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Table of Contents

March 2020 | Volume 3, No. 3

Research Articles

  • Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration
    Open Access
    Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration

    Alessio Reggio, Marco Rosina, Natalie Krahmer, Alessandro Palma, Lucia Lisa Petrilli, Giuliano Maiolatesi, Giorgia Massacci, Illari Salvatori, Cristiana Valle, Stefano Testa, Cesare Gargioli, Claudia Fuoco, Luisa Castagnoli, Gianni Cesareni, Francesca Sacco

    Alessio Reggio ... Francesca Sacco

    Published 4 February 2020

    High-fat diet ameliorates muscle dystrophic phenotype by promoting the FAP-dependent myogenesis of satellite cells.

  • Site-specific phosphorylation regulates the functions of kindlin-3 in a variety of cells
    Open Access
    Site-specific phosphorylation regulates the functions of kindlin-3 in a variety of cells

    Katarzyna Bialkowska, Khalid Sossey-Alaoui, Elzbieta Pluskota, Lahoucine Izem, Jun Qin, Edward F Plow

    Katarzyna Bialkowska ... Edward F Plow

    Published 5 February 2020

    A new monoclonal antibody in combination with mutational analyses shows that a single serine phosphorylation in kindlin-3 is functionally important in both hematopoietic and non-hematopoietic cells.

  • ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue
    Open Access
    ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue

    Hironori Kato, Kohki Okabe, Masato Miyake, Kazuki Hattori, Tomohiro Fukaya, Kousuke Tanimoto, Shi Beini, Mariko Mizuguchi, Satoru Torii, Satoko Arakawa, Masaya Ono, Yusuke Saito, Takashi Sugiyama, Takashi Funatsu, Katsuaki Sato, Shigeomi Shimizu, Seiichi Oyadomari, Hidenori Ichijo, Hisae Kadowaki, Hideki Nishitoh

    Hironori Kato ... Hideki Nishitoh

    Published 6 February 2020

    The endoplasmic reticulum-resident sensor PERK is phosphorylated during brown adipocyte differentiation and is required for mitochondrial inner membrane protein biogenesis and thermogenic function.

  • Gammaherpesvirus-infected germinal center cells express a distinct immunoglobulin repertoire
    Open Access
    Gammaherpesvirus-infected germinal center cells express a distinct immunoglobulin repertoire

    Monika A Zelazowska, Qiwen Dong, Joshua B Plummer, Yi Zhong, Bin Liu, Laurie T Krug, Kevin M McBride

    Monika A Zelazowska ... Kevin M McBride

    Published 6 February 2020

    Germinal center B cells infected with gammaherpesvirus display altered repertoire with biased usage of lambda light chain and skewed utilization of IGHV genes.

  • The health status alters the pituitary function and reproduction of mice in a <em>Cxcr2</em>-dependent manner
    Open Access
    The health status alters the pituitary function and reproduction of mice in a Cxcr2-dependent manner

    Colin Timaxian, Isabelle Raymond-Letron, Céline Bouclier, Linda Gulliver, Ludovic Le Corre, Karim Chébli, Anne Guillou, Patrice Mollard, Karl Balabanian, Gwendal Lazennec

    Colin Timaxian ... Gwendal Lazennec

    Published 10 February 2020

    This study explores the effects of microbiota on reproductive function of Cxcr2 knockout animals. Cxcr2 is involved in the control of pituitary action and the subsequent development of mammary gland, uterus and ovary.

  • The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer
    Open Access
    The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer

    Pradipta Ghosh, Lee Swanson, Ibrahim M Sayed, Yash Mittal, Blaze B Lim, Stella-Rita Ibeawuchi, Marc Foretz, Benoit Viollet, Debashis Sahoo, Soumita Das

    Pradipta Ghosh ... Soumita Das

    Published 10 February 2020

    Using patient-derived organoids the authors show how a specialized polarity pathway protects our gut barrier from stress-induced collapse. Findings highlight both diagnostic and therapeutic potential of the pathway for treating gut barrier dysfunction in aging, cancer, and dysbiosis.

  • Meiotic sex chromosome cohesion and autosomal synapsis are supported by <em>Esco2</em>
    Open Access
    Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2

    François McNicoll, Anne Kühnel, Uddipta Biswas, Kai Hempel, Gabriela Whelan, Gregor Eichele, Rolf Jessberger

    François McNicoll ... Rolf Jessberger

    Published 12 February 2020

    This study reveals a role for the cohesin modifier ESCO2 for maintenance of sister chromatid cohesion in mammalian meiosis and a specific weakness of cohesion within male sex chromosome chromatin

  • Caspase-1 interdomain linker cleavage is required for pyroptosis
    Open Access
    Caspase-1 interdomain linker cleavage is required for pyroptosis

    Daniel P Ball, Cornelius Y Taabazuing, Andrew R Griswold, Elizabeth L Orth, Sahana D Rao, Ilana B Kotliar, Lauren E Vostal, Darren C Johnson, Daniel A Bachovchin

    Daniel P Ball ... Daniel A Bachovchin

    Published 12 February 2020

    The related human NLRP1 and CARD8 form ASC-dependent and ASC-independent inflammasomes, respectively, both of which require pro-caspase-1 interdomain linker processing for the induction of pyroptosis.

  • The iron–sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation
    Open Access
    The iron–sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation

    Anna K Simon, Sandra Kummer, Sebastian Wild, Aleksandra Lezaja, Federico Teloni, Stanislaw K Jozwiakowski, Matthias Altmeyer, Kerstin Gari

    Anna K Simon ... Kerstin Gari

    Published 18 February 2020

    The iron–sulfur cluster helicase DDX11 promotes the generation of ssDNA and the phosphorylation of CHK1 at serine-345, possibly by unwinding replication-dependent DNA secondary structures.

  • Transglutaminase 2 mediates hypoxia-induced selective mRNA translation via polyamination of 4EBPs
    Open Access
    Transglutaminase 2 mediates hypoxia-induced selective mRNA translation via polyamination of 4EBPs

    Sung-Yup Cho, Seungun Lee, Jeonghun Yeom, Hyo-Jun Kim, Jin-Haeng Lee, Ji-Woong Shin, Mee-ae Kwon, Ki Baek Lee, Eui Man Jeong, Hee Sung Ahn, Dong-Myung Shin, Kyunggon Kim, In-Gyu Kim

    Sung-Yup Cho ... In-Gyu Kim

    Published 19 February 2020

    This study highlights the role of transglutaminase 2 in selective mRNA translation of hypoxic cancer cells by polyamination-dependent modulation of 4EBPs, providing a target for cancer treatment.

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Volume 3, No. 3
March 2020
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