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Table of Contents

May 2020 | Volume 3, No. 5

Research Articles

  • CDKL3 promotes osteosarcoma progression by activating Akt/PKB
    Open Access
    CDKL3 promotes osteosarcoma progression by activating Akt/PKB

    Aina He, Lanjing Ma, Yujing Huang, Haijiao Zhang, Wei Duan, Zexu Li, Teng Fei, Junqing Yuan, Hao Wu, Liguo Liu, Yueqing Bai, Wentao Dai, Yonggang Wang, Hongtao Li, Yong Sun, Yaling Wang, Chunyan Wang, Ting Yuan, Qingcheng Yang, Songhai Tian, Min Dong, Ren Sheng, Dongxi Xiang

    Aina He ... Dongxi Xiang

    Published 31 March 2020

    This study demonstrates that CDKL3 regulates Akt activation and its downstream targets to promote OS progression, creating a therapeutically targetable vulnerability in treatment of OS.

  • Genetic and molecular characterization of multicomponent resistance of <em>Pseudomonas</em> against allicin
    Open Access
    Genetic and molecular characterization of multicomponent resistance of Pseudomonas against allicin

    Jan Borlinghaus, Anthony Bolger, Christina Schier, Alexander Vogel, Björn Usadel, Martin CH Gruhlke, Alan J Slusarenko

    Jan Borlinghaus ... Alan J Slusarenko

    Published 31 March 2020

    A pseudomonad isolated from garlic has multiple copies of genes on three genomic islands that confer resistance to allicin, a secondary plant product and defense substance that causes disulfide stress.

  • The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation
    Open Access
    The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation

    Akinori Takahashi, Toru Suzuki, Shou Soeda, Shohei Takaoka, Shungo Kobori, Tomokazu Yamaguchi, Haytham Mohamed Aly Mohamed, Akiko Yanagiya, Takaya Abe, Mayo Shigeta, Yasuhide Furuta, Keiji Kuba, Tadashi Yamamoto

    Akinori Takahashi ... Tadashi Yamamoto

    Published 1 April 2020

    The CCR4–NOT complex maintains liver homeostasis by fine-tuning levels of mRNAs, including those for transcription factors, cell cycle regulators, DNA damage response proteins, and liver function–related molecules.

  • Defective nucleotide-dependent assembly and membrane fusion in Mfn2 CMT2A variants improved by Bax
    Open Access
    Defective nucleotide-dependent assembly and membrane fusion in Mfn2 CMT2A variants improved by Bax

    Nyssa B Samanas, Emily A Engelhart, Suzanne Hoppins

    Nyssa B Samanas ... Suzanne Hoppins

    Published 3 April 2020

    Mfn2 CMT2A–associated variants located proximal to the hinge connecting its two extended helical bundles have impaired GTP-dependent assembly and mitochondrial fusion activity, which are both improved by cytosolic Bax.

  • Dynamic changes in the regulatory T-cell heterogeneity and function by murine IL-2 mutein
    Open Access
    Dynamic changes in the regulatory T-cell heterogeneity and function by murine IL-2 mutein

    Daniel R Lu, Hao Wu, Ian Driver, Sarah Ingersoll, Sue Sohn, Songli Wang, Chi-Ming Li, Hyewon Phee

    Daniel R Lu ... Hyewon Phee

    Published 8 April 2020

    Single-cell RNA-seq analysis reveals that IL-2 mutein treatment expands multiple sub-states of regulatory T cells with superior suppressive function in mice.

  • Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice
    Open Access
    Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice

    Yaser Salaymeh, Marganit Farago, Shulamit Sebban, Batel Shalom, Eli Pikarsky, Shulamit Katzav

    Yaser Salaymeh ... Shulamit Katzav

    Published 10 April 2020

    Wild-type Vav1 and mutant K-Ras synergistically accelerate pancreatic acinar-to-ductal metaplasia (ADM), thus leading to pancreatic ductal adenocarcinoma (PDAC), depending on Vav1’s activity as a GEF for Rac1.

  • BMAL1 coordinates energy metabolism and differentiation of pluripotent stem cells
    Open Access
    BMAL1 coordinates energy metabolism and differentiation of pluripotent stem cells

    Cristina Ameneiro, Tiago Moreira, Alejandro Fuentes-Iglesias, Alba Coego, Vera Garcia-Outeiral, Adriana Escudero, Daniel Torrecilla, Sonia Mulero-Navarro, Jose Maria Carvajal-Gonzalez, Diana Guallar, Miguel Fidalgo

    Cristina Ameneiro ... Miguel Fidalgo

    Published 13 April 2020

    Although pluripotent cells lack circadian oscillations, this study reveals a novel function of the master circadian regulator BMAL1 in metabolism and early differentiation of embryonic stem cells.

  • The molecular clock protein Bmal1 regulates cell differentiation in mouse embryonic stem cells
    Open Access
    The molecular clock protein Bmal1 regulates cell differentiation in mouse embryonic stem cells

    Amador Gallardo, Aldara Molina, Helena G Asenjo, Jordi Martorell-Marugán, Rosa Montes, Verónica Ramos-Mejia, Antonio Sanchez-Pozo, Pedro Carmona-Sáez, Lourdes Lopez-Onieva, David Landeira

    Amador Gallardo ... David Landeira

    Published 13 April 2020

    Analysis of the role of the molecular clock protein Bmal1 in pluripotent embryonic stem cells reveals a novel function of circadian proteins in cell differentiation and early embryo development.

  • SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration
    Open Access
    SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration

    Ema Ozaki, Luke Gibbons, Nuno GB Neto, Paul Kenna, Michael Carty, Marian Humphries, Pete Humphries, Matthew Campbell, Michael Monaghan, Andrew Bowie, Sarah L Doyle

    Ema Ozaki ... Sarah L Doyle

    Published 20 April 2020

    This study reports that activation of SARM1 causes destruction of NAD pools in photoreceptor cells of the retina and identifies a role for SARM1-dependent photoreceptor cell death in retinal degeneration.

Methods

  • Robust production of uniform human cerebral organoids from pluripotent stem cells
    Open Access
    Robust production of uniform human cerebral organoids from pluripotent stem cells

    Adam A Sivitilli, Jessica T Gosio, Bibaswan Ghoshal, Alesya Evstratova, Daniel Trcka, Parisa Ghiasi, J Javier Hernandez, Jean Martin Beaulieu, Jeffrey L Wrana, Liliana Attisano

    Adam A Sivitilli ... Liliana Attisano

    Published 17 April 2020

    By leveraging advances in 3D stem cell culture techniques, the authors describe, characterize and validate a novel platform to efficiently generate morphologically consistent human forebrain cerebral organoids.

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Volume 3, No. 5
May 2020
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