Table of Contents
Research Articles
Ubiquitin and SUMO conjugation as biomarkers of acute myeloid leukemias response to chemotherapiesThis study describes the identification of a new class of biomarkers of cancer response to therapies based on protein modification by ubiquitin and SUMO and developed tools to validate them in acute myeloid leukemia patient samples.
Oncogenic ALKF1174L drives tumorigenesis in cutaneous squamous cell carcinomaHere, we show for the first time that anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase of the insulin receptor superfamily, plays a pivotal role in the pathogenesis of cSCC.
Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesisThe hereditary spastic paraplegia protein spastin limits the biogenesis of lipid droplets at the endoplasmic reticulum in a microtubule-independent manner, whereas it promotes lipid droplet movement by binding to the microtubules.
Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytesImmunoglobulins shape mitochondrial function by driving ER expansion, this form of metabolic control is independent of the role the immunoglobulins play as part of the antigen receptor on the cell surface.
Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model miceThis study provides novel insight into Crohn’s disease where α-defensin misfolding resulting from excessive ER stress in Paneth cells induces dysbiosis and disease progression.
IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitisIL-36 signaling in keratinocytes is crucial for Aldara-induced psoriasis-like dermatitis by controlling IL-23/IL-17A/IL-22 production and neutrophil recruitment at the third day of treatment.
Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMDCaspase-1 activation in GSDMD-deficient cells induces a rapid form of caspase-3–dependent secondary necrosis that is licenced by caspase-1–induced Bid cleavage and the release of mitochondrial SMAC.
Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolismInhibition of the Alzheimer associated γ-secretase impairs the regulation of cellular lipid droplet homeostasis.
Pancreatic cancer triggers diabetes through TGF-β–mediated selective depletion of islet β-cellsPancreatic ductal adenocarcinoma formation culminates in hyperactivation of transforming growth factor β signaling, which in turn induces selective depletion of β-cell mass and thereby leading to new-onset diabetes.
MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signalingMAPK mutations favor HNSCC survival, revealing the broad clinical utility of MAPK pathway mutations in prognosis and potentially in precision immunotherapy.
