Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

Rosalie Heilig; Marisa Dilucca; Dave Boucher; Kaiwen W Chen; Dora Hancz; Benjamin Demarco; Kateryna Shkarina; Petr Broz

doi:10.26508/lsa.202000735

Research Article

Open Access

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

Rosalie Heilig, Marisa Dilucca, View ORCID ProfileDave Boucher, View ORCID ProfileKaiwen W Chen, Dora Hancz, View ORCID ProfileBenjamin Demarco, Kateryna Shkarina, View ORCID ProfilePetr Broz Correspondence email

Rosalie Heilig

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland

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Marisa Dilucca

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland

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Dave Boucher

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland

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ORCID record for Dave Boucher

Kaiwen W Chen

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland

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Dora Hancz

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland

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Benjamin Demarco

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland

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Kateryna Shkarina

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland

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Petr Broz

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland

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For correspondence: petr.broz@unil.ch

Published 28 April 2020. DOI: 10.26508/lsa.202000735

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vol. 3 no. 6 e202000735

DOI

https://doi.org/10.26508/lsa.202000735

PubMed

32345661

Published By

Life Science Alliance

Online ISSN

2575-1077

History

Received April 7, 2020
Revision received April 16, 2020
Accepted April 16, 2020
Published online April 28, 2020.

Author Information

Rosalie Heilig,
Marisa Dilucca,
Dave Boucher,
Kaiwen W Chen,
Dora Hancz,
Benjamin Demarco,
Kateryna Shkarina and
Petr Broz⇑

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland

Correspondence: petr.broz{at}unil.ch

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Funding

European Research Council
ERC-2017-CoG 770988
P Broz
Swiss National Science Foundation
310030_175576

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GSDMD-independent cell death requires casp1-driven Bid truncation

Rosalie Heilig, Marisa Dilucca, Dave Boucher, Kaiwen W Chen, Dora Hancz, Benjamin Demarco, Kateryna Shkarina, Petr Broz

Life Science Alliance Apr 2020, 3 (6) e202000735; DOI: 10.26508/lsa.202000735

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GSDMD-independent cell death requires casp1-driven Bid truncation

Rosalie Heilig, Marisa Dilucca, Dave Boucher, Kaiwen W Chen, Dora Hancz, Benjamin Demarco, Kateryna Shkarina, Petr Broz

Life Science Alliance Apr 2020, 3 (6) e202000735; DOI: 10.26508/lsa.202000735

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Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

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