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Caspase-1 interdomain linker cleavage is required for pyroptosis

Daniel P Ball, Cornelius Y Taabazuing, Andrew R Griswold, Elizabeth L Orth, Sahana D Rao, Ilana B Kotliar, Lauren E Vostal, Darren C Johnson, View ORCID ProfileDaniel A Bachovchin  Correspondence email
Daniel P Ball
1Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
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Cornelius Y Taabazuing
1Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
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Andrew R Griswold
2Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA
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Elizabeth L Orth
3Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
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Sahana D Rao
3Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
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Ilana B Kotliar
3Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
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Lauren E Vostal
3Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
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Darren C Johnson
3Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
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Daniel A Bachovchin
1Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
3Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
4Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA
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  • ORCID record for Daniel A Bachovchin
  • For correspondence: bachovcd@mskcc.org
Published 12 February 2020. DOI: 10.26508/lsa.202000664
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Caspase-1 activation requires autoproteolysis
Daniel P Ball, Cornelius Y Taabazuing, Andrew R Griswold, Elizabeth L Orth, Sahana D Rao, Ilana B Kotliar, Lauren E Vostal, Darren C Johnson, Daniel A Bachovchin
Life Science Alliance Feb 2020, 3 (3) e202000664; DOI: 10.26508/lsa.202000664

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Caspase-1 activation requires autoproteolysis
Daniel P Ball, Cornelius Y Taabazuing, Andrew R Griswold, Elizabeth L Orth, Sahana D Rao, Ilana B Kotliar, Lauren E Vostal, Darren C Johnson, Daniel A Bachovchin
Life Science Alliance Feb 2020, 3 (3) e202000664; DOI: 10.26508/lsa.202000664
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Volume 3, No. 3
March 2020
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