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Table of Contents

June 2020 | Volume 3, No. 6

Research Articles

  • Ubiquitin and SUMO conjugation as biomarkers of acute myeloid leukemias response to chemotherapies
    Open Access
    Ubiquitin and SUMO conjugation as biomarkers of acute myeloid leukemias response to chemotherapies

    Pierre Gâtel, Frédérique Brockly, Christelle Reynes, Manuela Pastore, Yosr Hicheri, Guillaume Cartron, Marc Piechaczyk, Guillaume Bossis

    Pierre Gâtel ... Guillaume Bossis

    Published 17 April 2020

    This study describes the identification of a new class of biomarkers of cancer response to therapies based on protein modification by ubiquitin and SUMO and developed tools to validate them in acute myeloid leukemia patient samples.

  • Oncogenic <em>ALK</em><sup><em>F1174L</em></sup> drives tumorigenesis in cutaneous squamous cell carcinoma
    Open Access
    Oncogenic ALKF1174L drives tumorigenesis in cutaneous squamous cell carcinoma

    Marco Gualandi, Maria Iorio, Olivia Engeler, André Serra-Roma, Giuseppe Gasparre, Johannes H Schulte, Daniel Hohl, Olga Shakhova

    Marco Gualandi ... Olga Shakhova

    Published 20 April 2020

    Here, we show for the first time that anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase of the insulin receptor superfamily, plays a pivotal role in the pathogenesis of cSCC.

  • Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis
    Open Access
    Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis

    Nimesha Tadepalle, Lennart Robers, Matteo Veronese, Peter Zentis, Felix Babatz, Susanne Brodesser, Anja V Gruszczyk, Astrid Schauss, Stefan Höning, Elena I Rugarli

    Nimesha Tadepalle ... Elena I Rugarli

    Published 22 April 2020

    The hereditary spastic paraplegia protein spastin limits the biogenesis of lipid droplets at the endoplasmic reticulum in a microtubule-independent manner, whereas it promotes lipid droplet movement by binding to the microtubules.

  • Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes
    Open Access
    Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes

    Huda Jumaa, Marieta Caganova, Ellen J McAllister, Laura Hoenig, Xiaocui He, Deniz Saltukoglu, Kathrin Brenker, Markus Köhler, Ruth Leben, Anja E Hauser, Raluca Niesner, Klaus Rajewsky, Michael Reth, Julia Jellusova

    Huda Jumaa ... Julia Jellusova

    Published 27 April 2020

    Immunoglobulins shape mitochondrial function by driving ER expansion, this form of metabolic control is independent of the role the immunoglobulins play as part of the antigen receptor on the cell surface.

  • Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model mice
    Open Access
    Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model mice

    Yu Shimizu, Kiminori Nakamura, Aki Yoshii, Yuki Yokoi, Mani Kikuchi, Ryuga Shinozaki, Shunta Nakamura, Shuya Ohira, Rina Sugimoto, Tokiyoshi Ayabe

    Yu Shimizu ... Tokiyoshi Ayabe

    Published 28 April 2020

    This study provides novel insight into Crohn’s disease where α-defensin misfolding resulting from excessive ER stress in Paneth cells induces dysbiosis and disease progression.

  • IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis
    Open Access
    IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis

    Jérémie D Goldstein, Esen Y Bassoy, Assunta Caruso, Jennifer Palomo, Emiliana Rodriguez, Sylvain Lemeille, Cem Gabay

    Jérémie D Goldstein ... Cem Gabay

    Published 28 April 2020

    IL-36 signaling in keratinocytes is crucial for Aldara-induced psoriasis-like dermatitis by controlling IL-23/IL-17A/IL-22 production and neutrophil recruitment at the third day of treatment.

  • Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD
    Open Access
    Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

    Rosalie Heilig, Marisa Dilucca, Dave Boucher, Kaiwen W Chen, Dora Hancz, Benjamin Demarco, Kateryna Shkarina, Petr Broz

    Rosalie Heilig ... Petr Broz

    Published 28 April 2020

    Caspase-1 activation in GSDMD-deficient cells induces a rapid form of caspase-3–dependent secondary necrosis that is licenced by caspase-1–induced Bid cleavage and the release of mitochondrial SMAC.

  • Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism
    Open Access
    Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism

    Esteban Gutierrez, Dieter Lütjohann, Anja Kerksiek, Marietta Fabiano, Naoto Oikawa, Lars Kuerschner, Christoph Thiele, Jochen Walter

    Esteban Gutierrez ... Jochen Walter

    Published 30 April 2020

    Inhibition of the Alzheimer associated γ-secretase impairs the regulation of cellular lipid droplet homeostasis.

  • Pancreatic cancer triggers diabetes through TGF-β–mediated selective depletion of islet β-cells
    Open Access
    Pancreatic cancer triggers diabetes through TGF-β–mediated selective depletion of islet β-cells

    Parash Parajuli, Thien Ly Nguyen, Céline Prunier, Mohammed S Razzaque, Keli Xu, Azeddine Atfi

    Parash Parajuli ... Azeddine Atfi

    Published 5 May 2020

    Pancreatic ductal adenocarcinoma formation culminates in hyperactivation of transforming growth factor β signaling, which in turn induces selective depletion of β-cell mass and thereby leading to new-onset diabetes.

  • MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling
    Open Access
    MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling

    Hoi-Lam Ngan, Yuchen Liu, Andrew Yuon Fong, Peony Hiu Yan Poon, Chun Kit Yeung, Sharon Suet Man Chan, Alexandria Lau, Wenying Piao, Hui Li, Jessie Sze Wing Tse, Kwok-Wai Lo, Sze Man Chan, Yu-Xiong Su, Jason Ying Kuen Chan, Chin Wang Lau, Gordon B Mills, Jennifer Rubin Grandis, Vivian Wai Yan Lui

    Hoi-Lam Ngan ... Vivian Wai Yan Lui

    Published 7 May 2020

    MAPK mutations favor HNSCC survival, revealing the broad clinical utility of MAPK pathway mutations in prognosis and potentially in precision immunotherapy.

Correction

  • Open Access
    Correction: Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain

    Camilla TO Benfield, Farrell MacKenzie, Markus Ritzefeld, Michela Mazzon, Stuart Weston, Edward W Tate, Boon Han Teo, Sarah E Smith, Paul Kellam, Edward C Holmes, Mark Marsh

    Camilla TO Benfield ... Mark Marsh

    Published 29 April 2020
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In this Issue

Volume 3, No. 6
June 2020
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