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ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue

Hironori Kato, Kohki Okabe, Masato Miyake, Kazuki Hattori, Tomohiro Fukaya, Kousuke Tanimoto, Shi Beini, Mariko Mizuguchi, Satoru Torii, Satoko Arakawa, Masaya Ono, Yusuke Saito, Takashi Sugiyama, Takashi Funatsu, Katsuaki Sato, Shigeomi Shimizu, Seiichi Oyadomari, Hidenori Ichijo, Hisae Kadowaki, Hideki Nishitoh  Correspondence email
Published 6 February 2020. DOI: 10.26508/lsa.201900576

Article Information

vol. 3 no. 3 e201900576
DOI 
https://doi.org/10.26508/lsa.201900576
PubMed 
32029570
Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received October 9, 2019
  • Revision received January 22, 2020
  • Accepted January 23, 2020
  • Published online February 6, 2020.
Copyright & Usage 
© 2020 Kato et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Hironori Kato1,
  2. Kohki Okabe2,
  3. Masato Miyake3,
  4. Kazuki Hattori4,
  5. Tomohiro Fukaya5,
  6. Kousuke Tanimoto6,
  7. Shi Beini2,
  8. Mariko Mizuguchi7,
  9. Satoru Torii8,
  10. Satoko Arakawa8,
  11. Masaya Ono9,
  12. Yusuke Saito10,
  13. Takashi Sugiyama1,
  14. Takashi Funatsu2,
  15. Katsuaki Sato5,
  16. Shigeomi Shimizu8,
  17. Seiichi Oyadomari3,
  18. Hidenori Ichijo4,
  19. Hisae Kadowaki1 and
  20. Hideki Nishitoh1⇑
  1. 1Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, Miyazaki, Japan
  2. 2Laboratory of Bioanalytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
  3. 3Division of Molecular Biology, Institute for Genome Research, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan
  4. 4Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
  5. 5Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
  6. 6Genome Laboratory, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
  7. 7Department of Immunology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
  8. 8Department of Pathological Cell Biology, Medical Research Institute, TMDU, Tokyo, Japan
  9. 9Department of Clinical Proteomics, National Cancer Center Research Institute, Tokyo, Japan
  10. 10Division of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
  1. Correspondence: nishitoh{at}med.miyazaki-u.ac.jp
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Funding

  • MEXT KAKENHI

    18K06916
    H Kato

  • MEXT KAKENHI

    17H06419
    H Nishitoh

  • MEXT KAKENHI

    18H02973
    H Nishitoh

  • MEXT KAKENHI

    18H04699
    H Nishitoh

  • Project for Creation of Research Platforms and Sharing of Advanced Research Infrastructure and Nanken-Kyoten, TMDU

    H Nishitoh

  • Mitsubishi Foundation

    H Nishitoh

  • MEXT KAKENHI

    JP18H03995
    H Ichijo

  • AMED

    JP19gm5010001
    H Ichijo

  • Uehara Memorial Foundation

    H Nishitoh

  • Astellas Foundation for Research on Metabolic Disorders

    H Nishitoh

  • Takeda Science Foundation

    H Nishitoh
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Role of PERK in mitochondrial function
Hironori Kato, Kohki Okabe, Masato Miyake, Kazuki Hattori, Tomohiro Fukaya, Kousuke Tanimoto, Shi Beini, Mariko Mizuguchi, Satoru Torii, Satoko Arakawa, Masaya Ono, Yusuke Saito, Takashi Sugiyama, Takashi Funatsu, Katsuaki Sato, Shigeomi Shimizu, Seiichi Oyadomari, Hidenori Ichijo, Hisae Kadowaki, Hideki Nishitoh
Life Science Alliance Feb 2020, 3 (3) e201900576; DOI: 10.26508/lsa.201900576
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Volume 3, No. 3
March 2020
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