Table of Contents
Research Articles
- CDKL3 promotes osteosarcoma progression by activating Akt/PKB
This study demonstrates that CDKL3 regulates Akt activation and its downstream targets to promote OS progression, creating a therapeutically targetable vulnerability in treatment of OS.
- Genetic and molecular characterization of multicomponent resistance of Pseudomonas against allicin
A pseudomonad isolated from garlic has multiple copies of genes on three genomic islands that confer resistance to allicin, a secondary plant product and defense substance that causes disulfide stress.
- The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation
The CCR4–NOT complex maintains liver homeostasis by fine-tuning levels of mRNAs, including those for transcription factors, cell cycle regulators, DNA damage response proteins, and liver function–related molecules.
- Defective nucleotide-dependent assembly and membrane fusion in Mfn2 CMT2A variants improved by Bax
Mfn2 CMT2A–associated variants located proximal to the hinge connecting its two extended helical bundles have impaired GTP-dependent assembly and mitochondrial fusion activity, which are both improved by cytosolic Bax.
- Dynamic changes in the regulatory T-cell heterogeneity and function by murine IL-2 mutein
Single-cell RNA-seq analysis reveals that IL-2 mutein treatment expands multiple sub-states of regulatory T cells with superior suppressive function in mice.
- Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice
Wild-type Vav1 and mutant K-Ras synergistically accelerate pancreatic acinar-to-ductal metaplasia (ADM), thus leading to pancreatic ductal adenocarcinoma (PDAC), depending on Vav1’s activity as a GEF for Rac1.
- BMAL1 coordinates energy metabolism and differentiation of pluripotent stem cells
Although pluripotent cells lack circadian oscillations, this study reveals a novel function of the master circadian regulator BMAL1 in metabolism and early differentiation of embryonic stem cells.
- The molecular clock protein Bmal1 regulates cell differentiation in mouse embryonic stem cells
Analysis of the role of the molecular clock protein Bmal1 in pluripotent embryonic stem cells reveals a novel function of circadian proteins in cell differentiation and early embryo development.
- SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration
This study reports that activation of SARM1 causes destruction of NAD pools in photoreceptor cells of the retina and identifies a role for SARM1-dependent photoreceptor cell death in retinal degeneration.
Methods
- Robust production of uniform human cerebral organoids from pluripotent stem cells
By leveraging advances in 3D stem cell culture techniques, the authors describe, characterize and validate a novel platform to efficiently generate morphologically consistent human forebrain cerebral organoids.