biosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle, UK

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Simon Davis

2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK

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Hannah C Scott

2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK

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Emma Murphy

3Alzheimer’s Research UK, Oxford Drug Discovery Institute, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK

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Katherine England

3Alzheimer’s Research UK, Oxford Drug Discovery Institute, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK

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Heather Mortiboys

7Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK

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David Komander

8Ubiquitin Signalling Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia

9Department of Medical Biology, University of Melbourne, Melbourne, Australia

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Matthias Trost

10Laboratory for Biological Mass Spectrometry, Newcastle University Biosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle, UK

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Benedikt M Kessler

2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK

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Stephanos Ioannidis

4FORMA Therapeutics, Watertown, MA, USA

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Michael K Ahlijanian

4FORMA Therapeutics, Watertown, MA, USA

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Sylvie Urbé

1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

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For correspondence: urbe@liv.ac.uk

Michael J Clague

1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

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For correspondence: clague@liv.ac.uk

Published 7 July 2020. DOI: 10.26508/lsa.202000768

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Citation Tools

USP30 sets a mitophagy trigger

Emma V Rusilowicz-Jones, Jane Jardine, Andreas Kallinos, Adan Pinto-Fernandez, Franziska Guenther, Mariacarmela Giurrandino, Francesco G Barone, Katy McCarron, Christopher J Burke, Alejandro Murad, Aitor Martinez, Elena Marcassa, Malte Gersch, Alexandre J Buckmelter, Katherine J Kayser-Bricker, Frederic Lamoliatte, Akshada Gajbhiye, Simon Davis, Hannah C Scott, Emma Murphy, Katherine England, Heather Mortiboys, David Komander, Matthias Trost, Benedikt M Kessler, Stephanos Ioannidis, Michael K Ahlijanian, Sylvie Urbé, Michael J Clague

Life Science Alliance Jul 2020, 3 (8) e202000768; DOI: 10.26508/lsa.202000768