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Research Articles
Regulation of axonal morphogenesis by the mitochondrial protein Efhd1Ablation of the mitochondrial protein Efhd1 in mice interferes with normal development of sensory axons and results in mitochondrial dysfunction associated with activation of cellular stress pathways.
Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesisAlthough hair bulge stem cells are not the cancer cells-of-origin, they contribute to two-stage DMBA/TPA skin carcinogenesis in an α3β1-dependent manner.
Structural basis of HapEP88L-linked antifungal triazole resistance in Aspergillus fumigatusThe mutation P88L in subunit HapE of the CCAAT transcription factor causes resistance of Aspergillus fumigatus to azole drugs due to altered binding, bending, and transcription of target promoters.
STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancersThis work highlights the degradation of STAG1 and inhibition of its interaction with cohesin as promising therapeutic strategies for exploiting synthetic lethality to treat STAG2-mutated tumors and lays the groundwork for the discovery of STAG1-directed small molecules.
Genetic targeting of neurogenic precursors in the adult forebrain ventricular epitheliumIn vivo evidence for precursors that produce neurons independent of neurosphere-forming neural stem cells suggests the adult forebrain, like the developing brain, has two distinct neurogenic pathways.
Unbiased yeast screens identify cellular pathways affected in Niemann–Pick disease type CThree independent yeast genetic screens were performed identifying proteins and pathways contributing to the pathogenesis of NPC disease and suggesting new therapeutic avenues.
Snail augments fatty acid oxidation by suppression of mitochondrial ACC2 during cancer progressionThis study reports a mechanism of mitochondrial ATP generation whereby EMT-inducer Snail controls ACC2 abundance and subsequent fatty acid oxidation to support cancer survival under starvation conditions.
Methods
Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondriaA novel, machine-learning approach to quantify cristae density and architecture in live-cell super-resolution imaging characterizes the ultrastructural parameters of individual mitochondria over time.
Resources
Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancerEngaging the immunoproteasome helps maintain proteostasis during TNBC development, but ultimately leads to increased immune visibility and favorable prognosis. Assessing i-proteasome expression could augment the prognostic and/or predictive value of TILs assessment in diagnostic practice.
Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cellsThis comprehensive study identifies multiple sclerosis risk expression quantitative trait loci in purified immune cell types.
