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Table of Contents

April 2020 | Volume 3, No. 4

Research Articles

  • SLX4IP and telomere dynamics dictate breast cancer metastasis and therapeutic responsiveness
    Open Access
    SLX4IP and telomere dynamics dictate breast cancer metastasis and therapeutic responsiveness

    Nathaniel J Robinson, Chevaun D Morrison-Smith, Alex J Gooding, Barbara J Schiemann, Mark W Jackson, Derek J Taylor, William P Schiemann

    Nathaniel J Robinson ... William P Schiemann

    Published 18 February 2020

    An unbiased genetic screen established SLX4IP as an essential driver of telomere maintenance mechanism identity, metastatic progression, and therapeutic response of breast cancers.

  • Splicing of enhancer-associated lincRNAs contributes to enhancer activity
    Open Access
    Splicing of enhancer-associated lincRNAs contributes to enhancer activity

    Jennifer Y Tan, Adriano Biasini, Robert S Young, Ana C Marques

    Jennifer Y Tan ... Ana C Marques

    Published 21 February 2020

    Analysis of enhancer-associated lincRNA transcripts shows their efficient and conserved splicing contributes to cognate enhancer activity and cis-regulation of target gene expression.

  • Keratinocyte interleukin-36 receptor expression orchestrates psoriasiform inflammation in mice
    Open Access
    Keratinocyte interleukin-36 receptor expression orchestrates psoriasiform inflammation in mice

    Yasmina E Hernández-Santana, Gemma Leon, David St Leger, Padraic G Fallon, Patrick T Walsh

    Yasmina E Hernández-Santana ... Patrick T Walsh

    Published 21 February 2020

    IL-36 stimulation of keratinocytes orchestrates key pathogenic inflammatory responses in psoriatic skin.

  • Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold
    Open Access
    Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold

    Martin P Reichhardt, Vuokko Loimaranta, Susan M Lea, Steven Johnson

    Martin P Reichhardt ... Steven Johnson

    Published 25 February 2020

    The structures of SALSA SRCR domains 1 and 8 reveal a cation-dependent mechanism for ligand recognition, contributing to important roles in the immune system and cellular signalling. The cation-binding sites are conserved across all SRCR domains, suggesting conserved functional mechanisms.

  • BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression
    Open Access
    BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression

    Batya Cohen, Hanoch Tempelhof, Tal Raz, Roni Oren, Julian Nicenboim, Filip Bochner, Ron Even, Adam Jelinski, Raya Eilam, Shifra Ben-Dor, Yoseph Adaddi, Ofra Golani, Shlomi Lazar, Karina Yaniv, Michal Neeman

    Batya Cohen ... Michal Neeman

    Published 4 March 2020

    Our work highlights BACH family of transcription factors as a novel regulator of angiogenesis and lymphangiogenesis during zebrafish embryonic development and tumor expansion.

  • CSDE1 controls gene expression through the miRNA-mediated decay machinery
    Open Access
    CSDE1 controls gene expression through the miRNA-mediated decay machinery

    Pavan Kumar Kakumani, Louis-Mathieu Harvey, François Houle, Tanit Guitart, Fátima Gebauer, Martin J Simard

    Pavan Kumar Kakumani ... Martin J Simard

    Published 11 March 2020

    CSDE1 is a new component of miRNA-induced silencing complex and interacts with DCP1–DCP2 decapping machinery with potential roles in miRNA-mediated target degradation.

  • A novel class of polymorphic toxins in Bacteroidetes
    Open Access
    A novel class of polymorphic toxins in Bacteroidetes

    Biswanath Jana, Dor Salomon, Eran Bosis

    Biswanath Jana ... Eran Bosis

    Published 13 March 2020

    Bacteria often use toxins to mediate their interaction with the environment. This study reveals a new class of polymorphic toxins, which contain an N-terminal TANFOR domain, in Bacteroidetes.

  • <em>Mylk3</em> null C57BL/6N mice develop cardiomyopathy, whereas <em>Nnt</em> null C57BL/6J mice do not
    Open Access
    Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not

    Jack L Williams, Anju Paudyal, Sherine Awad, James Nicholson, Dominika Grzesik, Joaquin Botta, Eirini Meimaridou, Avinaash V Maharaj, Michelle Stewart, Andrew Tinker, Roger D Cox, Lou A Metherell

    Jack L Williams ... Lou A Metherell

    Published 25 March 2020

    Genetic differences between C57BL/6 substrains lead to different cardiovascular traits; a null mutation in Mylk3 likely causes cardiomyopathy in C57BL/6N mice, whereas C57BL/6J Nnt-null mice do not develop cardiomyopathy.

Methods

  • MagnEdit—interacting factors that recruit DNA-editing enzymes to single base targets
    Open Access
    MagnEdit—interacting factors that recruit DNA-editing enzymes to single base targets

    Jennifer L McCann, Daniel J Salamango, Emily K Law, William L Brown, Reuben S Harris

    Jennifer L McCann ... Reuben S Harris

    Published 24 February 2020

    This study reports a new, non-covalent strategy—called MagnEdit—that attracts the DNA cytosine deaminase APOBEC3B to a Cas9-directed site for C-to-T editing.

  • Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function
    Open Access
    Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function

    Konstantinos Koussis, Chrislaine Withers-Martinez, David A Baker, Michael J Blackman

    Konstantinos Koussis ... Michael J Blackman

    Published 16 March 2020

    This work combines the use of an inducible Cre recombinase and different lox sites to simultaneously create multiple allelic replacements. We show that an essential malarial cGMP-dependent protein kinase functions exclusively during the release of the parasite from its host cell.

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Volume 3, No. 4
April 2020
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