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Research Articles
Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regenerationHigh-fat diet ameliorates muscle dystrophic phenotype by promoting the FAP-dependent myogenesis of satellite cells.
Site-specific phosphorylation regulates the functions of kindlin-3 in a variety of cellsA new monoclonal antibody in combination with mutational analyses shows that a single serine phosphorylation in kindlin-3 is functionally important in both hematopoietic and non-hematopoietic cells.
ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissueThe endoplasmic reticulum-resident sensor PERK is phosphorylated during brown adipocyte differentiation and is required for mitochondrial inner membrane protein biogenesis and thermogenic function.
Gammaherpesvirus-infected germinal center cells express a distinct immunoglobulin repertoireGerminal center B cells infected with gammaherpesvirus display altered repertoire with biased usage of lambda light chain and skewed utilization of IGHV genes.
The health status alters the pituitary function and reproduction of mice in a Cxcr2-dependent mannerThis study explores the effects of microbiota on reproductive function of Cxcr2 knockout animals. Cxcr2 is involved in the control of pituitary action and the subsequent development of mammary gland, uterus and ovary.
The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancerUsing patient-derived organoids the authors show how a specialized polarity pathway protects our gut barrier from stress-induced collapse. Findings highlight both diagnostic and therapeutic potential of the pathway for treating gut barrier dysfunction in aging, cancer, and dysbiosis.
Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2This study reveals a role for the cohesin modifier ESCO2 for maintenance of sister chromatid cohesion in mammalian meiosis and a specific weakness of cohesion within male sex chromosome chromatin
Caspase-1 interdomain linker cleavage is required for pyroptosisThe related human NLRP1 and CARD8 form ASC-dependent and ASC-independent inflammasomes, respectively, both of which require pro-caspase-1 interdomain linker processing for the induction of pyroptosis.
The iron–sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activationThe iron–sulfur cluster helicase DDX11 promotes the generation of ssDNA and the phosphorylation of CHK1 at serine-345, possibly by unwinding replication-dependent DNA secondary structures.
Transglutaminase 2 mediates hypoxia-induced selective mRNA translation via polyamination of 4EBPsThis study highlights the role of transglutaminase 2 in selective mRNA translation of hypoxic cancer cells by polyamination-dependent modulation of 4EBPs, providing a target for cancer treatment.
