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Table of Contents

July 2020 | Volume 3, No. 7

Research Articles

  • Regulation of axonal morphogenesis by the mitochondrial protein Efhd1
    Open Access
    Regulation of axonal morphogenesis by the mitochondrial protein Efhd1

    Valeria Ulisse, Swagata Dey, Deborah E Rothbard, Einav Zeevi, Irena Gokhman, Tali Dadosh, Adi Minis, Avraham Yaron

    Valeria Ulisse ... Avraham Yaron

    Published 15 May 2020

    Ablation of the mitochondrial protein Efhd1 in mice interferes with normal development of sensory axons and results in mitochondrial dysfunction associated with activation of cellular stress pathways.

  • Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis
    Open Access
    Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis

    Veronika Ramovs, Ana Krotenberg Garcia, Ji-Ying Song, Iris de Rink, Maaike Kreft, Roel Goldschmeding, Arnoud Sonnenberg

    Veronika Ramovs ... Arnoud Sonnenberg

    Published 18 May 2020

    Although hair bulge stem cells are not the cancer cells-of-origin, they contribute to two-stage DMBA/TPA skin carcinogenesis in an α3β1-dependent manner.

  • Structural basis of HapE<sup>P88L</sup>-linked antifungal triazole resistance in <em>Aspergillus fumigatus</em>
    Open Access
    Structural basis of HapEP88L-linked antifungal triazole resistance in Aspergillus fumigatus

    Peter Hortschansky, Matthias Misslinger, Jasmin Mörl, Fabio Gsaller, Michael J Bromley, Axel A Brakhage, Michael Groll, Hubertus Haas, Eva M Huber

    Peter Hortschansky ... Eva M Huber

    Published 28 May 2020

    The mutation P88L in subunit HapE of the CCAAT transcription factor causes resistance of Aspergillus fumigatus to azole drugs due to altered binding, bending, and transcription of target promoters.

  • STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers
    Open Access
    STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers

    Petra van der Lelij, Joseph A Newman, Simone Lieb, Julian Jude, Vittorio Katis, Thomas Hoffmann, Matthias Hinterndorfer, Gerd Bader, Norbert Kraut, Mark A Pearson, Jan-Michael Peters, Johannes Zuber, Opher Gileadi, Mark Petronczki

    Petra van der Lelij ... Mark Petronczki

    Published 28 May 2020

    This work highlights the degradation of STAG1 and inhibition of its interaction with cohesin as promising therapeutic strategies for exploiting synthetic lethality to treat STAG2-mutated tumors and lays the groundwork for the discovery of STAG1-directed small molecules.

  • Genetic targeting of neurogenic precursors in the adult forebrain ventricular epithelium
    Open Access
    Genetic targeting of neurogenic precursors in the adult forebrain ventricular epithelium

    Sandra E Joppé, Loïc M Cochard, Louis-Charles Levros, Laura K Hamilton, Pierre Ameslon, Anne Aumont, Fanie Barnabé-Heider, Karl JL Fernandes

    Sandra E Joppé ... Karl JL Fernandes

    Published 1 June 2020

    In vivo evidence for precursors that produce neurons independent of neurosphere-forming neural stem cells suggests the adult forebrain, like the developing brain, has two distinct neurogenic pathways.

  • Unbiased yeast screens identify cellular pathways affected in Niemann–Pick disease type C
    Open Access
    Unbiased yeast screens identify cellular pathways affected in Niemann–Pick disease type C

    Alexandria Colaco, María E Fernández-Suárez, Dawn Shepherd, Lihi Gal, Chen Bibi, Silvia Chuartzman, Alan Diot, Karl Morten, Emily Eden, Forbes D Porter, Joanna Poulton, Nick Platt, Maya Schuldiner, Frances M Platt

    Alexandria Colaco ... Frances M Platt

    Published 2 June 2020

    Three independent yeast genetic screens were performed identifying proteins and pathways contributing to the pathogenesis of NPC disease and suggesting new therapeutic avenues.

  • Snail augments fatty acid oxidation by suppression of mitochondrial ACC2 during cancer progression
    Open Access
    Snail augments fatty acid oxidation by suppression of mitochondrial ACC2 during cancer progression

    Ji Hye Yang, Nam Hee Kim, Jun Seop Yun, Eunae Sandra Cho, Yong Hoon Cha, Sue Bean Cho, Seon-Hyeong Lee, So Young Cha, Soo-Youl Kim, Jiwon Choi, Tin-Tin Manh Nguyen, Sunghyouk Park, Hyun Sil Kim, Jong In Yook

    Ji Hye Yang ... Jong In Yook

    Published 2 June 2020

    This study reports a mechanism of mitochondrial ATP generation whereby EMT-inducer Snail controls ACC2 abundance and subsequent fatty acid oxidation to support cancer survival under starvation conditions.

Methods

  • Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondria
    Open Access
    Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondria

    Mayuko Segawa, Dane M Wolf, Nan W Hultgren, David S Williams, Alexander M van der Bliek, David B Shackelford, Marc Liesa, Orian S Shirihai

    Mayuko Segawa ... Orian S Shirihai

    Published 4 June 2020

    A novel, machine-learning approach to quantify cristae density and architecture in live-cell super-resolution imaging characterizes the ultrastructural parameters of individual mitochondria over time.

Resources

  • Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer
    Open Access
    Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer

    Alaknanda Adwal, Priyakshi Kalita-de Croft, Reshma Shakya, Malcolm Lim, Emarene Kalaw, Lucinda D Taege, Amy E McCart Reed, Sunil R Lakhani, David F Callen, Jodi M Saunus

    Alaknanda Adwal ... Jodi M Saunus

    Published 18 May 2020

    Engaging the immunoproteasome helps maintain proteostasis during TNBC development, but ultimately leads to increased immune visibility and favorable prognosis. Assessing i-proteasome expression could augment the prognostic and/or predictive value of TILs assessment in diagnostic practice.

  • Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells
    Open Access
    Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells

    Melissa M Gresle, Margaret A Jordan, Jim Stankovich, Tim Spelman, Laura J Johnson, Louise Laverick, Alison Hamlett, Letitia D Smith, Vilija G Jokubaitis, Josephine Baker, Jodi Haartsen, Bruce Taylor, Jac Charlesworth, Melanie Bahlo, Terence P Speed, Matthew A Brown, Judith Field, Alan G Baxter, Helmut Butzkueven

    Melissa M Gresle ... Helmut Butzkueven

    Published 9 June 2020

    This comprehensive study identifies multiple sclerosis risk expression quantitative trait loci in purified immune cell types.

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Volume 3, No. 7
July 2020
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