STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers

Petra van der Lelij; Joseph A Newman; Simone Lieb; Julian Jude; Vittorio Katis; Thomas Hoffmann; Matthias Hinterndorfer; Gerd Bader; Norbert Kraut; Mark A Pearson; Jan-Michael Peters; Johannes Zuber; Opher Gileadi; Mark Petronczki

doi:10.26508/lsa.202000725

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STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers

View ORCID ProfilePetra van der Lelij, Joseph A Newman, Simone Lieb, Julian Jude, Vittorio Katis, Thomas Hoffmann, Matthias Hinterndorfer, Gerd Bader, Norbert Kraut, Mark A Pearson, Jan-Michael Peters, Johannes Zuber Correspondence email, Opher Gileadi Correspondence email, View ORCID ProfileMark Petronczki Correspondence email

Petra van der Lelij

1Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria

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ORCID record for Petra van der Lelij

Joseph A Newman

2Structural Genomics Consortium, University of Oxford, Oxford, UK

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Simone Lieb

3Boehringer Ingelheim Regional Center Vienna (RCV) GmbH & Co KG, Vienna, Austria

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Julian Jude

1Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria

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Vittorio Katis

2Structural Genomics Consortium, University of Oxford, Oxford, UK

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Thomas Hoffmann

1Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria

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Matthias Hinterndorfer

1Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria

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Gerd Bader

3Boehringer Ingelheim Regional Center Vienna (RCV) GmbH & Co KG, Vienna, Austria

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Norbert Kraut

3Boehringer Ingelheim Regional Center Vienna (RCV) GmbH & Co KG, Vienna, Austria

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Mark A Pearson

3Boehringer Ingelheim Regional Center Vienna (RCV) GmbH & Co KG, Vienna, Austria

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Jan-Michael Peters

1Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria

4Medical University of Vienna, VBC, Vienna, Austria

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Johannes Zuber

1Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria

4Medical University of Vienna, VBC, Vienna, Austria

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For correspondence: johannes.zuber@imp.ac.at

Opher Gileadi

2Structural Genomics Consortium, University of Oxford, Oxford, UK

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For correspondence: opher.gileadi@sgc.ox.ac.uk

Mark Petronczki

3Boehringer Ingelheim Regional Center Vienna (RCV) GmbH & Co KG, Vienna, Austria

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ORCID record for Mark Petronczki
For correspondence: mark_paul.petronczki@boehringer-ingelheim.com

Published 28 May 2020. DOI: 10.26508/lsa.202000725

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Exploiting cohesin synthetic lethality

Petra van der Lelij, Joseph A Newman, Simone Lieb, Julian Jude, Vittorio Katis, Thomas Hoffmann, Matthias Hinterndorfer, Gerd Bader, Norbert Kraut, Mark A Pearson, Jan-Michael Peters, Johannes Zuber, Opher Gileadi, Mark Petronczki

Life Science Alliance May 2020, 3 (7) e202000725; DOI: 10.26508/lsa.202000725