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MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling

Hoi-Lam Ngan, View ORCID ProfileYuchen Liu, Andrew Yuon Fong, Peony Hiu Yan Poon, Chun Kit Yeung, Sharon Suet Man Chan, Alexandria Lau, Wenying Piao, Hui Li, Jessie Sze Wing Tse, Kwok-Wai Lo, Sze Man Chan, Yu-Xiong Su, View ORCID ProfileJason Ying Kuen Chan, Chin Wang Lau, Gordon B Mills, Jennifer Rubin Grandis, View ORCID ProfileVivian Wai Yan Lui  Correspondence email
Hoi-Lam Ngan
1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR
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Yuchen Liu
1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR
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  • ORCID record for Yuchen Liu
Andrew Yuon Fong
2Department of Biochemistry, Case Western Reserve University, Cleveland, OH, USA
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Peony Hiu Yan Poon
1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR
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Chun Kit Yeung
1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR
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Sharon Suet Man Chan
3Faculty of Medicine, Imperial College London, London, UK
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Alexandria Lau
1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR
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Wenying Piao
1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR
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Hui Li
1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR
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Jessie Sze Wing Tse
1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR
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Kwok-Wai Lo
4Department of Anatomical and Cellular Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR
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Sze Man Chan
1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR
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Yu-Xiong Su
5Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong SAR
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Jason Ying Kuen Chan
6Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR
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Chin Wang Lau
7Department of Otorhinolaryngology Head and Neck, Yan Chai Hospital, Hong Kong, Hong Kong SAR
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Gordon B Mills
8Department of Cell, Development and Cancer Biology, Knight Cancer Institute, Oregon Health and Sciences University, Portland, OR, USA
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Jennifer Rubin Grandis
9Department of Otolaryngology–Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA
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Vivian Wai Yan Lui
1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR
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  • ORCID record for Vivian Wai Yan Lui
  • For correspondence: vlui002@cuhk.edu.hk
Published 7 May 2020. DOI: 10.26508/lsa.201900545
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Article Information

vol. 3 no. 6 e201900545
DOI 
https://doi.org/10.26508/lsa.201900545
PubMed 
32381551

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received September 9, 2019
  • Revision received April 17, 2020
  • Accepted April 17, 2020
  • Published online May 7, 2020.

Copyright & Usage 
© 2020 Ngan et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Hoi-Lam Ngan1,*,
  2. Yuchen Liu1,*,
  3. Andrew Yuon Fong2,
  4. Peony Hiu Yan Poon1,
  5. Chun Kit Yeung1,
  6. Sharon Suet Man Chan3,
  7. Alexandria Lau1,
  8. Wenying Piao1,
  9. Hui Li1,
  10. Jessie Sze Wing Tse1,
  11. Kwok-Wai Lo4,
  12. Sze Man Chan1,
  13. Yu-Xiong Su5,
  14. Jason Ying Kuen Chan6,
  15. Chin Wang Lau7,
  16. Gordon B Mills8,
  17. Jennifer Rubin Grandis9 and
  18. Vivian Wai Yan Lui1⇑
  1. 1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR
  2. 2Department of Biochemistry, Case Western Reserve University, Cleveland, OH, USA
  3. 3Faculty of Medicine, Imperial College London, London, UK
  4. 4Department of Anatomical and Cellular Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR
  5. 5Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong SAR
  6. 6Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR
  7. 7Department of Otorhinolaryngology Head and Neck, Yan Chai Hospital, Hong Kong, Hong Kong SAR
  8. 8Department of Cell, Development and Cancer Biology, Knight Cancer Institute, Oregon Health and Sciences University, Portland, OR, USA
  9. 9Department of Otolaryngology–Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA
  1. Correspondence: vlui002{at}cuhk.edu.hk
  1. ↵* Hoi-Lam Ngan and Yuchen Liu contributed equally to this work

View Full Text

Funding

  • General Research Fund

    #17114814
    VWY Lui
  • General Research Fund, Research Grant Council, Hong Kong government

    VWY Lui
  • Hong Kong SAR

    #17121616, #14168517
    VWY Lui
  • Research Impact Fund

    #R4017-18
    VWY Lui
  • Health and Medical Research Fund

    HMRF#15160691
    VWY Lui
  • University-Industry Collaboration Program

    UIM/329
    VWY Lui
  • Hong Kong Cancer Fund

    VWY Lui
  • Innovation and Technology Fund

    PiH/052/18 and PiH/234/18
    YCL, W Piao
  • Dr Stanley Ho Medical Foundation and General Research Fund

    #14109716; #14108818
    JYK Chan
  • Hong Kong Research Grant Council-General Research Fund

    #17120718
    YX Su
  • National Institudes of Health

    R35CA231998, U54CA209891, R01DE023685, and R01DE028289
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Survival-favoring biology of MAPK-mutant HNSCC
Hoi-Lam Ngan, Yuchen Liu, Andrew Yuon Fong, Peony Hiu Yan Poon, Chun Kit Yeung, Sharon Suet Man Chan, Alexandria Lau, Wenying Piao, Hui Li, Jessie Sze Wing Tse, Kwok-Wai Lo, Sze Man Chan, Yu-Xiong Su, Jason Ying Kuen Chan, Chin Wang Lau, Gordon B Mills, Jennifer Rubin Grandis, Vivian Wai Yan Lui
Life Science Alliance May 2020, 3 (6) e201900545; DOI: 10.26508/lsa.201900545

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Survival-favoring biology of MAPK-mutant HNSCC
Hoi-Lam Ngan, Yuchen Liu, Andrew Yuon Fong, Peony Hiu Yan Poon, Chun Kit Yeung, Sharon Suet Man Chan, Alexandria Lau, Wenying Piao, Hui Li, Jessie Sze Wing Tse, Kwok-Wai Lo, Sze Man Chan, Yu-Xiong Su, Jason Ying Kuen Chan, Chin Wang Lau, Gordon B Mills, Jennifer Rubin Grandis, Vivian Wai Yan Lui
Life Science Alliance May 2020, 3 (6) e201900545; DOI: 10.26508/lsa.201900545
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Volume 3, No. 6
June 2020
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