Unbiased yeast screens identify cellular pathways affected in Niemann–Pick disease type C

Alexandria Colaco; María E Fernández-Suárez; Dawn Shepherd; Lihi Gal; Chen Bibi; Silvia Chuartzman; Alan Diot; Karl Morten; Emily Eden; Forbes D Porter; Joanna Poulton; Nick Platt; Maya Schuldiner; Frances M Platt

doi:10.26508/lsa.201800253

Research Article

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Unbiased yeast screens identify cellular pathways affected in Niemann–Pick disease type C

View ORCID ProfileAlexandria Colaco, View ORCID ProfileMaría E Fernández-Suárez, Dawn Shepherd, Lihi Gal, View ORCID ProfileChen Bibi, Silvia Chuartzman, View ORCID ProfileAlan Diot, Karl Morten, View ORCID ProfileEmily Eden, Forbes D Porter, Joanna Poulton, View ORCID ProfileNick Platt, View ORCID ProfileMaya Schuldiner, View ORCID ProfileFrances M Platt Correspondence email

Alexandria Colaco

1Department of Pharmacology, University of Oxford, Oxford, UK

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María E Fernández-Suárez

1Department of Pharmacology, University of Oxford, Oxford, UK

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Dawn Shepherd

1Department of Pharmacology, University of Oxford, Oxford, UK

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Lihi Gal

2Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

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Chen Bibi

2Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

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Silvia Chuartzman

2Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

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Alan Diot

3Nuffield Department of Obstetrics and Gynecology, University of Oxford, Oxford, UK

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Karl Morten

3Nuffield Department of Obstetrics and Gynecology, University of Oxford, Oxford, UK

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Emily Eden

4Institute of Ophthalmology–Cell Biology, University College London, London, UK

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Forbes D Porter

5Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD, USA

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Joanna Poulton

3Nuffield Department of Obstetrics and Gynecology, University of Oxford, Oxford, UK

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Nick Platt

1Department of Pharmacology, University of Oxford, Oxford, UK

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Maya Schuldiner

2Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

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Frances M Platt

1Department of Pharmacology, University of Oxford, Oxford, UK

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For correspondence: frances.platt@pharm.ox.ac.uk

Published 2 June 2020. DOI: 10.26508/lsa.201800253

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Yeast as a model for NPC disease

Alexandria Colaco, María E Fernández-Suárez, Dawn Shepherd, Lihi Gal, Chen Bibi, Silvia Chuartzman, Alan Diot, Karl Morten, Emily Eden, Forbes D Porter, Joanna Poulton, Nick Platt, Maya Schuldiner, Frances M Platt

Life Science Alliance Jun 2020, 3 (7) e201800253; DOI: 10.26508/lsa.201800253