Pancreatic cancer triggers diabetes through TGF-β–mediated selective depletion of islet β-cells

Parash Parajuli; Thien Ly Nguyen; Céline Prunier; Mohammed S Razzaque; Keli Xu; Azeddine Atfi

doi:10.26508/lsa.201900573

Research Article

Open Access

Pancreatic cancer triggers diabetes through TGF-β–mediated selective depletion of islet β-cells

Parash Parajuli, Thien Ly Nguyen, Céline Prunier, View ORCID ProfileMohammed S Razzaque, View ORCID ProfileKeli Xu, View ORCID ProfileAzeddine Atfi Correspondence email

Parash Parajuli

1Cellular and Molecular Pathogenesis Division, Department of Pathology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA

2Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA

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Thien Ly Nguyen

1Cellular and Molecular Pathogenesis Division, Department of Pathology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA

2Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA

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Céline Prunier

3Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, Paris, France

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Mohammed S Razzaque

4Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, USA

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ORCID record for Mohammed S Razzaque

Keli Xu

2Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA

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Azeddine Atfi

1Cellular and Molecular Pathogenesis Division, Department of Pathology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA

2Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA

3Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, Paris, France

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For correspondence: azeddine.atfi@inserm.fr

Published 5 May 2020. DOI: 10.26508/lsa.201900573

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Pancreatic cancer-associated diabetes