MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling

Hoi-Lam Ngan; Yuchen Liu; Andrew Yuon Fong; Peony Hiu Yan Poon; Chun Kit Yeung; Sharon Suet Man Chan; Alexandria Lau; Wenying Piao; Hui Li; Jessie Sze Wing Tse; Kwok-Wai Lo; Sze Man Chan; Yu-Xiong Su; Jason Ying Kuen Chan; Chin Wang Lau; Gordon B Mills; Jennifer Rubin Grandis; Vivian Wai Yan Lui

doi:10.26508/lsa.201900545

Research Article

Open Access

MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling

Hoi-Lam Ngan, View ORCID ProfileYuchen Liu, Andrew Yuon Fong, Peony Hiu Yan Poon, Chun Kit Yeung, Sharon Suet Man Chan, Alexandria Lau, Wenying Piao, Hui Li, Jessie Sze Wing Tse, Kwok-Wai Lo, Sze Man Chan, Yu-Xiong Su, View ORCID ProfileJason Ying Kuen Chan, Chin Wang Lau, Gordon B Mills, Jennifer Rubin Grandis, View ORCID ProfileVivian Wai Yan Lui Correspondence email

Hoi-Lam Ngan

1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR

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Yuchen Liu

1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR

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Andrew Yuon Fong

2Department of Biochemistry, Case Western Reserve University, Cleveland, OH, USA

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Peony Hiu Yan Poon

1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR

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Chun Kit Yeung

1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR

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Sharon Suet Man Chan

3Faculty of Medicine, Imperial College London, London, UK

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Alexandria Lau

1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR

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Wenying Piao

1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR

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Hui Li

1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR

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Jessie Sze Wing Tse

1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR

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Kwok-Wai Lo

4Department of Anatomical and Cellular Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR

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Sze Man Chan

1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR

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Yu-Xiong Su

5Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong SAR

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Jason Ying Kuen Chan

6Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR

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Chin Wang Lau

7Department of Otorhinolaryngology Head and Neck, Yan Chai Hospital, Hong Kong, Hong Kong SAR

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Gordon B Mills

8Department of Cell, Development and Cancer Biology, Knight Cancer Institute, Oregon Health and Sciences University, Portland, OR, USA

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Jennifer Rubin Grandis

9Department of Otolaryngology–Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA

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Vivian Wai Yan Lui

1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR

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ORCID record for Vivian Wai Yan Lui
For correspondence: vlui002@cuhk.edu.hk

Published 7 May 2020. DOI: 10.26508/lsa.201900545

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Citation Tools

Survival-favoring biology of MAPK-mutant HNSCC

Hoi-Lam Ngan, Yuchen Liu, Andrew Yuon Fong, Peony Hiu Yan Poon, Chun Kit Yeung, Sharon Suet Man Chan, Alexandria Lau, Wenying Piao, Hui Li, Jessie Sze Wing Tse, Kwok-Wai Lo, Sze Man Chan, Yu-Xiong Su, Jason Ying Kuen Chan, Chin Wang Lau, Gordon B Mills, Jennifer Rubin Grandis, Vivian Wai Yan Lui

Life Science Alliance May 2020, 3 (6) e201900545; DOI: 10.26508/lsa.201900545