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Research Article
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Open Access

ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue

Hironori Kato, Kohki Okabe, Masato Miyake, View ORCID ProfileKazuki Hattori, Tomohiro Fukaya, Kousuke Tanimoto, Shi Beini, Mariko Mizuguchi, Satoru Torii, Satoko Arakawa, Masaya Ono, Yusuke Saito, Takashi Sugiyama, View ORCID ProfileTakashi Funatsu, Katsuaki Sato, Shigeomi Shimizu, Seiichi Oyadomari, Hidenori Ichijo, Hisae Kadowaki, View ORCID ProfileHideki Nishitoh  Correspondence email
Hironori Kato
1Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, Miyazaki, Japan
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Kohki Okabe
2Laboratory of Bioanalytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
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Masato Miyake
3Division of Molecular Biology, Institute for Genome Research, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan
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Kazuki Hattori
4Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
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  • ORCID record for Kazuki Hattori
Tomohiro Fukaya
5Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
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Kousuke Tanimoto
6Genome Laboratory, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
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Shi Beini
2Laboratory of Bioanalytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
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Mariko Mizuguchi
7Department of Immunology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
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Satoru Torii
8Department of Pathological Cell Biology, Medical Research Institute, TMDU, Tokyo, Japan
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Satoko Arakawa
8Department of Pathological Cell Biology, Medical Research Institute, TMDU, Tokyo, Japan
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Masaya Ono
9Department of Clinical Proteomics, National Cancer Center Research Institute, Tokyo, Japan
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Yusuke Saito
10Division of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
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Takashi Sugiyama
1Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, Miyazaki, Japan
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Takashi Funatsu
2Laboratory of Bioanalytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
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  • ORCID record for Takashi Funatsu
Katsuaki Sato
5Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
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Shigeomi Shimizu
8Department of Pathological Cell Biology, Medical Research Institute, TMDU, Tokyo, Japan
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Seiichi Oyadomari
3Division of Molecular Biology, Institute for Genome Research, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan
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Hidenori Ichijo
4Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
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Hisae Kadowaki
1Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, Miyazaki, Japan
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Hideki Nishitoh
1Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, Miyazaki, Japan
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  • ORCID record for Hideki Nishitoh
  • For correspondence: nishitoh@med.miyazaki-u.ac.jp
Published 6 February 2020. DOI: 10.26508/lsa.201900576
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Article Information

vol. 3 no. 3 e201900576
DOI 
https://doi.org/10.26508/lsa.201900576
PubMed 
32029570

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received October 9, 2019
  • Revision received January 22, 2020
  • Accepted January 23, 2020
  • Published online February 6, 2020.

Copyright & Usage 
© 2020 Kato et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Hironori Kato1,
  2. Kohki Okabe2,
  3. Masato Miyake3,
  4. Kazuki Hattori4,
  5. Tomohiro Fukaya5,
  6. Kousuke Tanimoto6,
  7. Shi Beini2,
  8. Mariko Mizuguchi7,
  9. Satoru Torii8,
  10. Satoko Arakawa8,
  11. Masaya Ono9,
  12. Yusuke Saito10,
  13. Takashi Sugiyama1,
  14. Takashi Funatsu2,
  15. Katsuaki Sato5,
  16. Shigeomi Shimizu8,
  17. Seiichi Oyadomari3,
  18. Hidenori Ichijo4,
  19. Hisae Kadowaki1 and
  20. Hideki Nishitoh1⇑
  1. 1Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, Miyazaki, Japan
  2. 2Laboratory of Bioanalytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
  3. 3Division of Molecular Biology, Institute for Genome Research, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan
  4. 4Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
  5. 5Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
  6. 6Genome Laboratory, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
  7. 7Department of Immunology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
  8. 8Department of Pathological Cell Biology, Medical Research Institute, TMDU, Tokyo, Japan
  9. 9Department of Clinical Proteomics, National Cancer Center Research Institute, Tokyo, Japan
  10. 10Division of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
  1. Correspondence: nishitoh{at}med.miyazaki-u.ac.jp
View Full Text

Funding

  • MEXT KAKENHI

    18K06916
    H Kato
  • MEXT KAKENHI

    17H06419
    H Nishitoh
  • MEXT KAKENHI

    18H02973
    H Nishitoh
  • MEXT KAKENHI

    18H04699
    H Nishitoh
  • Project for Creation of Research Platforms and Sharing of Advanced Research Infrastructure and Nanken-Kyoten, TMDU

    H Nishitoh
  • Mitsubishi Foundation

    H Nishitoh
  • MEXT KAKENHI

    JP18H03995
    H Ichijo
  • AMED

    JP19gm5010001
    H Ichijo
  • Uehara Memorial Foundation

    H Nishitoh
  • Astellas Foundation for Research on Metabolic Disorders

    H Nishitoh
  • Takeda Science Foundation

    H Nishitoh
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Role of PERK in mitochondrial function
Hironori Kato, Kohki Okabe, Masato Miyake, Kazuki Hattori, Tomohiro Fukaya, Kousuke Tanimoto, Shi Beini, Mariko Mizuguchi, Satoru Torii, Satoko Arakawa, Masaya Ono, Yusuke Saito, Takashi Sugiyama, Takashi Funatsu, Katsuaki Sato, Shigeomi Shimizu, Seiichi Oyadomari, Hidenori Ichijo, Hisae Kadowaki, Hideki Nishitoh
Life Science Alliance Feb 2020, 3 (3) e201900576; DOI: 10.26508/lsa.201900576

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Role of PERK in mitochondrial function
Hironori Kato, Kohki Okabe, Masato Miyake, Kazuki Hattori, Tomohiro Fukaya, Kousuke Tanimoto, Shi Beini, Mariko Mizuguchi, Satoru Torii, Satoko Arakawa, Masaya Ono, Yusuke Saito, Takashi Sugiyama, Takashi Funatsu, Katsuaki Sato, Shigeomi Shimizu, Seiichi Oyadomari, Hidenori Ichijo, Hisae Kadowaki, Hideki Nishitoh
Life Science Alliance Feb 2020, 3 (3) e201900576; DOI: 10.26508/lsa.201900576
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Volume 3, No. 3
March 2020
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