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Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells

View ORCID ProfileSomsundar V Muralidharan, View ORCID ProfileLisa M Nilsson, View ORCID ProfileMattias F Lindberg, View ORCID ProfileJonas A Nilsson  Correspondence email
Somsundar V Muralidharan
Department of Surgery, Sahlgrenska Cancer Center, Institute of Clinical Sciences at University of Gothenburg, Gothenburg, Sweden
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  • ORCID record for Somsundar V Muralidharan
Lisa M Nilsson
Department of Surgery, Sahlgrenska Cancer Center, Institute of Clinical Sciences at University of Gothenburg, Gothenburg, Sweden
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  • ORCID record for Lisa M Nilsson
Mattias F Lindberg
Department of Surgery, Sahlgrenska Cancer Center, Institute of Clinical Sciences at University of Gothenburg, Gothenburg, Sweden
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  • ORCID record for Mattias F Lindberg
Jonas A Nilsson
Department of Surgery, Sahlgrenska Cancer Center, Institute of Clinical Sciences at University of Gothenburg, Gothenburg, Sweden
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  • ORCID record for Jonas A Nilsson
  • For correspondence: jonas.a.nilsson@surgery.gu.se
Published 22 June 2020. DOI: 10.26508/lsa.202000671
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Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells
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Chk1 kinase activity is needed for mouse embryos and tumors
Somsundar V Muralidharan, Lisa M Nilsson, Mattias F Lindberg, Jonas A Nilsson
Life Science Alliance Jun 2020, 3 (8) e202000671; DOI: 10.26508/lsa.202000671

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Chk1 kinase activity is needed for mouse embryos and tumors
Somsundar V Muralidharan, Lisa M Nilsson, Mattias F Lindberg, Jonas A Nilsson
Life Science Alliance Jun 2020, 3 (8) e202000671; DOI: 10.26508/lsa.202000671
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Volume 3, No. 8
August 2020
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  • Genetics, Gene Therapy & Genetic Disease
  • Cell Biology
  • Cancer

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