ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue

Hironori Kato; Kohki Okabe; Masato Miyake; Kazuki Hattori; Tomohiro Fukaya; Kousuke Tanimoto; Shi Beini; Mariko Mizuguchi; Satoru Torii; Satoko Arakawa; Masaya Ono; Yusuke Saito; Takashi Sugiyama; Takashi Funatsu; Katsuaki Sato; Shigeomi Shimizu; Seiichi Oyadomari; Hidenori Ichijo; Hisae Kadowaki; Hideki Nishitoh

doi:10.26508/lsa.201900576

Research Article

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ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue

Hironori Kato, Kohki Okabe, Masato Miyake, View ORCID ProfileKazuki Hattori, Tomohiro Fukaya, Kousuke Tanimoto, Shi Beini, Mariko Mizuguchi, Satoru Torii, Satoko Arakawa, Masaya Ono, Yusuke Saito, Takashi Sugiyama, View ORCID ProfileTakashi Funatsu, Katsuaki Sato, Shigeomi Shimizu, Seiichi Oyadomari, Hidenori Ichijo, Hisae Kadowaki, View ORCID ProfileHideki Nishitoh Correspondence email

Hironori Kato

Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, Miyazaki, Japan

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Kohki Okabe

Laboratory of Bioanalytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

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Masato Miyake

Division of Molecular Biology, Institute for Genome Research, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan

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Kazuki Hattori

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

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ORCID record for Kazuki Hattori

Tomohiro Fukaya

Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan

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Kousuke Tanimoto

Genome Laboratory, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

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Shi Beini

Laboratory of Bioanalytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

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Mariko Mizuguchi

Department of Immunology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan

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Satoru Torii

Department of Pathological Cell Biology, Medical Research Institute, TMDU, Tokyo, Japan

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Satoko Arakawa

Department of Pathological Cell Biology, Medical Research Institute, TMDU, Tokyo, Japan

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Masaya Ono

Department of Clinical Proteomics, National Cancer Center Research Institute, Tokyo, Japan

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Yusuke Saito

Division of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan

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Takashi Sugiyama

Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, Miyazaki, Japan

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Takashi Funatsu

Laboratory of Bioanalytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

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ORCID record for Takashi Funatsu

Katsuaki Sato

Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan

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Shigeomi Shimizu

Department of Pathological Cell Biology, Medical Research Institute, TMDU, Tokyo, Japan

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Seiichi Oyadomari

Division of Molecular Biology, Institute for Genome Research, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan

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Hidenori Ichijo

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

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Hisae Kadowaki

Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, Miyazaki, Japan

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Hideki Nishitoh

Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, Miyazaki, Japan

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ORCID record for Hideki Nishitoh
For correspondence: nishitoh@med.miyazaki-u.ac.jp

Published 6 February 2020. DOI: 10.26508/lsa.201900576

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Role of PERK in mitochondrial function

Hironori Kato, Kohki Okabe, Masato Miyake, Kazuki Hattori, Tomohiro Fukaya, Kousuke Tanimoto, Shi Beini, Mariko Mizuguchi, Satoru Torii, Satoko Arakawa, Masaya Ono, Yusuke Saito, Takashi Sugiyama, Takashi Funatsu, Katsuaki Sato, Shigeomi Shimizu, Seiichi Oyadomari, Hidenori Ichijo, Hisae Kadowaki, Hideki Nishitoh

Life Science Alliance Feb 2020, 3 (3) e201900576; DOI: 10.26508/lsa.201900576