Research Article
Open Access
USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation
View ORCID ProfileEmma V Rusilowicz-Jones, View ORCID ProfileJane Jardine, View ORCID ProfileAndreas Kallinos, Adan Pinto-Fernandez, View ORCID ProfileFranziska Guenther, Mariacarmela Giurrandino, View ORCID ProfileFrancesco G Barone, Katy McCarron, Christopher J Burke, Alejandro Murad, View ORCID ProfileAitor Martinez, Elena Marcassa, Malte Gersch, Alexandre J Buckmelter, Katherine J Kayser-Bricker, Frederic Lamoliatte, Akshada Gajbhiye, View ORCID ProfileSimon Davis, Hannah C Scott, Emma Murphy, Katherine England, View ORCID ProfileHeather Mortiboys, David Komander, Matthias Trost, Benedikt M Kessler, Stephanos Ioannidis, Michael K Ahlijanian, View ORCID ProfileSylvie Urbé Correspondence email, View ORCID ProfileMichael J Clague Correspondence email
Emma V Rusilowicz-Jones
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
Jane Jardine
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
Andreas Kallinos
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
Adan Pinto-Fernandez
2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Franziska Guenther
3Alzheimer’s Research UK, Oxford Drug Discovery Institute, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Mariacarmela Giurrandino
3Alzheimer’s Research UK, Oxford Drug Discovery Institute, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Francesco G Barone
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
Katy McCarron
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
Christopher J Burke
4FORMA Therapeutics, Watertown, MA, USA
Alejandro Murad
4FORMA Therapeutics, Watertown, MA, USA
Aitor Martinez
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
Elena Marcassa
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
Malte Gersch
5Chemical Genomics Centre, Max-Planck-Institute of Molecular Physiology, Dortmund, Germany
6Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Dortmund, Germany
Alexandre J Buckmelter
4FORMA Therapeutics, Watertown, MA, USA
Katherine J Kayser-Bricker
4FORMA Therapeutics, Watertown, MA, USA
Frederic Lamoliatte
10Laboratory for Biological Mass Spectrometry, Newcastle University Biosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle, UK
Akshada Gajbhiye
10Laboratory for Biological Mass Spectrometry, Newcastle University Biosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle, UK
Simon Davis
2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Hannah C Scott
2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Emma Murphy
3Alzheimer’s Research UK, Oxford Drug Discovery Institute, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Katherine England
3Alzheimer’s Research UK, Oxford Drug Discovery Institute, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Heather Mortiboys
7Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK
David Komander
8Ubiquitin Signalling Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Medical Biology, University of Melbourne, Melbourne, Australia
Matthias Trost
10Laboratory for Biological Mass Spectrometry, Newcastle University Biosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle, UK
Benedikt M Kessler
2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Stephanos Ioannidis
4FORMA Therapeutics, Watertown, MA, USA
Michael K Ahlijanian
4FORMA Therapeutics, Watertown, MA, USA
Sylvie Urbé
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
Michael J Clague
1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
Published 7 July 2020. DOI: 10.26508/lsa.202000768
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USP30 sets a mitophagy trigger
Emma V Rusilowicz-Jones, Jane Jardine, Andreas Kallinos, Adan Pinto-Fernandez, Franziska Guenther, Mariacarmela Giurrandino, Francesco G Barone, Katy McCarron, Christopher J Burke, Alejandro Murad, Aitor Martinez, Elena Marcassa, Malte Gersch, Alexandre J Buckmelter, Katherine J Kayser-Bricker, Frederic Lamoliatte, Akshada Gajbhiye, Simon Davis, Hannah C Scott, Emma Murphy, Katherine England, Heather Mortiboys, David Komander, Matthias Trost, Benedikt M Kessler, Stephanos Ioannidis, Michael K Ahlijanian, Sylvie Urbé, Michael J Clague
Life Science Alliance Jul 2020, 3 (8) e202000768; DOI: 10.26508/lsa.202000768
USP30 sets a mitophagy trigger
Emma V Rusilowicz-Jones, Jane Jardine, Andreas Kallinos, Adan Pinto-Fernandez, Franziska Guenther, Mariacarmela Giurrandino, Francesco G Barone, Katy McCarron, Christopher J Burke, Alejandro Murad, Aitor Martinez, Elena Marcassa, Malte Gersch, Alexandre J Buckmelter, Katherine J Kayser-Bricker, Frederic Lamoliatte, Akshada Gajbhiye, Simon Davis, Hannah C Scott, Emma Murphy, Katherine England, Heather Mortiboys, David Komander, Matthias Trost, Benedikt M Kessler, Stephanos Ioannidis, Michael K Ahlijanian, Sylvie Urbé, Michael J Clague
Life Science Alliance Jul 2020, 3 (8) e202000768; DOI: 10.26508/lsa.202000768
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Volume 3, No. 8
August 2020
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